SNX18 and PTPN21

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SNX18	PTPN21
Description		sorting nexin 18	protein tyrosine phosphatase non-receptor type 21
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Plasma Membrane Cytoplasmic Side Of Plasma Membrane Endosome Membrane Endomembrane System Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Recycling Endosome Membrane Extracellular Exosome	Cytoplasm Cytoskeleton
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Lipid Binding Phosphatidylinositol Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity
	Biological Process	Mitotic Cell Cycle Mitotic Cytokinesis Endocytosis Positive Regulation Of Catabolic Process Protein Transport Endosomal Transport Cleavage Furrow Formation Positive Regulation Of GTPase Activity Cell Division Plasma Membrane Tubulation Positive Regulation Of Autophagosome Assembly	Protein Dephosphorylation
Pathways		Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Immune response to smallpox vaccine (IL-6) ( 22542470)	Prudent dietary pattern ( 28644415) Suicidality in mood disorders ( 33783297) Suicide attempt severity in mood disorders ( 33783297)
Interacting Genes		20 interacting genes: ABI2 ANKRD55 CPSF7 CYSRT1 DPPA4 GABARAP GOLGA2 HSF2BP HSPB2 HSPB2-C11orf52 KHDRBS3 KRTAP1-1 KRTAP6-3 MAP1LC3B MDFI MSS51 PTPN21 SOS1 SOS2 ZBTB42	28 interacting genes: AKAP1 ATOSB BAG3 BMX CATSPER1 CWC22 ERBB4 FBXO17 GOLGA2 KIF1C MAGOHB MOB3C NEK6 NSMF PAK5 PARD6A PIBF1 QARS1 RASD1 SNX18 SRC TEC TRIM14 TTC8 UBASH3B VPS26C YAP1 ZNF497
Entrez ID		112574	11099
HPRD ID		15407	04468
Ensembl ID		ENSG00000178996	ENSG00000070778
Uniprot IDs		Q96RF0	Q16825
PDB IDs			8GVL 8GVV 8GWH 8GXE 8Y8Y
Enriched GO Terms of Interacting Partners?		Regulation Of Pro-B Cell Differentiation Regulation Of Lymphoid Progenitor Cell Differentiation Mitophagy Autophagy Of Mitochondrion Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding SH3 Domain Binding Regulation Of T Cell Differentiation In Thymus B Cell Homeostasis Macroautophagy Regulation Of Hematopoietic Progenitor Cell Differentiation	Protein Phosphorylation Cardiac Muscle Tissue Regeneration Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Phosphorylation Protein Autophosphorylation Peptidyl-tyrosine Phosphorylation Centriolar Satellite Tissue Regeneration Intestinal Epithelial Cell Development Protein Kinase Activity U2-type Catalytic Step 1 Spliceosome Microtubule-based Process Columnar/cuboidal Epithelial Cell Development Interleukin-6-mediated Signaling Pathway Cytoskeleton Kinase Activity Establishment Of Planar Polarity Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein ERBB2 Signaling Pathway Mitotic Spindle Organization Spindle Assembly Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Polarized Epithelial Cell Differentiation Positive Regulation Of Protein Localization Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Cardiac Muscle Cell Proliferation
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