TIAM1 and ATP5MF

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		TIAM1	ATP5MF
Description		TIAM Rac1 associated GEF 1	ATP synthase membrane subunit f
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Membrane Cell-cell Contact Zone Synapse Anchoring Junction	Mitochondrion Mitochondrial Inner Membrane Membrane Nuclear Membrane Proton-transporting ATP Synthase Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Lipid Binding Kinase Binding	Proton-transporting ATP Synthase Activity, Rotational Mechanism
	Biological Process	Cell-matrix Adhesion Signal Transduction Small GTPase-mediated Signal Transduction Positive Regulation Of Cell Population Proliferation Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Epithelial To Mesenchymal Transition Cell Migration Rac Protein Signal Transduction Positive Regulation Of Cell Migration Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Ephrin Receptor Signaling Pathway Positive Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction Wnt Signaling Pathway, Planar Cell Polarity Pathway Protein-containing Complex Assembly Regulation Of Dopaminergic Neuron Differentiation	ATP Biosynthetic Process Monoatomic Ion Transport Proton Motive Force-driven ATP Synthesis Proton Motive Force-driven Mitochondrial ATP Synthesis Proton Transmembrane Transport
Pathways		NRAGE signals death through JNK EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells G alpha (12/13) signalling events RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle Activated NTRK2 signals through CDK5	Formation of ATP by chemiosmotic coupling Cristae formation
Drugs
Diseases
GWAS		Cervical high-risk human papilloma virus infection ( 33225922) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Renal sinus fat ( 22044751) Waist circumference ( 28552196)
Interacting Genes		87 interacting genes: ABCA1 ABCC5 ABTB3 ANK1 AP2M1 ARHGEF10 ARRB1 ATG5 ATP1A2 ATP5MF BTRC CAMK2G CASK CCDC15 CD44 CDC42 CHD9 CREBBP CREBZF CRYAB CSNK1A1 DAAM2 DLG1 DLG4 DNAAF9 DPM1 DZIP1 EFNB1 ENPP5 EPHA2 FNDC3B GART GLUD1 H3-3A H3-3B HRAS HSD17B4 KRIT1 MAPK8IP1 MAPK8IP2 MAST1 MBD1 MYC NASP NEUROD2 NME1 NRBP1 OSBPL1A PARD3 POLR1C PPP1R9B PPP2CA PRKCA PRKCB PRKCD PRKCE PRKCG PRKCZ RAB6A RAC1 RHOA RPL27A RYR3 SENP6 SGTA SHARPIN SMARCE1 SNRNP70 SNTA1 SOX10 SRC SRSF5 SYCP1 TBC1D23 TMED4 TOP1 UBC USP9X YWHAG ZBTB44 ZKSCAN4 ZNF133 ZNF292 ZNF34 ZNF350 ZNF558 ZNF793	15 interacting genes: ARL8B CAPNS1 CCDC137 CDC42 CRELD1 FBP1 HAP1 KDM1A LPP NDUFA6 NECTIN2 PRPF4 RPLP1 TIAM1 ZFPL1
Entrez ID		7074	9551
HPRD ID		02820	16520
Ensembl ID		ENSG00000156299	ENSG00000241468
Uniprot IDs		A0A1B0GW57 A0A2X0TW27 A0A8V8TN84 Q13009	P56134
PDB IDs		2D8I 3KZD 3KZE 4GVC 4GVD 4K2O 4K2P 4NXP 4NXQ 4NXR	8H9F 8H9J 8H9M 8H9Q 8H9S 8H9T 8H9U 8H9V 8KHF 8KI3
Enriched GO Terms of Interacting Partners?		Diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Protein-containing Complex Assembly Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Biogenesis Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Establishment Or Maintenance Of Apical/basal Cell Polarity Positive Regulation Of Cellular Component Organization Intracellular Signal Transduction Intracellular Signaling Cassette Positive Regulation Of Signal Transduction Regulation Of Organelle Organization Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Protein Kinase Activity Regulation Of Cell Projection Assembly Protein Kinase C Signaling Regulation Of Signaling Regulation Of Cell Communication Protein Serine/threonine Kinase Activity Cell-cell Junction Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction Cellular Component Assembly Protein-containing Complex Organization Establishment Or Maintenance Of Cell Polarity Positive Regulation Of Protein Localization Regulation Of Centromere Complex Assembly Regulation Of Protein Localization Regulation Of Protein Localization To Membrane Nucleotide Binding ATP Binding Regulation Of System Process Regulation Of Biological Quality Regulation Of Lamellipodium Organization Regulation Of Cell Projection Organization Negative Regulation Of Metabolic Process Positive Regulation Of Protein-containing Complex Assembly Regulation Of Synaptic Plasticity Positive Regulation Of Organelle Organization Cell Periphery Positive Regulation Of Rho Protein Signal Transduction Organelle Organization Regulation Of Cell Adhesion Ruffle Membrane Protein Serine Kinase Activity Phosphate-containing Compound Metabolic Process Protein-containing Complex Assembly	Organelle Localization Wnt Signaling Pathway, Planar Cell Polarity Pathway Cell-cell Junction Focal Adhesion Establishment Of Organelle Localization Microtubule-based Transport Transport Along Microtubule GBD Domain Binding Storage Vacuole Positive Regulation Of Cell Projection Organization Non-canonical Wnt Signaling Pathway Spindle Midzone Cytoskeleton-dependent Intracellular Transport G Protein Activity Cellular Response To CAMP Phosphoric Ester Hydrolase Activity Cellular Response To Raffinose Fructose 1,6-bisphosphate 1-phosphatase Activity Natural Killer Cell Mediated Immunity Natural Killer Cell Mediated Cytotoxicity Cell-cell Contact Zone Coreceptor-mediated Virion Attachment To Host Cell Cellular Anatomical Entity Morphogenesis Susceptibility To T Cell Mediated Cytotoxicity Sperm Mitochondrion Organization Mitochondrion Localization Positive Regulation Of Neurogenesis Positive Regulation Of Nervous System Development Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Neurotrophin Production Axon Cytoplasm Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Axonal Transport Anterograde Axonal Transport Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Antigen Processing And Presentation Following Phagocytosis Antigen Processing And Presentation Of Polysaccharide Antigen Via MHC Class II Endosome To Lysosome Transport Of Low-density Lipoprotein Particle Viral Exocytosis Regulation Of Plasma Membrane Bounded Cell Projection Organization Endothelin Receptor Signaling Pathway Involved In Heart Process Organelle Transport Along Microtubule Regulation Of Cell Projection Organization Cellular Hypotonic Salinity Response Fusion Of Virus Membrane With Host Plasma Membrane Susceptibility To Natural Killer Cell Mediated Cytotoxicity Leukocyte Mediated Cytotoxicity Brain-derived Neurotrophic Factor Binding Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity
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