SNX2 and CENPQ

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SNX2	CENPQ
Description		sorting nexin 2	centromere protein Q
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Cytosol Endosome Membrane Membrane Lamellipodium Retromer Complex Retromer, Tubulation Complex Cytoplasmic Vesicle Early Endosome Membrane Protein-containing Complex Cell Projection	Chromosome, Centromeric Region Inner Kinetochore Nucleus Nucleoplasm Chromosome Cytosol Actin Cytoskeleton
	Molecular Function	Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Protein Binding Lipid Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Protein Heterodimerization Activity Transferrin Receptor Binding Leptin Receptor Binding	Protein Binding
	Biological Process	Intracellular Protein Transport Protein Transport Early Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Lamellipodium Morphogenesis	Chromosome Segregation Metaphase Chromosome Alignment Positive Regulation Of Protein Localization To Kinetochore
Pathways		Golgi Associated Vesicle Biogenesis	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy ( 26460308) Plateletcrit ( 32888494) Subcortical volume (MOSTest) ( 32665545)	Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		27 interacting genes: ACVR1B ACVR2B ARL6IP1 C1orf122 CENPQ CSNK2B DUSP10 EGFR FNBP1 INSR LAMC1 LEPR MET MTIF3 NFYC PAK6 PDGFRA PDGFRB PLIN3 PNKP SNX1 SNX4 SNX6 TMEM239 VAPA YIF1A ZNF202	12 interacting genes: AARD ABI2 ABI3 APP BRME1 CENPU EMILIN1 HDAC7 KDM1A PLK1 SIKE1 SNX2
Entrez ID		6643	55166
HPRD ID		09332	10788
Ensembl ID		ENSG00000205302	ENSG00000031691
Uniprot IDs		O60749	Q7L2Z9
PDB IDs			7PB8 7PKN 7QOO 7R5S 7R5V 7XHN 7XHO 7YWX 7YYH
Enriched GO Terms of Interacting Partners?		Receptor Complex Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Activin Receptor Signaling Pathway Kinase Activity Protein Kinase Activity Retina Vasculature Development In Camera-type Eye Protein Tyrosine Kinase Activity Cellular Response To Growth Factor Stimulus Phospholipase C Activator Activity Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Metanephric Glomerular Capillary Formation Response To Growth Factor Regulation Of Activin Receptor Signaling Pathway Activin Receptor Activity Vascular Endothelial Growth Factor Binding Retromer, Tubulation Complex Leptin Receptor Binding Glomerular Capillary Formation Protein Autophosphorylation Enzyme-linked Receptor Protein Signaling Pathway Activin Receptor Complex Vesicle-mediated Transport Regulation Of Histamine Secretion By Mast Cell Regulation Of Cell Migration Vasculature Development Regulation Of Cell Motility Activin Binding Cadherin Binding Platelet-derived Growth Factor Binding Transferrin Receptor Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity ATP Binding Regulation Of Locomotion Protein Phosphorylation Positive Regulation Of Cell Migration Positive Regulation Of Cell Communication Regulation Of Cell Communication Positive Regulation Of Cell Motility Positive Regulation Of Signaling Regulation Of Signaling Platelet-derived Growth Factor Receptor Binding Cardiac Myofibril Assembly Regulation Of Signal Transduction Anatomical Structure Morphogenesis Early Endosome Membrane Positive Regulation Of Locomotion Phosphorylation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Respiratory Burst Vascular Endothelial Growth Factor Signaling Pathway	Cell Projection Morphogenesis SCAR Complex Actin-based Cell Projection Identical Protein Binding Insulin Receptor Binding Regulation Of Postsynapse Organization Dendritic Spine Neuron Maturation Cell Junction Organization Lamellipodium Regulation Of Lamellipodium Assembly Dendritic Shaft Regulation Of Dendritic Spine Morphogenesis Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To CAMP Regulation Of Lamellipodium Organization Peptidyl-tyrosine Phosphorylation Regulation Of Plasma Membrane Bounded Cell Projection Organization Epigenetic Regulation Of Gene Expression Regulation Of Cell Projection Organization Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Synapse Organization Anatomical Structure Morphogenesis Endosome To Plasma Membrane Transport Vesicle Negative Regulation Of Signal Transduction Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Developmental Process Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To CAMP Negative Regulation Of Cellular Component Organization Phosphorylation Synaptonemal Complex Disassembly Protein Phosphorylation Nuclear Division Golgi Inheritance Chromosome Regulation Of Double-strand Break Repair Via Homologous Recombination Signaling Adaptor Activity
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