SOS2 and SNX18

Number of citations of the paper that reports this interaction (PubMedID 14679214)
0

Data Source:
HPRD (in vitro)

		SOS2	SNX18
Description		SOS Ras/Rho guanine nucleotide exchange factor 2	sorting nexin 18
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane	Endosome Plasma Membrane Cytoplasmic Side Of Plasma Membrane Endosome Membrane Endomembrane System Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Recycling Endosome Membrane Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Heterodimerization Activity	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Lipid Binding Phosphatidylinositol Binding
	Biological Process	B Cell Homeostasis Lymphocyte Homeostasis Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Insulin Receptor Signaling Pathway Regulation Of T Cell Differentiation In Thymus Regulation Of T Cell Proliferation Regulation Of Pro-B Cell Differentiation	Mitotic Cell Cycle Mitotic Cytokinesis Endocytosis Positive Regulation Of Catabolic Process Protein Transport Endosomal Transport Cleavage Furrow Formation Positive Regulation Of GTPase Activity Cell Division Plasma Membrane Tubulation Positive Regulation Of Autophagosome Assembly
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events Activation of RAC1 Interleukin-15 signaling RAC1 GTPase cycle	Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Birth weight ( 31043758) Erythema nodosum in inflammatory bowel disease ( 24487271) Estimated glomerular filtration rate ( 31015462) Hemoglobin ( 32888494) Intraocular pressure ( 29617998 29785010 30054594 31959993) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Periodontal disease-related phenotype (Socransky) ( 24347629) Pulse pressure ( 30578418) Red blood cell count ( 32888494)	Immune response to smallpox vaccine (IL-6) ( 22542470)
Interacting Genes		20 interacting genes: ABI1 ABL1 BIN1 CD2AP CREBBP CRKL DSCAM EGFR GRAP2 GRB2 HRAS ITSN1 ITSN2 PACSIN3 PLCG1 SH3D19 SHC1 SNX18 SNX9 UBASH3A	20 interacting genes: ABI2 ANKRD55 CPSF7 CYSRT1 DPPA4 GABARAP GOLGA2 HSF2BP HSPB2 HSPB2-C11orf52 KHDRBS3 KRTAP1-1 KRTAP6-3 MAP1LC3B MDFI MSS51 PTPN21 SOS1 SOS2 ZBTB42
Entrez ID		6655	112574
HPRD ID		03149	15407
Ensembl ID		ENSG00000100485	ENSG00000178996
Uniprot IDs		Q07890	Q96RF0
PDB IDs		6EIE 8T5G 8T5M 8T5R 8UC9 8UF2 8UH0 9BVE 9BVF 9BVI 9GIN
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Endocytosis Phosphotyrosine Residue Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Import Into Cell Enzyme-linked Receptor Protein Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin TRKA Receptor Binding Immune Response-activating Signaling Pathway T Cell Receptor Signaling Pathway Intracellular Signaling Cassette Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Cellular Component Organization Plasma Membrane Tubulation Positive Regulation Of Membrane Protein Ectodomain Proteolysis Plasma Membrane Intracellular Signal Transduction Response To Growth Factor Cytosol Proline-rich Region Binding Lipid Tube Assembly Shc-EGFR Complex Clathrin-dependent Synaptic Vesicle Endocytosis Intracellular Vesicle Regulation Of Actin Cytoskeleton Organization Ras Protein Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Vesicle-mediated Transport Cell Surface Receptor Signaling Pathway Regulation Of Actin Filament-based Process Regulation Of Membrane Protein Ectodomain Proteolysis Ephrin Receptor Binding MAPK Cascade Regulation Of MAPK Cascade Regulation Of Immune Response Ruffle Positive Regulation Of Immune Response Cytoplasm Epidermal Growth Factor Binding Small GTPase-mediated Signal Transduction Synaptic Vesicle Endocytosis Cellular Response To Growth Factor Stimulus Endosome Regulation Of ERK1 And ERK2 Cascade Presynaptic Endocytosis Positive Regulation Of Cellular Component Biogenesis	Regulation Of Pro-B Cell Differentiation Regulation Of Lymphoid Progenitor Cell Differentiation Mitophagy Autophagy Of Mitochondrion Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding SH3 Domain Binding Regulation Of T Cell Differentiation In Thymus B Cell Homeostasis Macroautophagy Regulation Of Hematopoietic Progenitor Cell Differentiation
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