STAT4 and NMI

Number of citations of the paper that reports this interaction (PubMedID 9989503)
0

Data Source:
HPRD (in vitro)

		STAT4	NMI
Description		signal transducer and activator of transcription 4	N-myc and STAT interactor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body RNA Polymerase II Transcription Regulator Complex	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Defense Response Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Cytokine-mediated Signaling Pathway Interleukin-12-mediated Signaling Pathway Regulation Of Cell Population Proliferation Response To Peptide Hormone T-helper 1 Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Response To Interleukin-6	Macrophage Activation Involved In Immune Response Immune System Process Cell Surface Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Cell Population Proliferation Response To Virus Negative Regulation Of Type I Interferon Production Negative Regulation Of Interferon-alpha Production Negative Regulation Of Interferon-beta Production Toll-like Receptor 4 Signaling Pathway Innate Immune Response Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Negative Regulation Of Innate Immune Response Positive Regulation Of Inflammatory Response Protein K48-linked Ubiquitination Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Protein K48-linked Ubiquitination
Pathways		Interleukin-20 family signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Interleukin-35 Signalling Interleukin-12 signaling Interleukin-12 signaling Interleukin-23 signaling Interleukin-21 signaling Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	SARS-CoV-1 activates/modulates innate immune responses
Drugs
Diseases
GWAS		Arthritis (juvenile idiopathic) ( 33106285) Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Behcet's disease ( 23291587 23001997) Celiac disease ( 22057235 30572963 25920553) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Eosinophil count ( 32888494) Gamma glutamyl transferase levels ( 29403010) Generalized epilepsy ( 30531953) Hepatocellular carcinoma in hepatitis B infection ( 23242368) Idiopathic inflammatory myopathy ( 26362759) Inflammatory bowel disease ( 23128233) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Limited cutaneous systemic scleroderma ( 29293537) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 24076602 31604244) Nontyphoidal Salmonella bacteraemia ( 29523850) Primary biliary cholangitis ( 26394269 28425483 23000144 21399635) Primary biliary cirrhosis ( 22961000) Rheumatoid arthritis ( 30572963 23143596 24390342 32723749 30423114 20453841) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Sjögren's syndrome ( 28076899 24097067 24097066) Systemic lupus erythematosus ( 32771030 28714469 33272962 19165918 23273568 18204098 19838193 19838195 21408207 23053960 24871463 26316170 26606652 26502338 27399966 26663301) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 28314753 33069728 20383147 29293537 21750679 31672989 21779181 30572963 24387989) Systemic sclerosis (anti-centromere-positive) ( 29293537) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Type 1 diabetes ( 34127860) Vitiligo ( 27723757)
Interacting Genes		23 interacting genes: ADRB2 CADM3 CCDC85A CLPP CREBBP CRK DNAH7 HNRNPCP2 IL12RB1 IL12RB2 JUN LY86 MAP2K6 MAPK14 NABP1 NEMP2 NMI PIAS2 PTMS SH2D1B STAT3 TMEFF2 ZNF467	59 interacting genes: ANKRD13C-DT BRAT1 BRCA1 BRMS1 C1orf216 CDKN2A CDKN2D CNKSR3 CNOT7 COPS7B CYP2E1 EMILIN1 EPC2 EXOSC5 GART GCSH GOLGA8EP HDDC3 HGS HOXC9 HSPA8 HSPH1 IFI35 KDM1A LCA5L LSM4 MAD2L1BP MCPH1 MORF4L1 MTMR6 MTMR9 MYC MYCN MYOM3 NECAP2 POMZP3 PSMA1 RYBP SCEL SFR1 SH3GLB2 SINHCAF SNAPC5 SOX10 STAT1 STAT3 STAT4 STAT5A STAT5B STAT6 THAP8 TRAF5 TRIM72 TRIP12 TUBA3C TUBA3E TXLNA TXLNB UBE2I
Entrez ID		6775	9111
HPRD ID		02779	04632
Ensembl ID		ENSG00000138378	ENSG00000123609
Uniprot IDs		Q14765	Q13287
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Defense Response Immune System Process Cell Surface Receptor Signaling Pathway Interleukin-23-mediated Signaling Pathway Response To Stress NLRP1 Inflammasome Complex Assembly Leukocyte Activation Involved In Immune Response Cell Activation Involved In Immune Response Interleukin-12-mediated Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Energy Homeostasis Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Immune Response Cellular Response To UV-B MAP Kinase Kinase Activity Cell Activation T-helper 1 Cell Differentiation Cellular Response To UV Regulation Of Innate Immune Response Positive Regulation Of Defense Response Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Light Stimulus Response To UV-B Stress-activated MAPK Cascade Negative Regulation Of Defense Response P38MAPK Cascade Stress-activated Protein Kinase Signaling Cascade SMAD Protein Signal Transduction Response To Muscle Stretch Positive Regulation Of Innate Immune Response Positive Regulation Of Signal Transduction Intracellular Signaling Cassette Regulation Of Immune System Process Response To Peptide Leukocyte Activation Canonical Inflammasome Complex Assembly Positive Regulation Of Erythrocyte Differentiation Temperature Homeostasis Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Signal Transduction Positive Regulation Of Mini Excitatory Postsynaptic Potential Response To UV Lipopolysaccharide-mediated Signaling Pathway T-helper Cell Differentiation Interleukin-12 Receptor Activity Negative Regulation Of Integrin Biosynthetic Process Cellular Response To Radiation Enzyme-linked Receptor Protein Signaling Pathway Pyroptotic Inflammatory Response Leukocyte Differentiation	Nucleoplasm Cell Surface Receptor Signaling Pathway Via JAK-STAT Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Growth Hormone Receptor Signaling Pathway Interleukin-9-mediated Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Cell Population Proliferation RNA Polymerase II Transcription Regulator Complex Negative Regulation Of RNA Metabolic Process Negative Regulation Of Developmental Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleic Acid Metabolic Process Regulation Of Programmed Cell Death Regulation Of Erythrocyte Differentiation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cell Population Proliferation Development Of Secondary Female Sexual Characteristics Development Of Secondary Male Sexual Characteristics DNA-binding Transcription Factor Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Sin3-type Complex Regulation Of Apoptotic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Differentiation DNA-templated Transcription Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Negative Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Development Of Secondary Sexual Characteristics Positive Regulation Of Gene Expression Regulation Of Myeloid Cell Apoptotic Process Positive Regulation Of Metabolic Process
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