SPAST and IST1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down)

		SPAST	IST1
Description		spastin	IST1 factor associated with ESCRT-III
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GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Centrosome Spindle Cytosol Cytoskeleton Microtubule Microtubule Cytoskeleton Membrane Axon Midbody Cytoplasmic Vesicle Nuclear Membrane Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome Endoplasmic Reticulum Tubular Network Axon Cytoplasm	Chromatin Extracellular Region Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Centrosome Cytosol Cytoskeleton Midbody Cytoplasmic Vesicle Azurophil Granule Lumen Extracellular Exosome Flemming Body
	Molecular Function	Nucleotide Binding Catalytic Activity Protein Binding ATP Binding Microtubule Binding Microtubule Severing ATPase Activity Isomerase Activity ATP Hydrolysis Activity Alpha-tubulin Binding Protein-containing Complex Binding Beta-tubulin Binding	Protein Binding Protein Domain Specific Binding Identical Protein Binding Protein-containing Complex Binding Cadherin Binding MIT Domain Binding
	Biological Process	Mitotic Cytokinesis Microtubule Bundle Formation Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Mitotic Nuclear Membrane Reassembly Nervous System Development Axonogenesis Anterograde Axonal Transport Exit From Mitosis Axonal Transport Of Mitochondrion Central Nervous System Neuron Axonogenesis Cell Differentiation Positive Regulation Of Microtubule Depolymerization Nuclear Membrane Reassembly Positive Regulation Of Cytokinesis Cytokinetic Process Protein Hexamerization Microtubule Severing Mitotic Spindle Disassembly Protein Homooligomerization Cell Division Cytoskeleton-dependent Cytokinesis Membrane Fission	Intracellular Protein Localization Protein Transport Multivesicular Body Assembly Establishment Of Protein Localization Positive Regulation Of Proteolysis Collateral Sprouting Positive Regulation Of Collateral Sprouting Cell Division Cytoskeleton-dependent Cytokinesis Midbody Abscission ESCRT III Complex Disassembly
Pathways		Sealing of the nuclear envelope (NE) by ESCRT-III	Neutrophil degranulation Sealing of the nuclear envelope (NE) by ESCRT-III
Drugs
Diseases		Hereditary spastic paraplegia (SPG)
GWAS		Apolipoprotein A1 levels ( 32203549) Bisphosphonate-associated atypical femoral fracture ( 31006051) Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 31584380) Male-pattern baldness ( 28196072)	Apolipoprotein B levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intelligence (MTAG) ( 29326435) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		11 interacting genes: CEBPA CHMP1B CSNK2A1 DCAF8 FBXL17 IST1 OGT RIPK4 RTN1 SSNA1 USP20	12 interacting genes: APEH ATXN1 BAG4 CALB2 CAPN7 DSCAM OGT SPAST TOX3 UBQLN1 UBQLN2 WWP2
Entrez ID		6683	9798
HPRD ID		05044	13784
Ensembl ID		ENSG00000021574	ENSG00000182149
Uniprot IDs		A0A2R8Y4I8 A0A2R8YFW8 A0A2U3TZR0 E5KRP5 E5KRP6 Q9UBP0	B4DXC9 P53990
PDB IDs		3EAB 3VFD 5Z6Q 5Z6R 6PEK 6PEN 7S7J	3FRR 3FRS 3JC1 4U7E 4U7I 4U7Y 4WZX 6E8G 6TZ4 6TZ5 6TZA 7S7J 8UC6 8V2Q 8V2R 8V2S
Enriched GO Terms of Interacting Partners?		MIT Domain Binding ESCRT III Complex Disassembly ESCRT Complex Disassembly Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Sin3-type Complex Midbody Abscission Regulation Of Ubiquitin-dependent Protein Catabolic Process Midbody Mitotic Cytokinetic Process Multivesicular Body Organization Multivesicular Body Assembly Positive Regulation Of Proteolysis Organelle Organization Regulation Of Proteasomal Protein Catabolic Process Cytokinetic Process Protein Domain Specific Binding Negative Regulation Of Translational Initiation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Axon Arborization Autophagy Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Organelle Assembly Positive Regulation Of Protein Metabolic Process Response To Vitamin B2 C/EBP Complex Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Endosome Organization Chromatin DNA Binding Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Protein Localization To Vacuole CHOP-C/EBP Complex Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Protein O-acetylglucosaminyltransferase Activity Regulation Of Translational Initiation White Fat Cell Proliferation Negative Regulation Of Protein Catabolic Process Developmental Cell Growth Cell Division Identical Protein Binding Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Intracellular Protein Localization Positive Regulation Of Aggrephagy	Proteolysis Cytosol Positive Regulation Of ERAD Pathway Negative Regulation Of Transporter Activity Regulation Of ERAD Pathway Social Behavior Positive Regulation Of Proteolysis Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of MRNA Modification Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Store-operated Calcium Channel Activity Dendriole Calcium Ion Binding Involved In Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Nucleus Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Autophagy Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Autophagosome Negative Regulation Of G Protein-coupled Receptor Internalization Omega Peptidase Activity Mitotic Spindle Disassembly Chromatin DNA Binding Regulation Of Protein Catabolic Process Regulation Of Proteolysis Protein O-acetylglucosaminyltransferase Activity MIT Domain Binding Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Assembly ERAD Pathway Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Monoatomic Ion Transport Autophagosome Organization POZ Domain Binding Negative Regulation Of Transport Negative Regulation Of Transmembrane Transport Negative Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Metabolic Process Positive Regulation Of Axon Extension Involved In Axon Guidance Cellular Component Assembly Positive Regulation Of Microtubule Depolymerization Microtubule Severing ATPase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose
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