TACR3 and PALS2

		TACR3	PALS2
Description		tachykinin receptor 3	protein associated with LIN7 2, MAGUK p55 family member
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Membrane Neuronal Cell Body Membrane Sperm Midpiece	Plasma Membrane Cell-cell Junction Membrane Organelle Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Activity Tachykinin Receptor Activity Protein Binding	Protein Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Positive Regulation Of Heart Rate Response To Estradiol Regulation Of Dopamine Metabolic Process Response To Cocaine Positive Regulation Of Blood Pressure Regulation Of Feeding Behavior Positive Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Flagellated Sperm Motility	Protein-containing Complex Assembly
Pathways		Tachykinin receptors bind tachykinins G alpha (q) signalling events
Drugs		Osanetant Talnetant Pavinetant
Diseases		Hypogonadotropic hypogonadism; Kallmann syndrome (KAL)
GWAS		Chronotype ( 30696823) Heel bone mineral density ( 30598549) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Menarche (age at onset) ( 25231870 27182965) Rosacea symptom severity ( 29771307) Spontaneous preterm birth without premature rupture of membranes ( 31194736)
Interacting Genes		5 interacting genes: GPRASP1 PALS2 TAC1 TAC3 TAC4	37 interacting genes: AATF ABCA1 ADGRA1 ARF5 ARHGAP18 DIS3 DNM2 DYNLRB1 EIF3G EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FTL KHDRBS1 KNSTRN LIN7A MKRN2 MT2P1 MTREX NDN NFKB1 OGT OSBPL3 PARN PTF1A RPS20 SMARCA4 SNX9 TACR3 THOP1 VPS26C WEE2-AS1
Entrez ID		6870	51678
HPRD ID		01209	09509
Ensembl ID		ENSG00000169836	ENSG00000105926
Uniprot IDs		P29371	B8ZZG1 Q9NZW5
PDB IDs		8JBF 8JBG 8JBH
Enriched GO Terms of Interacting Partners?		Substance K Receptor Binding Tachykinin Receptor Signaling Pathway Positive Regulation Of Flagellated Sperm Motility Positive Regulation Of Cilium Movement Regulation Of Flagellated Sperm Motility Substance P Receptor Binding Neuromedin K Receptor Binding Regulation Of Cilium Movement Regulation Of Microtubule-based Movement Positive Regulation Of Sensory Perception Of Pain Positive Regulation Of Reproductive Process Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Regulation Of Blood Pressure Regulation Of Sensory Perception Of Pain Regulation Of Reproductive Process Detection Of Temperature Stimulus Involved In Sensory Perception Negative Regulation Of Systemic Arterial Blood Pressure Detection Of Temperature Stimulus Regulation Of Microtubule-based Process Negative Regulation Of Blood Pressure Neuropeptide Signaling Pathway Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Nervous System Process Detection Of Abiotic Stimulus Receptor Ligand Activity G Protein-coupled Receptor Catabolic Process Detection Of Stimulus Involved In Sensory Perception Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Temperature Stimulus G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Corticosterone Secretion Negative Regulation Of Sensory Perception Of Pain Insemination Regulation Of Corticosterone Secretion Regulation Of Cell Motility Positive Regulation Of Synaptic Transmission, Cholinergic Detection Of Stimulus Regulation Of Locomotion Positive Regulation Of Action Potential Antifungal Humoral Response Negative Regulation Of Heart Rate Response To Yeast Positive Regulation Of Synaptic Transmission, GABAergic Response To Pain Extracellular Space Receptor Catabolic Process Negative Regulation Of Nervous System Process Negative Regulation Of Heart Contraction Neuronal Dense Core Vesicle	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Nucleolar Exosome (RNase Complex) Nuclear MRNA Surveillance RNA Exonuclease Activity U4 SnRNA 3'-end Processing Nuclear RNA Surveillance RNA Surveillance 3'-5'-RNA Exonuclease Activity RRNA Catabolic Process SnRNA Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process SnRNA 3'-end Processing RNA 3'-end Processing MRNA Catabolic Process RNA Catabolic Process Exoribonuclease Complex SnRNA Processing Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process Sno(s)RNA Metabolic Process RRNA 3'-end Processing TRNA Decay RRNA Processing RRNA Metabolic Process Nucleobase-containing Compound Catabolic Process MRNA Metabolic Process RNA Binding U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Nucleolus RNA Metabolic Process CUT Catabolic Process RNA Processing Negative Regulation Of Gene Expression MRNA 3'-UTR AU-rich Region Binding Macromolecule Catabolic Process DNA Deamination Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleic Acid Metabolic Process Maturation Of 5.8S RRNA Cytoplasm Catabolic Process DNA Modification Negative Regulation Of Macromolecule Metabolic Process
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