NMI and THAP8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NMI	THAP8
Description		N-myc and STAT interactor	THAP domain containing 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Membrane
	Molecular Function	Protein Binding Identical Protein Binding	DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Macrophage Activation Involved In Immune Response Immune System Process Cell Surface Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Cell Population Proliferation Response To Virus Negative Regulation Of Type I Interferon Production Negative Regulation Of Interferon-alpha Production Negative Regulation Of Interferon-beta Production Toll-like Receptor 4 Signaling Pathway Innate Immune Response Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Negative Regulation Of Innate Immune Response Positive Regulation Of Inflammatory Response Protein K48-linked Ubiquitination Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Protein K48-linked Ubiquitination
Pathways		SARS-CoV-1 activates/modulates innate immune responses
Drugs
Diseases
GWAS
Interacting Genes		59 interacting genes: ANKRD13C-DT BRAT1 BRCA1 BRMS1 C1orf216 CDKN2A CDKN2D CNKSR3 CNOT7 COPS7B CYP2E1 EMILIN1 EPC2 EXOSC5 GART GCSH GOLGA8EP HDDC3 HGS HOXC9 HSPA8 HSPH1 IFI35 KDM1A LCA5L LSM4 MAD2L1BP MCPH1 MORF4L1 MTMR6 MTMR9 MYC MYCN MYOM3 NECAP2 POMZP3 PSMA1 RYBP SCEL SFR1 SH3GLB2 SINHCAF SNAPC5 SOX10 STAT1 STAT3 STAT4 STAT5A STAT5B STAT6 THAP8 TRAF5 TRIM72 TRIP12 TUBA3C TUBA3E TXLNA TXLNB UBE2I	7 interacting genes: DYNLL1 NMI SETDB1 TFIP11 TMED9 TP53 WDR62
Entrez ID		9111	199745
HPRD ID		04632	15501
Ensembl ID		ENSG00000123609	ENSG00000161277
Uniprot IDs		Q13287	B4DKM9 H9CWI5 Q8NA92
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleoplasm Cell Surface Receptor Signaling Pathway Via JAK-STAT Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Growth Hormone Receptor Signaling Pathway Interleukin-9-mediated Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Cell Population Proliferation RNA Polymerase II Transcription Regulator Complex Negative Regulation Of RNA Metabolic Process Negative Regulation Of Developmental Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleic Acid Metabolic Process Regulation Of Programmed Cell Death Regulation Of Erythrocyte Differentiation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Cell Population Proliferation Development Of Secondary Female Sexual Characteristics Development Of Secondary Male Sexual Characteristics DNA-binding Transcription Factor Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Sin3-type Complex Regulation Of Apoptotic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Differentiation DNA-templated Transcription Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Negative Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Development Of Secondary Sexual Characteristics Positive Regulation Of Gene Expression Regulation Of Myeloid Cell Apoptotic Process Positive Regulation Of Metabolic Process	Negative Regulation Of DNA Metabolic Process Negative Regulation Of DNA Replication Regulation Of DNA Metabolic Process Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Promoter-specific Chromatin Binding Negative Regulation Of Pentose-phosphate Shunt Organelle Organization Regulation Of Neuroblast Proliferation Negative Regulation Of Helicase Activity Oxidative Stress-induced Premature Senescence Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Site Of Double-strand Break Regulation Of DNA Replication Negative Regulation Of G1 To G0 Transition Glucose Catabolic Process To Lactate Via Pyruvate Negative Regulation Of Macromolecule Metabolic Process Germ Cell Nucleus Cellular Response To Actinomycin D Regulation Of Neural Precursor Cell Proliferation Deoxyribonuclease Inhibitor Activity Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity Positive Regulation Of Protein K48-linked Ubiquitination Spliceosomal Complex Disassembly U2-type Post-mRNA Release Spliceosomal Complex Negative Regulation Of Metabolic Process Centrosome Histone Deacetylase Regulator Activity Positive Regulation Of Thymocyte Apoptotic Process Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Response To Actinomycin D T Cell Proliferation Involved In Immune Response Cell Activation Involved In Immune Response Regulation Of G1 To G0 Transition Leukocyte Activation Involved In Immune Response Glial Cell Apoptotic Process Cellular Response To UV-C Negative Regulation Of Phosphate Metabolic Process ATP-dependent DNA/DNA Annealing Activity Negative Regulation Of Interferon-alpha Production Histone H3K9 Trimethyltransferase Activity DNA Metabolic Process B Cell Lineage Commitment Regulation Of Pentose-phosphate Shunt Regulation Of Protein K48-linked Ubiquitination Histone H3K9 Monomethyltransferase Activity COPI Coating Of Golgi Vesicle
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