TNNT1 and OSBP2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		TNNT1	OSBP2
Description		troponin T1, slow skeletal type	oxysterol binding protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Troponin Complex	Acrosomal Vesicle Cytosol Plasma Membrane Membrane Cytoplasmic Vesicle Perinuclear Endoplasmic Reticulum Apical Dendrite
	Molecular Function	Protein Binding Tropomyosin Binding Troponin T Binding	Protein Binding Lipid Binding Cholesterol Binding Sterol Binding
	Biological Process	Skeletal Muscle Contraction Regulation Of Muscle Contraction Transition Between Fast And Slow Fiber Slow-twitch Skeletal Muscle Fiber Contraction Sarcomere Organization Negative Regulation Of Muscle Contraction	Lipid Transport Spermatogenesis Spermatid Development Cell Differentiation
Pathways		Striated Muscle Contraction
Drugs
Diseases		Nemaline myopathy
GWAS		Height ( 31562340)	Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) ( 23648065) Estimated glomerular filtration rate change in renal transplantation (donor effect) ( 30920136) Red cell distribution width ( 32888494) Refractive error ( 32231278) Response to ketamine in bipolar disorder or major depression (antidepressant effects) ( 30552317) Takayasu arteritis ( 33308445)
Interacting Genes		69 interacting genes: ARMC8 BLOC1S2 BMPR1B CCDC136 CCDC85B CHD3 CLIP4 DDX5 EEF1G FAF1 FXR2 FYN HAP1 HMGXB4 HSP90AB1 IMMT KAT5 KRT27 KRT40 LARP1 LDOC1 MARS1 MORF4L1 MYOM2 NACAD NAGK NFE2L2 NINL NSG2 OSBP2 OSM PI4KA PLEKHF1 PNMA1 PPFIA1 PRKG1 PSMC5 SBK3 SDCBP2 SEC31A SERPINA4 SH3GL3 SMAD1 SMAD2 SMURF1 SNW1 TBPL1 TFIP11 TGFBR1 TMEM98 TNNC1 TNNI1 TNNI2 TNNI3 TNNT2 TPM1 TPM3 TRA2A TRIM63 TSPYL2 TULP3 UBE2D1 VIM WDCP ZC3H15 ZKSCAN5 ZMYND19 ZNF250 ZNF768	6 interacting genes: DLG3 GOPC LNX1 PICK1 TNNT1 VIM
Entrez ID		7138	23762
HPRD ID		01841	09471
Ensembl ID		ENSG00000105048	ENSG00000184792
Uniprot IDs		P13805	Q969R2
PDB IDs
Enriched GO Terms of Interacting Partners?		Troponin Complex Cardiac Muscle Contraction Ventricular Cardiac Muscle Tissue Morphogenesis SMAD Binding Muscle System Process Cardiac Troponin Complex Cardiac Muscle Tissue Morphogenesis Muscle Contraction Troponin T Binding Muscle Filament Sliding I-SMAD Binding Muscle Tissue Morphogenesis Actin-myosin Filament Sliding Striated Muscle Contraction Protein Binding Skeletal Muscle Contraction Primary MiRNA Processing Homomeric SMAD Protein Complex Actin-mediated Cell Contraction Contractile Muscle Fiber Regulation Of Hematopoietic Stem Cell Differentiation Tissue Morphogenesis Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Troponin C Binding Regulation Of Muscle System Process Regulation Of Muscle Contraction Sarcomere Response To Muramyl Dipeptide Regulation Of Primary Metabolic Process Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Troponin I Binding Muscle Thin Filament Tropomyosin Cytosol Actin Filament-based Movement Regulation Of Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Cytoskeleton Organization Transforming Growth Factor Beta Receptor Activity, Type I Disordered Domain Specific Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process R-SMAD Binding Cytoplasm Negative Regulation Of Smooth Muscle Cell Migration Regulation Of Stem Cell Differentiation Calcium-dependent Protein Binding SMAD Protein Complex Trophoblast Cell Migration Transition Between Fast And Slow Fiber Cardiac Myofibril	Neuron Projection Receptor Clustering Slow-twitch Skeletal Muscle Fiber Contraction Glial Cell Development Negative Regulation Of Anion Channel Activity Localization Within Membrane Troponin T Binding Identical Protein Binding Membrane Curvature Sensor Activity Keratin Filament Binding Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Troponin Complex Transition Between Fast And Slow Fiber Lens Fiber Cell Development Protein Domain Specific Binding Negative Regulation Of Actin Nucleation Regulation Of Skeletal Muscle Adaptation Cellular Response To Muramyl Dipeptide Bergmann Glial Cell Differentiation Postsynaptic Density Neuronal Ion Channel Clustering Dendritic Spine Maintenance
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