TPR and NUP153

Number of citations of the paper that reports this interaction (PubMedID 37071682)
87

Data Source:
BioGRID (affinity chromatography technology, fluorescent resonance energy transfer, biochemical, cross-linking study)
HPRD (in vitro, in vivo, two hybrid)

		TPR	NUP153
Description		translocated promoter region, nuclear basket protein	nucleoporin 153
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Chromosome Cytoplasm Spindle Cytoskeleton Cytoplasmic Dynein Complex Membrane Nuclear Membrane Nuclear Periphery Nuclear Inclusion Body Nuclear Pore Nuclear Basket Mitotic Spindle	Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Nucleolus Cytosol Membrane Nuclear Membrane Nuclear Periphery Nuclear Inclusion Body Host Cell Nuclear Pore Nuclear Basket
	Molecular Function	Chromatin Binding RNA Binding MRNA Binding Protein Binding Tubulin Binding Structural Constituent Of Nuclear Pore Heat Shock Protein Binding Protein Homodimerization Activity Protein-membrane Adaptor Activity Mitogen-activated Protein Kinase Binding Dynein Complex Binding	DNA Binding Protein Binding Nuclear Localization Sequence Binding Zinc Ion Binding Structural Constituent Of Nuclear Pore Identical Protein Binding Protein-membrane Adaptor Activity Metal Ion Binding Molecular Condensate Scaffold Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II RNA Import Into Nucleus RNA Export From Nucleus MRNA Export From Nucleus Protein Import Into Nucleus Protein Export From Nucleus Intracellular Protein Transport Nucleocytoplasmic Transport Nuclear Pore Organization Mitotic Spindle Assembly Checkpoint Signaling Regulation Of MRNA Export From Nucleus Regulation Of Mitotic Sister Chromatid Separation Protein Transport Positive Regulation Of Heterochromatin Formation Regulation Of Protein Stability MRNA Export From Nucleus In Response To Heat Stress Regulation Of Protein Localization Cellular Response To Heat Cellular Response To Interferon-alpha Regulation Of Protein Import Into Nucleus Positive Regulation Of Protein Import Into Nucleus Nuclear Matrix Organization Negative Regulation Of Translational Initiation Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Export From Nucleus Negative Regulation Of RNA Export From Nucleus MRNA Transport Nuclear Export Nuclear Pore Complex Assembly Cell Division Response To Epidermal Growth Factor Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Intracellular Protein Transport Regulation Of Mitotic Spindle Assembly	RNA Export From Nucleus Protein Import Into Nucleus Nucleocytoplasmic Transport Protein Transport Symbiont Entry Into Host Cell Negative Regulation Of RNA Export From Nucleus MRNA Transport Nuclear Pore Complex Assembly Viral Penetration Into Host Nucleus Amyloid Fibril Formation
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events SARS-CoV-2 activates/modulates innate and adaptive immune responses Signaling by ALK fusions and activated point mutants	ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases		Thyroid cancer
GWAS			Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 18391951) Obesity-related traits ( 23251661)
Interacting Genes		20 interacting genes: APC CDK1 ERCC6 HTT IFI16 MAD1L1 MAP3K4 MAPK1 MDM2 MECOM NUP153 NUP98 PRKACA SHC1 SUMO2 TNFSF4 USP7 WEE2-AS1 YWHAQ ZC3HC1	31 interacting genes: APC BRCA1 CEBPA CLK1 DNMT3A DTNBP1 DYNLT1 FILNC1 GRSF1 IPO5 KPNA2 KPNB1 MAPK1 MAPK14 MAPK3 MRPS5 NUP62 NXF1 NXF2 PTGER4 RAN SENP2 SMAD2 SMAD3 TNPO1 TPR TRN-GTT2-7 XPO1 XPO5 XPO7 XPOT
Entrez ID		7175	9972
HPRD ID		08927	04899
Ensembl ID		ENSG00000047410	ENSG00000124789
Uniprot IDs		P12270	P49790
PDB IDs		5TO5 5TO6 5TO7 5TVB	2EBQ 2EBR 2EBV 2GQE 4U0C 4U0D 5TSV 5TSX 6AYA 8CKY 8CL0 9CNU
Enriched GO Terms of Interacting Partners?		Nuclear Pore Nuclear Basket Intracellular Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Chromosome Organization Regulation Of Intracellular Transport Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Chromosome Organization Nucleoplasm Regulation Of Nucleocytoplasmic Transport Cellular Response To Nutrient Levels Regulation Of DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Regulation Of Primary Metabolic Process DNA Damage Response Regulation Of Cellular Localization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Mitotic Sister Chromatid Segregation Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Protein Catabolic Process Positive Regulation Of Biosynthetic Process RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Nuclear Pore Complex Assembly Protein Localization To Organelle Negative Regulation Of Metabolic Process Transcription-coupled Nucleotide-excision Repair P53 Binding Regulation Of Proteasomal Protein Catabolic Process Nuclear Inclusion Body Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Nuclear Envelope Insulin Receptor Signaling Pathway Nucleus Regulation Of Macromolecule Biosynthetic Process Regulation Of Metaphase Plate Congression Response To UV-C Nuclear Pore Organization Negative Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Protein Metabolic Process Regulation Of Cell Cycle MAPK Cascade Nucleus Organization Positive Regulation Of Intracellular Protein Transport	Nuclear Transport Nucleocytoplasmic Transport Nuclear Pore RNA Transport Nuclear Export RNA Export From Nucleus Nucleobase-containing Compound Transport Protein Transport Establishment Of Protein Localization Regulation Of Intracellular Transport Protein Localization To Nucleus Intracellular Protein Transport Protein Import Into Nucleus Nucleoplasm Import Into Nucleus Protein Export From Nucleus Intracellular Transport Nuclear Export Signal Receptor Activity Positive Regulation Of Protein Import Into Nucleus Intracellular Protein Localization Establishment Of Localization In Cell RNA Import Into Nucleus Nuclear Import Signal Receptor Activity Regulation Of Nucleocytoplasmic Transport Nuclear Localization Sequence Binding Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Nuclear Envelope MRNA Transport RNA Binding Cellular Localization Positive Regulation Of Intracellular Transport Regulation Of Intracellular Protein Transport Regulation Of Cellular Localization Nuclear Membrane Positive Regulation Of Intracellular Protein Transport Small GTPase Binding Cellular Response To Tumor Necrosis Factor Positive Regulation Of Protein Localization To Nucleus Nucleus Establishment Of Protein Localization To Organelle Phosphatase Binding Response To Tumor Necrosis Factor Regulation Of Ossification MAP Kinase Activity RNA Nuclear Export Complex Pre-miRNA Export From Nucleus Regulation Of Cytoskeleton Organization MRNA Export From Nucleus Cytoplasm
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