THBS2

Description		thrombospondin 2
Image
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Matrix Platelet Alpha Granule
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Heparin Binding
	Biological Process	Cell Adhesion Negative Regulation Of Angiogenesis Positive Regulation Of Synapse Assembly
Pathways		Signaling by PDGF Defective B3GALTL causes PpS O-glycosylation of TSR domain-containing proteins
Drugs
Diseases
GWAS		Anorectal malformation ( 31136621) Blood protein levels ( 30072576) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Carotid intima media thickness x smoking interaction ( 32117412) Central corneal thickness ( 29760442 32528159) Common carotid intima-media thickness in HIV negative individuals ( 29206233) Copper levels ( 26025379) Dimensional psychopathology (Cognitive) ( 29496196) Haemorrhoidal disease ( 33888516) Joint mobility (Beighton score) ( 27182965) Liver disease severity in Alagille syndrome ( 28090565) Obesity-related traits ( 23251661) Pulse pressure ( 27841878 28135244)
Novel Interacting Genes		5 novel interacting genes: MMP2 MMP9 RPS6KA2 THBS3 UBC
Interacting Genes		5 interacting genes: MMP2 MMP9 RPS6KA2 THBS3 UBC
Entrez ID		7058
HPRD ID		01766
Ensembl ID		ENSG00000186340
Uniprot IDs		A0A7I2V585 P35442
PDB IDs		1YO8 2RHP
Enriched GO Terms of Interacting Partners?		Cellular Response To UV-A Bone Trabecula Formation Response To UV-A Collagen Catabolic Process Embryo Implantation Endodermal Cell Differentiation Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Extracellular Matrix Disassembly Ephrin Receptor Signaling Pathway Extracellular Matrix Response To Amyloid-beta Collagen Metabolic Process Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Endopeptidase Activity Cellular Response To UV Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Apoptotic Process Metalloendopeptidase Activity Positive Regulation Of Programmed Cell Death Cellular Response To Light Stimulus Ossification Metallopeptidase Activity Brain Renin-angiotensin System Regulation Of Smooth Muscle Cell Proliferation Serine-type Endopeptidase Activity Response To UV Cellular Response To Radiation Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Response To Oxygen-containing Compound Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Developmental Maturation Intramembranous Ossification Ribosomal Protein S6 Kinase Activity Regulation Of Blood Volume By Renin-angiotensin Extracellular Matrix Organization Blood Vessel Maturation Extracellular Structure Organization Peripheral Nervous System Axon Regeneration Trophoblast Cell Migration Ovulation From Ovarian Follicle Heart Development Luteinization Parturition Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Meiotic Nuclear Division Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Ossification Involved In Bone Maturation Proteolysis Positive Regulation Of Keratinocyte Migration
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