SLC12A2 and OXSR1

Number of citations of the paper that reports this interaction (PubMedID 16669787)
18

Data Source:
HPRD (in vitro)

		SLC12A2	OXSR1
Description		solute carrier family 12 member 2	oxidative stress responsive kinase 1
Image
GO Annotations	Cellular Component	Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Cytoplasmic Vesicle Membrane Cell Projection Membrane Cell Projection Neuron Projection Neuronal Cell Body Cell Body Cell Body Membrane Extracellular Exosome Cell Periphery Extracellular Vesicle	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Sodium:potassium:chloride Symporter Activity Ammonium Channel Activity Potassium Ion Transmembrane Transporter Activity Symporter Activity Chloride:monoatomic Cation Symporter Activity Protein Kinase Binding Transmembrane Transporter Activity Metal Ion Transmembrane Transporter Activity Protein-folding Chaperone Binding Hsp90 Protein Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Potassium Channel Inhibitor Activity Protein Kinase Binding Identical Protein Binding Transmembrane Transporter Binding Metal Ion Binding Ion Channel Regulator Activity Protein Serine Kinase Activity
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Chloride Transport Intracellular Sodium Ion Homeostasis Cell Volume Homeostasis Hyperosmotic Response Gamma-aminobutyric Acid Signaling Pathway T Cell Chemotaxis Intracellular Potassium Ion Homeostasis Transepithelial Chloride Transport Intracellular Chloride Ion Homeostasis Maintenance Of Blood-brain Barrier Sodium Ion Transmembrane Transport Cellular Response To Potassium Ion Positive Regulation Of Cell Volume Chloride Ion Homeostasis Potassium Ion Homeostasis Sodium Ion Homeostasis Transmembrane Transport Negative Regulation Of Vascular Wound Healing Transepithelial Ammonium Transport Ammonium Transmembrane Transport Inorganic Anion Import Across Plasma Membrane Inorganic Cation Import Across Plasma Membrane Sodium Ion Import Across Plasma Membrane Regulation Of Spontaneous Synaptic Transmission Transport Across Blood-brain Barrier Chloride Transmembrane Transport Positive Regulation Of Aspartate Secretion Regulation Of Matrix Metallopeptidase Secretion Potassium Ion Import Across Plasma Membrane Cellular Response To Chemokine	Protein Phosphorylation Cell Volume Homeostasis Response To Oxidative Stress Signal Transduction Osmosensory Signaling Pathway Response To Xenobiotic Stimulus Positive Regulation Of T Cell Chemotaxis Intracellular Signal Transduction Chemokine (C-C Motif) Ligand 21 Signaling Pathway Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway Protein Autophosphorylation Renal Sodium Ion Absorption Cellular Hyperosmotic Response Cellular Hypotonic Response Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport Cellular Response To Chemokine
Pathways		Cation-coupled Chloride cotransporters
Drugs		Torasemide Potassium chloride Bumetanide Quinethazone	Fostamatinib
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Beard thickness ( 26926045) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) HDL cholesterol levels ( 32203549) Height ( 25282103 31562340) Hip circumference adjusted for BMI ( 34021172) Ileal carcinoids ( 21139019) Immature fraction of reticulocytes ( 32888494) Pelvic organ prolapse ( 32184442) Red cell distribution width ( 28957414) Statin-induced myopathy ( 31220337)	Gut microbiota (bacterial taxa) ( 27723756) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		3 interacting genes: COMMD1 OXSR1 STK39	16 interacting genes: AKT1 APP BMPR1B GORASP1 OGT PAK1 RELL1 SLC12A1 SLC12A2 SLC12A6 SMURF1 STT3B TGFBR1 WNK1 WNK2 WNK4
Entrez ID		6558	9943
HPRD ID		06775	06809
Ensembl ID		ENSG00000064651	ENSG00000172939
Uniprot IDs		B7ZM24 P55011 Q53ZR1	O95747
PDB IDs		6PZT 7D10 7MXO 7N3N 7S1X 7S1Y 7S1Z 7SFL 7SMP 7ZGO 8STE 9C0E 9C0G 9C0H	2V3S 2VWI 3DAK 7OKW
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Monoatomic Ion Transport Negative Regulation Of Transmembrane Transport Ion Channel Regulator Activity Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway Cellular Hypotonic Response Potassium Channel Inhibitor Activity Negative Regulation Of Sodium Ion Transmembrane Transport Hypotonic Response Positive Regulation Of T Cell Chemotaxis Negative Regulation Of Sodium Ion Transport Cellular Response To Chemokine Regulation Of T Cell Chemotaxis Cellular Hyperosmotic Response Positive Regulation Of Lymphocyte Chemotaxis Regulation Of Monoatomic Cation Transmembrane Transport Renal Sodium Ion Absorption Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport Renal Sodium Ion Transport Regulation Of Lymphocyte Chemotaxis Hyperosmotic Response Regulation Of Metal Ion Transport Negative Regulation Of Potassium Ion Transport Positive Regulation Of T Cell Migration Cell Volume Homeostasis Regulation Of Monoatomic Ion Transport Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Transport Positive Regulation Of Lymphocyte Migration Renal Absorption Cellular Response To Osmotic Stress Regulation Of T Cell Migration Regulation Of Potassium Ion Transmembrane Transport Regulation Of Lymphocyte Migration Regulation Of Sodium Ion Transport Response To Osmotic Stress Chemokine-mediated Signaling Pathway Regulation Of Cell Size Regulation Of Potassium Ion Transport Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Chemotaxis Renal System Process Protein Autophosphorylation Positive Regulation Of Sodium Ion Import Across Plasma Membrane Positive Regulation Of Cholesterol Import Transmembrane Transporter Binding Positive Regulation Of Chemotaxis Regulation Of Mononuclear Cell Migration	Monoatomic Anion Homeostasis Chloride Ion Homeostasis Chemical Homeostasis Protein Serine/threonine Kinase Activity Cell Volume Homeostasis Potassium Ion Homeostasis Chloride:monoatomic Cation Symporter Activity Intracellular Chloride Ion Homeostasis Monoatomic Ion Homeostasis Protein Kinase Activity Potassium Ion Transmembrane Transport Potassium Ion Transport Membrane Regulation Of Sodium Ion Transport Transferase Activity Homeostatic Process Kinase Activity Regulation Of Cell Size Cellular Homeostasis Response To Stress Inorganic Ion Homeostasis Sodium:potassium:chloride Symporter Activity Chloride Transport Potassium Ion Transmembrane Transporter Activity Protein-containing Complex Monoatomic Cation Homeostasis Positive Regulation Of Signal Transduction Negative Regulation Of Multicellular Organismal Process Intracellular Chemical Homeostasis Protein Metabolic Process Sodium Ion Transmembrane Transport Regulation Of Developmental Growth Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Multicellular Organismal Process Transforming Growth Factor Beta Receptor Activity, Type I Inorganic Anion Transport Monoatomic Anion Transport Negative Regulation Of Pancreatic Juice Secretion Regulation Of Protein Localization Potassium Ion Import Across Plasma Membrane Positive Regulation Of Developmental Process Metal Ion Transport Regulation Of Developmental Process Regulation Of Protein Localization To Cell Periphery Protein Phosphorylation Inorganic Cation Transmembrane Transport Regulation Of Metal Ion Transport Regulation Of Spontaneous Synaptic Transmission SMAD Binding
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