TGM3 and HLCS

		TGM3	HLCS
Description		transglutaminase 3	holocarboxylase synthetase
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Protein-containing Complex Extracellular Exosome	Chromatin Nuclear Lamina Cytoplasm Mitochondrion Cytosol Nuclear Matrix
	Molecular Function	Protein-glutamine Gamma-glutamyltransferase Activity Catalytic Activity Structural Molecule Activity Calcium Ion Binding Protein Binding Transferase Activity Acyltransferase Activity Metal Ion Binding	Nucleotide Binding Catalytic Activity Biotin--[biotin Carboxyl-carrier Protein] Ligase Activity Protein Binding ATP Binding Biotin Binding Ligase Activity Enzyme Binding Identical Protein Binding
	Biological Process	Peptide Cross-linking Keratinocyte Differentiation Hair Follicle Morphogenesis Keratinization Protein Modification Process	Biotin Metabolic Process Post-translational Protein Modification Response To Biotin
Pathways			Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency
Drugs		5'-Guanosine-Diphosphate-Monothiophosphate Guanosine-5'-Monophosphate B-2-Octylglucoside Guanosine-5'-Diphosphate	Biotin
Diseases			Holocarboxylase synthetase deficiency
GWAS		Basal cell carcinoma ( 24403052 25855136 27539887 31174203 33549134) Inflammatory skin disease ( 25574825) Keratinocyte cancer (MTAG) ( 31174203) Metabolite levels ( 23823483) Non-melanoma skin cancer ( 29739929)	Developmental language disorder ( 27016271) Developmental language disorder (linguistic errors) ( 27016271) Hematocrit ( 32888494) Hemoglobin ( 32888494) Intracranial aneurysm ( 29531279) Night sleep phenotypes ( 27126917) Red blood cell count ( 32888494) Seasonality and depression ( 30217971)
Interacting Genes		4 interacting genes: CALML5 HLCS HMGB1 UCHL5	19 interacting genes: ACACB ANKRD29 BACH1 DDX52 IFNAR2 IFNGR2 IFT20 KRTAP5-9 LANCL2 MED19 NGB POT1 QKI SARS2 SNX27 SOD1 TGM3 TXNDC15 WIPF1
Entrez ID		7053	3141
HPRD ID		02584	08360
Ensembl ID		ENSG00000125780	ENSG00000159267
Uniprot IDs		Q08188	A0A8C8QSB1 P50747
PDB IDs		1L9M 1L9N 1NUD 1NUF 1NUG 8OXV 8OXW 8OXX 8OXY 8RMX 8RMY
Enriched GO Terms of Interacting Partners?		Biotin--[biotin Carboxyl-carrier Protein] Ligase Activity Biotin Metabolic Process Biotin Binding Response To Biotin Regulation Of Mismatch Repair Negative Regulation Of DNA-templated Transcription Initiation C-X-C Chemokine Binding Alphav-beta3 Integrin-HMGB1 Complex Positive Regulation Of Hematopoietic Progenitor Cell Differentiation Calcium-dependent Protein Kinase Regulator Activity Positive Regulation Of Toll-like Receptor 2 Signaling Pathway T-helper 1 Cell Activation Regulation Of Restriction Endodeoxyribonuclease Activity Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of DNA Repair Positive Regulation Of Mismatch Repair Plasmacytoid Dendritic Cell Activation Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Myeloid Progenitor Cell Differentiation Ficolin-1-rich Granule Lumen DNA Recombination Negative Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Glycogen Catabolic Process Positive Regulation Of DNA Metabolic Process Supercoiled DNA Binding Regulation Of DNA Repair Positive Regulation Of Myeloid Progenitor Cell Differentiation Positive Regulation Of Dendritic Cell Differentiation Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Apoptotic Cell Clearance Neutrophil Clearance DNA Geometric Change Regulation Of Glycogen Catabolic Process Bubble DNA Binding Forebrain Morphogenesis Regulation Of Apoptotic Cell Clearance Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Chromosome Organization Regulation Of Toll-like Receptor 9 Signaling Pathway DNA Topological Change Endothelial Cell Chemotaxis Nuclear Lamina RAGE Receptor Binding Regulation Of T Cell Mediated Immune Response To Tumor Cell T-helper 1 Cell Differentiation DNA Binding, Bending Cellular Response To Interleukin-7 Response To Interleukin-7 Positive Regulation Of Monocyte Chemotactic Protein-1 Production
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