SVIL and MIF4GD

Number of citations of the paper that reports this interaction (PubMedID 20309963)
81

Data Source:
BioGRID (two hybrid)

		SVIL	MIF4GD
Description		supervillin	MIF4G domain containing
Image			No pdb structure
GO Annotations	Cellular Component	Podosome Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Actin Cytoskeleton Membrane Midbody Cleavage Furrow Microtubule Minus-end Cell Projection Costamere Anchoring Junction	Nucleus Nucleolus Cytoplasm Golgi Apparatus Cytosol Histone MRNA Stem-loop Binding Complex
	Molecular Function	Actin Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Actin Filament Binding	RNA Binding Protein Binding Translation Activator Activity Identical Protein Binding
	Biological Process	Cytoskeleton Organization Skeletal Muscle Tissue Development Actin Polymerization Or Depolymerization Positive Regulation Of Cytokinesis Actin Filament Severing Barbed-end Actin Filament Capping Muscle Structure Development	Cap-dependent Translational Initiation Regulation Of Translation Regulation Of Translational Initiation Positive Regulation Of Translation
Pathways
Drugs
Diseases
GWAS		Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Bone fracture in osteoporosis ( 28580392) Dilated cardiomyopathy ( 33495596) Dilated cardiomyopathy (MTAG) ( 33495596) Estimated glomerular filtration rate ( 31152163) Lung function (FEV1/FVC) ( 28166213) Metabolite levels ( 23823483) Neurofibrillary tangles ( 25188341) Normalized brain volume ( 19010793) Platelet thrombus formation ( 22550155) Plateletcrit ( 32888494)
Interacting Genes		37 interacting genes: AR ATRX BUB1 CENPF DYNLT1 ESR1 FLNA HAX1 HMMR HSP90AA1 ITGB3BP KIF22 KIFC3 KMT2A KRT18 LMNA LMNB2 LUC7L2 MIF4GD MPHOSPH9 MRTFB NME2 NR3C1 ODF2 P2RX7 PAN3 PCNX3 PPARG SH3PXD2A SLAMF7 STARD9 TGFB1I1 TMEM132D TNFAIP1 TRIP6 UXT YWHAG	21 interacting genes: AQP1 ATPAF2 CFAP206 CHCHD2 CRYBA4 DDIAS DDX19A EIF3G ENKD1 EXOSC6 FAM110A HDAC4 HGS HINFP MKRN3 NTAQ1 PDE4DIP PPARG SMARCB1 SVIL UBQLN4
Entrez ID		6840	57409
HPRD ID		04992	10629
Ensembl ID		ENSG00000197321	ENSG00000125457
Uniprot IDs		A0A6I8PIX7 O95425 Q569J5	A0A0S2Z5K9 A0A0S2Z5S7 A0A0S2Z5T5 A9UHW6 J3KSB8 J3QLJ5
PDB IDs		2K6M 2K6N
Enriched GO Terms of Interacting Partners?		Organelle Organization Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Estrogen Response Element Binding Cytoskeleton Identical Protein Binding Nucleus Regulation Of Organelle Organization Nuclear Receptor Activity Positive Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Metabolic Process Cytoplasm Regulation Of Apoptotic Process Steroid Binding Regulation Of Programmed Cell Death Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Pore Localization Chromatin Binding Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor-mediated Signaling Pathway Apoptotic Process Regulation Of Cellular Component Organization Positive Regulation Of Macromolecule Metabolic Process Cytosol Cell Death Programmed Cell Death Nitric-oxide Synthase Regulator Activity Positive Regulation Of Macromolecule Biosynthetic Process Spindle Regulation Of Gene Expression Regulation Of Chromosome Organization Nuclear Matrix Cytoskeleton Organization Prostate Gland Growth Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Intracellular Protein Localization Chromosome Segregation Microtubule Binding Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Microtubule-based Process Microtubule Motor Activity Hormone-mediated Signaling Pathway Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Response To Estrogen Chromatin Organization Nuclear Lamina Microtubule Cytoskeleton Organization Negative Regulation Of Apoptotic Process
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