THBS2 and THBS3

Number of citations of the paper that reports this interaction (PubMedID 1459996)
0

Data Source:
HPRD (in vitro, in vivo)

		THBS2	THBS3
Description		thrombospondin 2	thrombospondin 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Matrix Platelet Alpha Granule	Extracellular Region Extracellular Matrix Perinuclear Region Of Cytoplasm
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Heparin Binding	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Heparin Binding
	Biological Process	Cell Adhesion Negative Regulation Of Angiogenesis Positive Regulation Of Synapse Assembly	Growth Plate Cartilage Development Cell Adhesion Cell-matrix Adhesion Ossification Involved In Bone Maturation Bone Trabecula Formation
Pathways		Signaling by PDGF Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins	Signaling by PDGF
Drugs
Diseases
GWAS		Anorectal malformation ( 31136621) Blood protein levels ( 30072576) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Carotid intima media thickness x smoking interaction ( 32117412) Central corneal thickness ( 29760442 32528159) Common carotid intima-media thickness in HIV negative individuals ( 29206233) Copper levels ( 26025379) Dimensional psychopathology (Cognitive) ( 29496196) Haemorrhoidal disease ( 33888516) Joint mobility (Beighton score) ( 27182965) Liver disease severity in Alagille syndrome ( 28090565) Obesity-related traits ( 23251661) Pulse pressure ( 27841878 28135244)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 28067908) Mean corpuscular hemoglobin concentration ( 32888494) Occipital lobe volume ( 31396565) Serum cancer antigen 15.3 levels ( 31666285) Serum urea levels ( 30808845) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urinary albumin-to-creatinine ratio ( 26631737) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737)
Interacting Genes		5 interacting genes: MMP2 MMP9 RPS6KA2 THBS3 UBC	1 interacting genes: THBS2
Entrez ID		7058	7059
HPRD ID		01766	01767
Ensembl ID		ENSG00000186340	ENSG00000169231
Uniprot IDs		A0A7I2V585 P35442	F5H4Z8 P49746
PDB IDs		1YO8 2RHP
Enriched GO Terms of Interacting Partners?		Cellular Response To UV-A Bone Trabecula Formation Response To UV-A Collagen Catabolic Process Embryo Implantation Endodermal Cell Differentiation Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Extracellular Matrix Disassembly Ephrin Receptor Signaling Pathway Extracellular Matrix Response To Amyloid-beta Collagen Metabolic Process Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Endopeptidase Activity Cellular Response To UV Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Apoptotic Process Metalloendopeptidase Activity Positive Regulation Of Programmed Cell Death Cellular Response To Light Stimulus Ossification Metallopeptidase Activity Brain Renin-angiotensin System Regulation Of Smooth Muscle Cell Proliferation Serine-type Endopeptidase Activity Response To UV Cellular Response To Radiation Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Response To Oxygen-containing Compound Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Developmental Maturation Intramembranous Ossification Ribosomal Protein S6 Kinase Activity Regulation Of Blood Volume By Renin-angiotensin Extracellular Matrix Organization Blood Vessel Maturation Extracellular Structure Organization Peripheral Nervous System Axon Regeneration Trophoblast Cell Migration Ovulation From Ovarian Follicle Heart Development Luteinization Parturition Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Meiotic Nuclear Division Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Ossification Involved In Bone Maturation Proteolysis Positive Regulation Of Keratinocyte Migration	Positive Regulation Of Cell Junction Assembly Negative Regulation Of Angiogenesis Heparin Binding Positive Regulation Of Synapse Assembly Platelet Alpha Granule Basement Membrane Negative Regulation Of Vasculature Development Extracellular Matrix Structural Constituent Regulation Of Synapse Assembly
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