SPAST and CHMP1B

Number of citations of the paper that reports this interaction (PubMedID 20719964)
40

Data Source:
BioGRID (two hybrid, pull down)

		SPAST	CHMP1B
Description		spastin	charged multivesicular body protein 1B
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GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Centrosome Spindle Cytosol Cytoskeleton Microtubule Microtubule Cytoskeleton Membrane Axon Midbody Cytoplasmic Vesicle Nuclear Membrane Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome Endoplasmic Reticulum Tubular Network Axon Cytoplasm	Autophagosome Membrane Kinetochore ESCRT III Complex Nuclear Pore Nucleoplasm Cytoplasm Lysosomal Membrane Endosome Multivesicular Body Kinetochore Microtubule Cytosol Plasma Membrane Endosome Membrane Membrane Membrane Coat Midbody Late Endosome Membrane Multivesicular Body Membrane Extracellular Exosome Amphisome Membrane
	Molecular Function	Nucleotide Binding Catalytic Activity Protein Binding ATP Binding Microtubule Binding Microtubule Severing ATPase Activity Isomerase Activity ATP Hydrolysis Activity Alpha-tubulin Binding Protein-containing Complex Binding Beta-tubulin Binding	Protein Binding Protein Domain Specific Binding Identical Protein Binding MIT Domain Binding
	Biological Process	Mitotic Cytokinesis Microtubule Bundle Formation Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Mitotic Nuclear Membrane Reassembly Nervous System Development Axonogenesis Anterograde Axonal Transport Exit From Mitosis Axonal Transport Of Mitochondrion Central Nervous System Neuron Axonogenesis Cell Differentiation Positive Regulation Of Microtubule Depolymerization Nuclear Membrane Reassembly Positive Regulation Of Cytokinesis Cytokinetic Process Protein Hexamerization Microtubule Severing Mitotic Spindle Disassembly Protein Homooligomerization Cell Division Cytoskeleton-dependent Cytokinesis Membrane Fission	Plasma Membrane Repair Autophagy Nucleus Organization Vacuolar Transport Mitotic Metaphase Chromosome Alignment Regulation Of Centrosome Duplication Protein Transport Nuclear Membrane Reassembly Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Establishment Of Protein Localization Late Endosome To Vacuole Transport Viral Budding From Plasma Membrane Cell Division Vesicle Fusion With Vacuole Multivesicular Body-lysosome Fusion Midbody Abscission Multivesicular Body Sorting Pathway Membrane Fission Autophagosome Maturation Regulation Of Mitotic Spindle Assembly Late Endosome To Lysosome Transport ESCRT III Complex Disassembly
Pathways		Sealing of the nuclear envelope (NE) by ESCRT-III
Drugs
Diseases		Hereditary spastic paraplegia (SPG)
GWAS		Apolipoprotein A1 levels ( 32203549) Bisphosphonate-associated atypical femoral fracture ( 31006051) Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 31584380) Male-pattern baldness ( 28196072)	Metabolite levels ( 23823483)
Interacting Genes		11 interacting genes: CEBPA CHMP1B CSNK2A1 DCAF8 FBXL17 IST1 OGT RIPK4 RTN1 SSNA1 USP20	19 interacting genes: CHMP1A CHMP4B CHMP5 CNOT10 KNSTRN MITD1 PICK1 RAB11A RASSF7 SNCA SNRNP200 SPAST SSRP1 STAMBP SUCLG1 USP54 USP8 VPS4A VPS4B
Entrez ID		6683	57132
HPRD ID		05044	12106
Ensembl ID		ENSG00000021574	ENSG00000255112
Uniprot IDs		A0A2R8Y4I8 A0A2R8YFW8 A0A2U3TZR0 E5KRP5 E5KRP6 Q9UBP0	Q7LBR1
PDB IDs		3EAB 3VFD 5Z6Q 5Z6R 6PEK 6PEN 7S7J	3EAB 3JC1 4TXQ 4TXR 6E8G 6TZ4 6TZ5 6TZ9 8V2Q 8V2R 8V2S
Enriched GO Terms of Interacting Partners?		MIT Domain Binding ESCRT III Complex Disassembly ESCRT Complex Disassembly Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Sin3-type Complex Midbody Abscission Regulation Of Ubiquitin-dependent Protein Catabolic Process Midbody Mitotic Cytokinetic Process Multivesicular Body Organization Multivesicular Body Assembly Positive Regulation Of Proteolysis Organelle Organization Regulation Of Proteasomal Protein Catabolic Process Cytokinetic Process Protein Domain Specific Binding Negative Regulation Of Translational Initiation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Axon Arborization Autophagy Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Organelle Assembly Positive Regulation Of Protein Metabolic Process Response To Vitamin B2 C/EBP Complex Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Endosome Organization Chromatin DNA Binding Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process Protein Localization To Vacuole CHOP-C/EBP Complex Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Protein O-acetylglucosaminyltransferase Activity Regulation Of Translational Initiation White Fat Cell Proliferation Negative Regulation Of Protein Catabolic Process Developmental Cell Growth Cell Division Identical Protein Binding Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Intracellular Protein Localization Positive Regulation Of Aggrephagy	Cytokinetic Process Viral Budding Via Host ESCRT Complex Midbody Abscission Viral Budding Nuclear Membrane Reassembly Mitotic Cytokinetic Process Multivesicular Body Assembly Multivesicular Body Organization Viral Budding From Plasma Membrane Endosome Organization Cytoskeleton-dependent Cytokinesis Membrane Fission Mitotic Metaphase Chromosome Alignment Late Endosome To Lysosome Transport Midbody Nuclear Membrane Organization Multivesicular Body Sorting Pathway Metaphase Chromosome Alignment Membrane Assembly Mitotic Cytokinesis Viral Release From Host Cell Plasma Membrane Repair Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Chromosome Localization ESCRT III Complex Disassembly ESCRT Complex Disassembly Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway Endosome Autophagosome Maturation Kinetochore Microtubule Protein-containing Complex Disassembly Viral Process Membrane Organization Regulation Of Mitotic Spindle Assembly Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Organelle Localization Regulation Of Microtubule Cytoskeleton Organization Vesicle Organization Nuclear Pore Nucleus Organization Regulation Of Spindle Assembly Regulation Of Mitotic Spindle Organization Multivesicular Body ESCRT III Complex Plasma Membrane Organization Amphisome Membrane Vesicle Fusion With Vacuole Lysosomal Transport Regulation Of Centrosome Duplication
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