SLC12A2

Description		solute carrier family 12 member 2
Image
GO Annotations	Cellular Component	Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Cytoplasmic Vesicle Membrane Cell Projection Membrane Cell Projection Neuron Projection Neuronal Cell Body Cell Body Cell Body Membrane Extracellular Exosome Cell Periphery Extracellular Vesicle
	Molecular Function	Protein Binding Sodium:potassium:chloride Symporter Activity Ammonium Channel Activity Potassium Ion Transmembrane Transporter Activity Symporter Activity Chloride:monoatomic Cation Symporter Activity Protein Kinase Binding Transmembrane Transporter Activity Metal Ion Transmembrane Transporter Activity Protein-folding Chaperone Binding Hsp90 Protein Binding
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Chloride Transport Intracellular Sodium Ion Homeostasis Cell Volume Homeostasis Hyperosmotic Response Gamma-aminobutyric Acid Signaling Pathway T Cell Chemotaxis Intracellular Potassium Ion Homeostasis Transepithelial Chloride Transport Intracellular Chloride Ion Homeostasis Maintenance Of Blood-brain Barrier Sodium Ion Transmembrane Transport Cellular Response To Potassium Ion Positive Regulation Of Cell Volume Chloride Ion Homeostasis Potassium Ion Homeostasis Sodium Ion Homeostasis Transmembrane Transport Negative Regulation Of Vascular Wound Healing Transepithelial Ammonium Transport Ammonium Transmembrane Transport Inorganic Anion Import Across Plasma Membrane Inorganic Cation Import Across Plasma Membrane Sodium Ion Import Across Plasma Membrane Regulation Of Spontaneous Synaptic Transmission Transport Across Blood-brain Barrier Chloride Transmembrane Transport Positive Regulation Of Aspartate Secretion Regulation Of Matrix Metallopeptidase Secretion Potassium Ion Import Across Plasma Membrane Cellular Response To Chemokine
Pathways		Cation-coupled Chloride cotransporters
Drugs		Torasemide Potassium chloride Bumetanide Quinethazone
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Beard thickness ( 26926045) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) HDL cholesterol levels ( 32203549) Height ( 25282103 31562340) Hip circumference adjusted for BMI ( 34021172) Ileal carcinoids ( 21139019) Immature fraction of reticulocytes ( 32888494) Pelvic organ prolapse ( 32184442) Red cell distribution width ( 28957414) Statin-induced myopathy ( 31220337)
Novel Interacting Genes		3 novel interacting genes: COMMD1 OXSR1 STK39
Interacting Genes		3 interacting genes: COMMD1 OXSR1 STK39
Entrez ID		6558
HPRD ID		06775
Ensembl ID		ENSG00000064651
Uniprot IDs		B7ZM24 P55011 Q53ZR1
PDB IDs		6PZT 7D10 7MXO 7N3N 7S1X 7S1Y 7S1Z 7SFL 7SMP 7ZGO 8STE 9C0E 9C0G 9C0H
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Monoatomic Ion Transport Negative Regulation Of Transmembrane Transport Ion Channel Regulator Activity Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway Cellular Hypotonic Response Potassium Channel Inhibitor Activity Negative Regulation Of Sodium Ion Transmembrane Transport Hypotonic Response Positive Regulation Of T Cell Chemotaxis Negative Regulation Of Sodium Ion Transport Cellular Response To Chemokine Regulation Of T Cell Chemotaxis Cellular Hyperosmotic Response Positive Regulation Of Lymphocyte Chemotaxis Regulation Of Monoatomic Cation Transmembrane Transport Renal Sodium Ion Absorption Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport Renal Sodium Ion Transport Regulation Of Lymphocyte Chemotaxis Hyperosmotic Response Regulation Of Metal Ion Transport Negative Regulation Of Potassium Ion Transport Positive Regulation Of T Cell Migration Cell Volume Homeostasis Regulation Of Monoatomic Ion Transport Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Transport Positive Regulation Of Lymphocyte Migration Renal Absorption Cellular Response To Osmotic Stress Regulation Of T Cell Migration Regulation Of Potassium Ion Transmembrane Transport Regulation Of Lymphocyte Migration Regulation Of Sodium Ion Transport Response To Osmotic Stress Chemokine-mediated Signaling Pathway Regulation Of Cell Size Regulation Of Potassium Ion Transport Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Chemotaxis Renal System Process Protein Autophosphorylation Positive Regulation Of Sodium Ion Import Across Plasma Membrane Positive Regulation Of Cholesterol Import Transmembrane Transporter Binding Positive Regulation Of Chemotaxis Regulation Of Mononuclear Cell Migration
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