NUP153 and XPO5

Number of citations of the paper that reports this interaction (PubMedID 11777942)
42

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		NUP153	XPO5
Description		nucleoporin 153	exportin 5
Image
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Nucleolus Cytosol Membrane Nuclear Membrane Nuclear Periphery Nuclear Inclusion Body Host Cell Nuclear Pore Nuclear Basket	Nucleus Nucleoplasm Cytoplasm Cytosol RISC Complex RNA Nuclear Export Complex
	Molecular Function	DNA Binding Protein Binding Nuclear Localization Sequence Binding Zinc Ion Binding Structural Constituent Of Nuclear Pore Identical Protein Binding Protein-membrane Adaptor Activity Metal Ion Binding Molecular Condensate Scaffold Activity	TRNA Binding RNA Binding MRNA Binding Nuclear Export Signal Receptor Activity Protein Binding Small GTPase Binding Pre-miRNA Binding RISC Complex Binding
	Biological Process	RNA Export From Nucleus Protein Import Into Nucleus Nucleocytoplasmic Transport Protein Transport Symbiont Entry Into Host Cell Negative Regulation Of RNA Export From Nucleus MRNA Transport Nuclear Pore Complex Assembly Viral Penetration Into Host Nucleus Amyloid Fibril Formation	RNA Export From Nucleus Protein Export From Nucleus Intracellular Protein Transport MiRNA Metabolic Process Protein Transport Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Export From Nucleus
Pathways		ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events SARS-CoV-2 activates/modulates innate and adaptive immune responses	MicroRNA (miRNA) biogenesis
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 18391951) Obesity-related traits ( 23251661)	Hemoglobin levels ( 32327693) Platelet count ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		31 interacting genes: APC BRCA1 CEBPA CLK1 DNMT3A DTNBP1 DYNLT1 FILNC1 GRSF1 IPO5 KPNA2 KPNB1 MAPK1 MAPK14 MAPK3 MRPS5 NUP62 NXF1 NXF2 PTGER4 RAN SENP2 SMAD2 SMAD3 TNPO1 TPR TRN-GTT2-7 XPO1 XPO5 XPO7 XPOT	10 interacting genes: CEBPA EEF1A1 FADD ILF3 NUP153 NUP214 RAN SMAD4 SUMO2 ZNF346
Entrez ID		9972	57510
HPRD ID		04899	06385
Ensembl ID		ENSG00000124789	ENSG00000124571
Uniprot IDs		P49790	Q9HAV4
PDB IDs		2EBQ 2EBR 2EBV 2GQE 4U0C 4U0D 5TSV 5TSX 6AYA 8CKY 8CL0 9CNU	3A6P 5YU6 5YU7
Enriched GO Terms of Interacting Partners?		Nuclear Transport Nucleocytoplasmic Transport Nuclear Pore RNA Transport Nuclear Export RNA Export From Nucleus Nucleobase-containing Compound Transport Protein Transport Establishment Of Protein Localization Regulation Of Intracellular Transport Protein Localization To Nucleus Intracellular Protein Transport Protein Import Into Nucleus Nucleoplasm Import Into Nucleus Protein Export From Nucleus Intracellular Transport Nuclear Export Signal Receptor Activity Positive Regulation Of Protein Import Into Nucleus Intracellular Protein Localization Establishment Of Localization In Cell RNA Import Into Nucleus Nuclear Import Signal Receptor Activity Regulation Of Nucleocytoplasmic Transport Nuclear Localization Sequence Binding Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Nuclear Envelope MRNA Transport RNA Binding Cellular Localization Positive Regulation Of Intracellular Transport Regulation Of Intracellular Protein Transport Regulation Of Cellular Localization Nuclear Membrane Positive Regulation Of Intracellular Protein Transport Small GTPase Binding Cellular Response To Tumor Necrosis Factor Positive Regulation Of Protein Localization To Nucleus Nucleus Establishment Of Protein Localization To Organelle Phosphatase Binding Response To Tumor Necrosis Factor Regulation Of Ossification MAP Kinase Activity RNA Nuclear Export Complex Pre-miRNA Export From Nucleus Regulation Of Cytoskeleton Organization MRNA Export From Nucleus Cytoplasm	Nucleolus Protein-containing Complex Binding Regulation Of Protein Catabolic Process Interleukin-6-mediated Signaling Pathway RNA Export From Nucleus Nuclear Export Signal Receptor Activity Nuclear Export Regulation Of Nucleocytoplasmic Transport Import Into Nucleus Protein Import Into Nucleus Nuclear Pore Regulation Of Protein Metabolic Process RNA Transport Structural Constituent Of Nuclear Pore Nuclear Localization Sequence Binding Protein Localization To Nucleus Protein Export From Nucleus Positive Regulation Of Proteolysis Nucleobase-containing Compound Transport Nucleoplasm Nuclear Envelope Nuclear Transport Nucleocytoplasmic Transport Regulation Of Intracellular Transport Gland Development RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Cytoplasmic Side Of Nuclear Pore Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Protein-containing Complex Double-stranded RNA Binding Establishment Of Protein Localization To Organelle Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nucleus Regulation Of Proteolysis Response To Vitamin B2 C/EBP Complex RNA Binding Gonad Morphogenesis Nephrogenic Mesenchyme Morphogenesis RNA Nuclear Export Complex SnRNA Import Into Nucleus Pre-miRNA Export From Nucleus Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation Death-inducing Signaling Complex Assembly Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription
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