SLC9A2 and SPTAN1

Number of citations of the paper that reports this interaction (PubMedID 30021884)
83

Data Source:
BioGRID (proximity labelling technology)
HPRD (in vitro)

		SLC9A2	SPTAN1
Description		solute carrier family 9 member A2	spectrin alpha, non-erythrocytic 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Apical Plasma Membrane	Extracellular Region Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Cortex Spectrin Microtubule Cytoskeleton Membrane Cell Junction Cortical Actin Cytoskeleton Specific Granule Lumen Cell Projection Extracellular Exosome Extracellular Vesicle Tertiary Granule Lumen
	Molecular Function	Antiporter Activity Sodium:proton Antiporter Activity Potassium:proton Antiporter Activity	Actin Binding Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Calmodulin Binding Cadherin Binding Metal Ion Binding Actin Filament Binding
	Biological Process	Monoatomic Ion Transport Monoatomic Cation Transport Sodium Ion Transport Regulation Of PH Intracellular Protein Localization Epithelial Cell Differentiation Regulation Of Intracellular PH Transmembrane Transport Potassium Ion Transmembrane Transport Sodium Ion Import Across Plasma Membrane Proton Transmembrane Transport	Actin Cytoskeleton Organization Actin Filament Capping
Pathways		Sodium/Proton exchangers	Caspase-mediated cleavage of cytoskeletal proteins Nephrin family interactions NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade Neutrophil degranulation COPI-mediated anterograde transport RHOU GTPase cycle RHOV GTPase cycle Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases			Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Delirium ( 29631748) Gut microbiota (bacterial taxa) ( 27723756) Night sleep phenotypes ( 27126917) Plateletcrit ( 32888494)	Axial length ( 24144296) Body mass index ( 26426971)
Interacting Genes		8 interacting genes: ABL1 CHP1 CHP2 PIK3R1 RASA1 SPTA1 SPTAN1 SRC	63 interacting genes: ABI1 ABL1 ACP1 ACTA1 ACTB AKIP1 ANK1 C5 CAPN1 CASP3 CASP7 CEP63 CNTRL CREBBP CTNNA1 DDX24 DES EPB41 EPB41L2 EPB42 ERCC4 EVL EXOC1 FANCA FANCC GAP43 GRIA2 GRIN1 GRIN2A GRIN2B GRIN2D ITSN1 KALRN KARS1 MAPK6 NEFL PCNT PDE4D PIN4 PLEC PLEKHA5 PRKCB PSMG1 PTEN PTOV1 SHANK1 SHANK3 SLC9A2 SOS1 SPTB SPTBN1 SPTBN4 SRC STAT1 SUMO2 SYN1 TAF1 TANC1 TES TRAF1 TSSC4 TTC3 ZNF333
Entrez ID		6549	6709
HPRD ID		02756	01684
Ensembl ID		ENSG00000115616	ENSG00000197694
Uniprot IDs		Q9UBY0	A0A0D9SF54 A0A0D9SFF6 A0A0D9SGF6 A0A384P5S9 A0A994J6W3 Q13813
PDB IDs			2FOT 3F31 3FB2 5FW9 5FWB 5FWC 6ZEH
Enriched GO Terms of Interacting Partners?		Regulation Of Actin Filament Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Regulation Of Cell-matrix Adhesion Regulation Of Actin Filament-based Process Regulation Of Dephosphorylation Regulation Of Protein-containing Complex Assembly Regulation Of Protein Localization To Nucleus Negative Regulation Of Cell-matrix Adhesion Phosphotyrosine Residue Binding Substrate Adhesion-dependent Cell Spreading Ephrin Receptor Signaling Pathway Regulation Of Cytoskeleton Organization Regulation Of Cell-substrate Adhesion Regulation Of Protein Import Into Nucleus Regulation Of Organelle Organization Negative Regulation Of Cell-substrate Adhesion Positive Regulation Of Dephosphorylation Regulation Of Intracellular Transport Regulation Of Cell-substrate Junction Organization Negative Regulation Of Cell Adhesion Spectrin Regulation Of Phosphatase Activity Positive Regulation Of Protein Localization To Nucleus Regulation Of Cell Adhesion Regulation Of Biological Quality Actin Cytoskeleton Organization Regulation Of Nucleocytoplasmic Transport Actin Filament-based Process Regulation Of Actin Filament Polymerization Plasma Membrane Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein Localization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Intracellular Protein Transport Cell Activation Involved In Immune Response Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Cell-substrate Adhesion Leukocyte Activation Involved In Immune Response Supramolecular Fiber Organization Negative Regulation Of Supramolecular Fiber Organization Negative Regulation Of Cytoskeleton Organization Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Cellular Localization Regulation Of Intracellular Signal Transduction Regulation Of Catalytic Activity Ephrin Receptor Binding	Postsynaptic Density Structural Constituent Of Cytoskeleton Cytoskeleton Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Spectrin Cytoplasm Ligand-gated Ion Channel Signaling Pathway Modulation Of Excitatory Postsynaptic Potential Glutamate Receptor Signaling Pathway Cytosol Cytoskeletal Protein Binding NMDA Glutamate Receptor Activity Spectrin-associated Cytoskeleton NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Excitatory Chemical Synaptic Transmission Regulation Of System Process Glutamatergic Synapse Ligand-gated Monoatomic Ion Channel Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Synapse Neuromuscular Process Modulation Of Chemical Synaptic Transmission Regulation Of Nervous System Process Cytoskeleton Organization Neuron Projection Regulation Of Biological Quality Ankyrin Binding Learning Or Memory Cell Junction Plasma Membrane Dendritic Spine Cell Projection Organization Associative Learning Glutamate Binding Postsynaptic Membrane Cognition Regulation Of Neuronal Synaptic Plasticity Plasma Membrane Bounded Cell Projection Organization Spectrin Binding Cortical Cytoskeleton SH3 Domain Binding Regulation Of Membrane Potential Cell Surface Receptor Signaling Pathway Dendritic Spine Organization Actin Cytoskeleton Organization Cell Junction Organization Cellular Component Assembly Dendrite
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