TNNT1 and ZKSCAN5

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		TNNT1	ZKSCAN5
Description		troponin T1, slow skeletal type	zinc finger with KRAB and SCAN domains 5
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Troponin Complex	Nucleus
	Molecular Function	Protein Binding Tropomyosin Binding Troponin T Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Skeletal Muscle Contraction Regulation Of Muscle Contraction Transition Between Fast And Slow Fiber Slow-twitch Skeletal Muscle Fiber Contraction Sarcomere Organization Negative Regulation Of Muscle Contraction	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process
Pathways		Striated Muscle Contraction	Generic Transcription Pathway
Drugs
Diseases		Nemaline myopathy
GWAS		Height ( 31562340)	Dehydroepiandrosterone sulphate levels ( 21533175) Facial emotion recognition (sad faces) ( 28608620) Femoral neck bone mineral density ( 29499414) Hand grip strength ( 29691431) Hormone measurements ( 23696881) Lumbar spine bone mineral density ( 29499414) Serum metabolite levels ( 23093944) Sex hormone levels ( 26014426) Tacrolimus trough concentration in kidney transplant patients ( 29160300) Total body bone mineral density ( 29304378) Urinary metabolite levels in chronic kidney disease ( 31959995) White blood cell count ( 32888494)
Interacting Genes		69 interacting genes: ARMC8 BLOC1S2 BMPR1B CCDC136 CCDC85B CHD3 CLIP4 DDX5 EEF1G FAF1 FXR2 FYN HAP1 HMGXB4 HSP90AB1 IMMT KAT5 KRT27 KRT40 LARP1 LDOC1 MARS1 MORF4L1 MYOM2 NACAD NAGK NFE2L2 NINL NSG2 OSBP2 OSM PI4KA PLEKHF1 PNMA1 PPFIA1 PRKG1 PSMC5 SBK3 SDCBP2 SEC31A SERPINA4 SH3GL3 SMAD1 SMAD2 SMURF1 SNW1 TBPL1 TFIP11 TGFBR1 TMEM98 TNNC1 TNNI1 TNNI2 TNNI3 TNNT2 TPM1 TPM3 TRA2A TRIM63 TSPYL2 TULP3 UBE2D1 VIM WDCP ZC3H15 ZKSCAN5 ZMYND19 ZNF250 ZNF768	7 interacting genes: CRK RBM11 RHOB SUV39H1 TNNT1 ZBTB9 ZSCAN1
Entrez ID		7138	23660
HPRD ID		01841	10318
Ensembl ID		ENSG00000105048	ENSG00000196652
Uniprot IDs		P13805	B3KNK8 Q8N718 Q9Y2L8
PDB IDs			2EM5 2EMM 2EMZ 2EN3 2EOM 2EON 2EOO 2YSO 2YTG
Enriched GO Terms of Interacting Partners?		Troponin Complex Cardiac Muscle Contraction Ventricular Cardiac Muscle Tissue Morphogenesis SMAD Binding Muscle System Process Cardiac Troponin Complex Cardiac Muscle Tissue Morphogenesis Muscle Contraction Troponin T Binding Muscle Filament Sliding I-SMAD Binding Muscle Tissue Morphogenesis Actin-myosin Filament Sliding Striated Muscle Contraction Protein Binding Skeletal Muscle Contraction Primary MiRNA Processing Homomeric SMAD Protein Complex Actin-mediated Cell Contraction Contractile Muscle Fiber Regulation Of Hematopoietic Stem Cell Differentiation Tissue Morphogenesis Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Troponin C Binding Regulation Of Muscle System Process Regulation Of Muscle Contraction Sarcomere Response To Muramyl Dipeptide Regulation Of Primary Metabolic Process Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Troponin I Binding Muscle Thin Filament Tropomyosin Cytosol Actin Filament-based Movement Regulation Of Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Cytoskeleton Organization Transforming Growth Factor Beta Receptor Activity, Type I Disordered Domain Specific Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process R-SMAD Binding Cytoplasm Negative Regulation Of Smooth Muscle Cell Migration Regulation Of Stem Cell Differentiation Calcium-dependent Protein Binding SMAD Protein Complex Trophoblast Cell Migration Transition Between Fast And Slow Fiber Cardiac Myofibril	Response To Hydrogen Peroxide Response To Oxidative Stress Helper T Cell Diapedesis Protein Phosphorylated Amino Acid Binding Response To Cholecystokinin Slow-twitch Skeletal Muscle Fiber Contraction
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