TNNT2 and TPM1

Number of citations of the paper that reports this interaction (PubMedID 6746613)
0

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		TNNT2	TPM1
Description		troponin T2, cardiac type	tropomyosin 1
Image
GO Annotations	Cellular Component	Cytosol Troponin Complex Striated Muscle Thin Filament Sarcomere Cardiac Myofibril Cardiac Troponin Complex	Stress Fiber Cytoplasm Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Actin Filament Actin Cytoskeleton Sarcomere Bleb Ruffle Membrane
	Molecular Function	Microfilament Motor Activity Actin Binding Protein Binding Tropomyosin Binding Troponin C Binding Troponin I Binding Identical Protein Binding	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Actin Filament Binding
	Biological Process	Regulation Of Muscle Contraction Striated Muscle Contraction Regulation Of Heart Contraction Muscle Filament Sliding Negative Regulation Of ATP-dependent Activity Positive Regulation Of ATP-dependent Activity Sarcomere Organization Response To Calcium Ion Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction	Positive Regulation Of Heart Rate By Epinephrine Regulation Of Muscle Contraction Cytoskeleton Organization Actin Filament Organization Regulation Of Heart Contraction Regulation Of Cell Shape Muscle Filament Sliding Negative Regulation Of Cell Migration Ruffle Organization Cellular Response To Reactive Oxygen Species Wound Healing Sarcomere Organization Positive Regulation Of Cell Adhesion Positive Regulation Of Stress Fiber Assembly Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways		Striated Muscle Contraction	Striated Muscle Contraction Smooth Muscle Contraction
Drugs			Artenimol Phenethyl Isothiocyanate
Diseases		Dilated cardiomyopathy (DCM) Hypertrophic cardiomyopathy (HCM)	Dilated cardiomyopathy (DCM) Hypertrophic cardiomyopathy (HCM)
GWAS		Cardiac Troponin-T levels ( 23247143) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 28552196) Neurofibrillary tangles ( 25188341)	Apolipoprotein A1 levels ( 32203549) Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31451708) HDL cholesterol levels ( 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hemoglobin ( 32888494) Impaired insulin sensitivity in response to n-3 PUFA supplementation ( 31779001) Mean platelet volume ( 27863252 32888494 19820697) Orofacial clefts ( 22863734) Parkinson's disease ( 32201043) Parkinson's disease (familial, age at onset) ( 27402877) Platelet count ( 32888494 22139419 27863252) Platelet distribution width ( 27863252 32888494) Pulse pressure ( 27841878) Refractive error ( 32231278) Reticulocyte fraction of red cells ( 32888494) Triglyceride levels ( 32203549)
Interacting Genes		16 interacting genes: APP KDM1A MAP3K5 MLX MORF4L1 MORF4L2 MST1 NOTCH3 PPP2R5A PRKCA TNNC1 TNNI1 TNNI3 TNNT1 TPM1 TRIM69	31 interacting genes: ACTB BLOC1S6 C1orf216 CAGE1 CCHCR1 CDC42 CLIP4 EGFR EPB41 FGA GOLGA2 H19 IFIT3 JUN KXD1 LINC00632 MAD1L1 MAST2 NEB NOD2 PKD2 PSMC5 S100A2 SNAPIN TFPT TMOD2 TNNT1 TNNT2 TPM2 WASHC1 YEATS4
Entrez ID		7139	7168
HPRD ID		01844	01839
Ensembl ID		ENSG00000118194	ENSG00000140416
Uniprot IDs		A0AAQ5BHX3 P45379 Q15607	A0A0K0K1I0 A0A0S2Z4G6 A0A494BZZ2 B7Z596 B7Z722 D9YZV4 D9YZV5 D9YZV7 F5H7S3 H0YK48 H0YKJ4 H7BYY1 O15513 P09493 Q6ZN40
PDB IDs		1J1D 1J1E 4Y99 6KN7 6KN8 7UTI 7UTL 8FMM 8FMN 8FMO 8FMP 8FMQ 8FMR 8FMS 8FMT	3MUD 5KHT 6UT2 6X5Z 7UTI 7UTL 8EFH 8EFI 8ENC 8ZB7
Enriched GO Terms of Interacting Partners?		Troponin Complex Troponin T Binding Striated Muscle Contraction Skeletal Muscle Contraction Transition Between Fast And Slow Fiber Regulation Of Muscle System Process Cardiac Muscle Contraction Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Skeletal Muscle Adaptation Cardiac Muscle Tissue Morphogenesis Regulation Of System Process Muscle Filament Sliding Regulation Of Muscle Contraction Actin-myosin Filament Sliding Muscle Tissue Morphogenesis Muscle Contraction Cardiac Troponin Complex Muscle System Process Actin-mediated Cell Contraction Regulation Of Smooth Muscle Cell Proliferation Sarcomere Actin Filament-based Movement Regulation Of Double-strand Break Repair Via Homologous Recombination Contractile Muscle Fiber Positive Regulation Of Smooth Muscle Cell Proliferation Anatomical Structure Morphogenesis System Process Regulation Of DNA Recombination NuA4 Histone Acetyltransferase Complex Regulation Of Double-strand Break Repair Protein Homodimerization Activity Neuron Maturation Positive Regulation Of RNA Biosynthetic Process Enzyme Binding Cytosol Positive Regulation Of DNA-templated Transcription Response To Reactive Oxygen Species Tissue Morphogenesis Actin Filament-based Process Sarcomere Organization Amyloid-beta Complex Growth Cone Lamellipodium Chromatin Organization Regulation Of Response To Calcium Ion Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Amylin Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Toll Signaling Pathway Regulation Of Muscle Filament Sliding Speed Actin Filament Binding	Cytoskeleton Organization Identical Protein Binding Mitotic Spindle Actin Filament Organization Actin Binding Tropomyosin Binding BLOC-1 Complex Organelle Transport Along Microtubule Supramolecular Fiber Organization Cytoskeleton Actin Cytoskeleton Organization Actomyosin Structure Organization Organelle Organization Actin Filament-based Process Troponin Complex Regulation Of Lysosome Size BORC Complex Positive Regulation Of DNA Repair Response To Calcium Ion Striated Muscle Thin Filament Microvesicle Regulation Of Endosome Size General Transcription Initiation Factor Binding Positive Regulation Of Pseudopodium Assembly Cytoplasmic Side Of Lysosomal Membrane Transport Along Microtubule Eyelid Development In Camera-type Eye Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Cycle Positive Regulation Of Epithelial Cell Proliferation Cytoskeleton-dependent Intracellular Transport Actin Filament Binding Muscle Contraction Anterograde Synaptic Vesicle Transport Regulation Of Vesicle Size Microtubule-based Transport Structural Constituent Of Cytoskeleton Regulation Of DNA Repair System Process Regulation Of Programmed Cell Death Embryonic Placenta Development Basolateral Plasma Membrane Host-mediated Perturbation Of Symbiont Process NuA4 Histone Acetyltransferase Complex Regulation Of Cellular Component Size Muscle System Process Cortical Cytoskeleton Blood Microparticle Positive Regulation Of DNA Metabolic Process Positive Regulation Of Norepinephrine Uptake
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