ENG and TGFB3

Number of citations of the paper that reports this interaction (PubMedID 9872992)
0

Data Source:
HPRD (in vivo)

		ENG	TGFB3
Description		endoglin	transforming growth factor beta 3
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GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Nuclear Body Receptor Complex Endothelial Microparticle	Extracellular Region Extracellular Space Plasma Membrane Extracellular Matrix Platelet Alpha Granule Lumen
	Molecular Function	Transmembrane Signaling Receptor Activity Type II Transforming Growth Factor Beta Receptor Binding Protein Binding Galactose Binding Glycosaminoglycan Binding Coreceptor Activity Signaling Receptor Activator Activity Type I Transforming Growth Factor Beta Receptor Binding BMP Binding Identical Protein Binding Protein Homodimerization Activity Activin Binding Transforming Growth Factor Beta Binding	Type II Transforming Growth Factor Beta Receptor Binding Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity Type I Transforming Growth Factor Beta Receptor Binding Type III Transforming Growth Factor Beta Receptor Binding Identical Protein Binding Transforming Growth Factor Beta Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Branching Involved In Blood Vessel Morphogenesis Vasculogenesis Response To Hypoxia Negative Regulation Of Endothelial Cell Proliferation Heart Looping Sprouting Angiogenesis Positive Regulation Of Systemic Arterial Blood Pressure Outflow Tract Septum Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endocardial Cushion Morphogenesis Cardiac Ventricle Morphogenesis Cardiac Atrium Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Cell Migration Involved In Endocardial Cushion Formation Regulation Of DNA-templated Transcription Cell Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Heart Development Negative Regulation Of Gene Expression Regulation Of Cardiac Muscle Cell Apoptotic Process Cell Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Central Nervous System Vasculogenesis Extracellular Matrix Disassembly Regulation Of Cell Adhesion Negative Regulation Of Cell Migration BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of BMP Signaling Pathway Dorsal Aorta Morphogenesis Wound Healing Regulation Of Cell Population Proliferation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Smooth Muscle Tissue Development Artery Morphogenesis Venous Blood Vessel Morphogenesis Cell Motility Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Atrial Cardiac Muscle Tissue Morphogenesis Cell Chemotaxis Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of SMAD Protein Signal Transduction Detection Of Hypoxia Endocardial Cushion To Mesenchymal Transition Vascular Associated Smooth Muscle Cell Development Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Atrioventricular Canal Morphogenesis Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Regulation Of Cell Proliferation Involved In Heart Morphogenesis	Response To Hypoxia In Utero Embryonic Development Transforming Growth Factor Beta Receptor Signaling Pathway Salivary Gland Morphogenesis Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Macrophage Cytokine Production Mammary Gland Development Response To Progesterone Positive Regulation Of Collagen Biosynthetic Process Regulation Of Cell Population Proliferation Odontogenesis Uterine Wall Breakdown Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Cell-cell Junction Organization Positive Regulation Of Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Lung Alveolus Development Positive Regulation Of Protein Secretion Positive Regulation Of Cellular Component Organization Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Filopodium Assembly Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Cell Division Face Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Secondary Palate Development Detection Of Hypoxia Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Tight Junction Disassembly
Pathways			Platelet degranulation Molecules associated with elastic fibres TGF-beta receptor signaling activates SMADs ECM proteoglycans
Drugs		Carotuximab	1,4-Dioxane
Diseases		Hereditary hemorrhagic telangiectasia (HHT)	Arrhythmogenic right ventricular cardiomyopathy (ARVC) Graft-versus-host disease Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate Allograft rejection Ossification of the posterior longitudinal ligament of spine (OPLL)
GWAS		Blood protein levels ( 30072576) Body mass index ( 26426971) Metabolic syndrome ( 20694148) Monocyte count ( 32888494)	Height ( 33713608)
Interacting Genes		16 interacting genes: ACVR1 ACVR2A BMP2 BMP7 CNTRL DYNLT4 GDF2 INHBA LHX2 TGFB1 TGFB2 TGFB3 TGFBR1 TGFBR2 TGFBR3 TRAF1	13 interacting genes: ACVRL1 CCL20 CCN2 CHMP2A ENG FMOD LTBP3 SDC4 TGFB2 TGFBR1 TGFBR2 TGFBR3 VASN
Entrez ID		2022	7043
HPRD ID		00565	01829
Ensembl ID		ENSG00000106991	ENSG00000119699
Uniprot IDs		B7Z6Y5 F5GX88 P17813 Q5T9B9 Q96CG0	A5YM40 B3KVH9 P10600
PDB IDs		5HZV 5HZW 5I04	1KTZ 1TGJ 1TGK 2PJY 3EO1 4UM9 8V52 8VS6 8VSB 9B9F 9FK5
Enriched GO Terms of Interacting Partners?		Positive Regulation Of SMAD Protein Signal Transduction Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Positive Regulation Of Epithelial To Mesenchymal Transition Response To Growth Factor Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Animal Organ Development Type II Transforming Growth Factor Beta Receptor Binding Activin Receptor Signaling Pathway Activin Binding Type III Transforming Growth Factor Beta Receptor Binding Epithelial To Mesenchymal Transition Odontogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Mesenchymal Cell Differentiation Animal Organ Morphogenesis Transforming Growth Factor Beta Binding Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Intracellular Signal Transduction Activin Receptor Complex Activin Receptor Activity, Type I Positive Regulation Of Cell Differentiation Tissue Morphogenesis Heart Development Cardiac Septum Morphogenesis Gland Morphogenesis Growth Factor Activity Cellular Response To BMP Stimulus Positive Regulation Of Developmental Process Roof Of Mouth Development Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition BMP Signaling Pathway Tube Morphogenesis Salivary Gland Morphogenesis Regulation Of Multicellular Organismal Development Anatomical Structure Morphogenesis Ventricular Septum Morphogenesis Transmembrane Receptor Protein Serine/threonine Kinase Activity Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Secondary Palate Development Regulation Of Cell Differentiation Cytokine Activity Positive Regulation Of Signal Transduction	Transforming Growth Factor Beta Binding Activin Binding Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Regulation Of SMAD Protein Signal Transduction Cardiac Epithelial To Mesenchymal Transition Transforming Growth Factor Beta Receptor Activity Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Epithelial To Mesenchymal Transition Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Type II Transforming Growth Factor Beta Receptor Binding Mesenchymal Cell Differentiation Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Artery Morphogenesis Endocardial Cushion Morphogenesis Heart Trabecula Morphogenesis Regulation Of Cartilage Development Cardiac Septum Morphogenesis Enzyme-linked Receptor Protein Signaling Pathway Blood Vessel Morphogenesis Activin Receptor Activity, Type I Regulation Of Epithelial To Mesenchymal Transition Ventricular Septum Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis SMAD Binding Cell Migration Negative Regulation Of Epithelial Cell Proliferation Regulation Of Chondrocyte Differentiation Transmembrane Receptor Protein Serine/threonine Kinase Activity Cardiac Muscle Tissue Morphogenesis Secondary Palate Development Regulation Of Cell Migration Positive Regulation Of Epithelial To Mesenchymal Transition Ventricular Trabecula Myocardium Morphogenesis Cell Surface Regulation Of Cell Motility Cell Motility Regulation Of Locomotion Muscle Tissue Morphogenesis Wound Healing Tissue Morphogenesis Response To Wounding Roof Of Mouth Development Tissue Development Glycosaminoglycan Binding
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