TPM1 and NEB

Number of citations of the paper that reports this interaction (PubMedID 25110572)
45

Data Source:
BioGRID (pull down)

		TPM1	NEB
Description		tropomyosin 1	nebulin
Image
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Actin Filament Actin Cytoskeleton Sarcomere Bleb Ruffle Membrane	Cytoplasm Cytosol Cytoskeleton Actin Cytoskeleton Myofibril Sarcomere Z Disc Contractile Muscle Fiber Extracellular Exosome
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Actin Filament Binding	Actin Binding Protein Binding Structural Constituent Of Muscle Actin Filament Binding
	Biological Process	Positive Regulation Of Heart Rate By Epinephrine Regulation Of Muscle Contraction Cytoskeleton Organization Actin Filament Organization Regulation Of Heart Contraction Regulation Of Cell Shape Muscle Filament Sliding Negative Regulation Of Cell Migration Ruffle Organization Cellular Response To Reactive Oxygen Species Wound Healing Sarcomere Organization Positive Regulation Of Cell Adhesion Positive Regulation Of Stress Fiber Assembly Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration	Muscle Organ Development Somatic Muscle Development Regulation Of Actin Filament Length Cardiac Muscle Thin Filament Assembly
Pathways		Striated Muscle Contraction Smooth Muscle Contraction	Striated Muscle Contraction
Drugs		Artenimol Phenethyl Isothiocyanate
Diseases		Dilated cardiomyopathy (DCM) Hypertrophic cardiomyopathy (HCM)	Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Nemaline myopathy
GWAS		Apolipoprotein A1 levels ( 32203549) Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31451708) HDL cholesterol levels ( 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hemoglobin ( 32888494) Impaired insulin sensitivity in response to n-3 PUFA supplementation ( 31779001) Mean platelet volume ( 27863252 32888494 19820697) Orofacial clefts ( 22863734) Parkinson's disease ( 32201043) Parkinson's disease (familial, age at onset) ( 27402877) Platelet count ( 32888494 22139419 27863252) Platelet distribution width ( 27863252 32888494) Pulse pressure ( 27841878) Refractive error ( 32231278) Reticulocyte fraction of red cells ( 32888494) Triglyceride levels ( 32203549)	Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time) ( 27114598) Creatine kinase levels ( 29403010) Estimated glomerular filtration rate ( 31152163 31451708) Letter-number span reordering ( 31596458) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Rapid automised naming of letters ( 30741946) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097) Skeletal muscle index ( 33674626) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		31 interacting genes: ACTB BLOC1S6 C1orf216 CAGE1 CCHCR1 CDC42 CLIP4 EGFR EPB41 FGA GOLGA2 H19 IFIT3 JUN KXD1 LINC00632 MAD1L1 MAST2 NEB NOD2 PKD2 PSMC5 S100A2 SNAPIN TFPT TMOD2 TNNT1 TNNT2 TPM2 WASHC1 YEATS4	25 interacting genes: ABI1 ACO1 ACTG2 ACTN4 AKTIP APC CALM1 DES ENO3 LIMS1 MTDH MYOM2 MYPN PTPN11 STRADB TMOD1 TMOD4 TPM1 TPM2 TRIM55 TRIM63 TTN USP7 XIRP1 XIRP2
Entrez ID		7168	4703
HPRD ID		01839	01196
Ensembl ID		ENSG00000140416	ENSG00000183091
Uniprot IDs		A0A0K0K1I0 A0A0S2Z4G6 A0A494BZZ2 B7Z596 B7Z722 D9YZV4 D9YZV5 D9YZV7 F5H7S3 H0YK48 H0YKJ4 H7BYY1 O15513 P09493 Q6ZN40	P20929 Q05C45 Q96MF8
PDB IDs		3MUD 5KHT 6UT2 6X5Z 7UTI 7UTL 8EFH 8EFI 8ENC 8ZB7	1ARK 1NEB 6Y17
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organization Identical Protein Binding Mitotic Spindle Actin Filament Organization Actin Binding Tropomyosin Binding BLOC-1 Complex Organelle Transport Along Microtubule Supramolecular Fiber Organization Cytoskeleton Actin Cytoskeleton Organization Actomyosin Structure Organization Organelle Organization Actin Filament-based Process Troponin Complex Regulation Of Lysosome Size BORC Complex Positive Regulation Of DNA Repair Response To Calcium Ion Striated Muscle Thin Filament Microvesicle Regulation Of Endosome Size General Transcription Initiation Factor Binding Positive Regulation Of Pseudopodium Assembly Cytoplasmic Side Of Lysosomal Membrane Transport Along Microtubule Eyelid Development In Camera-type Eye Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell Cycle Positive Regulation Of Epithelial Cell Proliferation Cytoskeleton-dependent Intracellular Transport Actin Filament Binding Muscle Contraction Anterograde Synaptic Vesicle Transport Regulation Of Vesicle Size Microtubule-based Transport Structural Constituent Of Cytoskeleton Regulation Of DNA Repair System Process Regulation Of Programmed Cell Death Embryonic Placenta Development Basolateral Plasma Membrane Host-mediated Perturbation Of Symbiont Process NuA4 Histone Acetyltransferase Complex Regulation Of Cellular Component Size Muscle System Process Cortical Cytoskeleton Blood Microparticle Positive Regulation Of DNA Metabolic Process Positive Regulation Of Norepinephrine Uptake	Muscle Contraction Actin Binding Actin Cytoskeleton Organization Muscle System Process Actin Filament Organization Actin Filament-based Process Actomyosin Structure Organization Supramolecular Fiber Organization Z Disc Cytoskeletal Protein Binding Cytoplasm Striated Muscle Thin Filament Actin Filament Binding Sarcomere Organization Structural Constituent Of Muscle Cytoskeleton Organization Sarcomere M Band Stress Fiber Myofibril Assembly Muscle Thin Filament Tropomyosin System Process Cytoskeleton Anchoring Junction Pointed-end Actin Filament Capping Actin Cytoskeleton Cardiac Muscle Tissue Morphogenesis Organelle Organization Actin Filament-based Movement Titin Binding Contractile Muscle Fiber Tropomyosin Binding Muscle Tissue Morphogenesis Cell Junction Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Supramolecular Fiber Organization Muscle Filament Sliding Muscle Alpha-actinin Binding Protein Kinase Regulator Activity Actin Filament Actin-myosin Filament Sliding Regulation Of Protein Depolymerization Skeletal Muscle Organ Development Protein Kinase Binding Myosin Filament Megakaryocyte Development Regulation Of Actin Filament Organization I Band Cytosol Regulation Of Protein-containing Complex Disassembly
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