SLC9A2 and RASA1

Number of citations of the paper that reports this interaction (PubMedID 10187839)
0

Data Source:
HPRD (in vitro)

		SLC9A2	RASA1
Description		solute carrier family 9 member A2	RAS p21 protein activator 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Apical Plasma Membrane	Ruffle Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Antiporter Activity Sodium:proton Antiporter Activity Potassium:proton Antiporter Activity	Phosphotyrosine Residue Binding GTPase Activity GTPase Activator Activity Signaling Receptor Binding Protein Binding Potassium Channel Inhibitor Activity Enzyme Binding GTPase Binding
	Biological Process	Monoatomic Ion Transport Monoatomic Cation Transport Sodium Ion Transport Regulation Of PH Intracellular Protein Localization Epithelial Cell Differentiation Regulation Of Intracellular PH Transmembrane Transport Potassium Ion Transmembrane Transport Sodium Ion Import Across Plasma Membrane Proton Transmembrane Transport	Mitotic Cytokinesis Angiogenesis Vasculogenesis Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Cell Adhesion Signal Transduction Regulation Of Cell Shape Regulation Of Actin Filament Polymerization Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Ephrin Receptor Signaling Pathway Blood Vessel Morphogenesis System Development Regulation Of RNA Metabolic Process Regulation Of Intracellular Signal Transduction
Pathways		Sodium/Proton exchangers	Downstream signal transduction EPHB-mediated forward signaling EPHB-mediated forward signaling VEGFR2 mediated cell proliferation Regulation of RAS by GAPs PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Drugs
Diseases			RASA1-related disorders, including: Parkes-Weber slndrome; Capillary malformation-arteriovenous malformation (CM-AVM); Arteriovenous fistula (AVF)
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Delirium ( 29631748) Gut microbiota (bacterial taxa) ( 27723756) Night sleep phenotypes ( 27126917) Plateletcrit ( 32888494)	Chronotype ( 30696823) Macular thickness ( 30535121) Major depressive disorder ( 23377640) Openness ( 21173776) Prostate cancer aggressiveness ( 25939597) Type 2 diabetes ( 30297969)
Interacting Genes		8 interacting genes: ABL1 CHP1 CHP2 PIK3R1 RASA1 SPTA1 SPTAN1 SRC	95 interacting genes: ABL1 AFAP1L2 ALK ANXA6 APC APP AR ARHGAP1 ARHGAP5 AURKA AURKB BBS10 BCL10 BCR BIRC5 BMPR1A BUB1 CASP3 CASP7 CAV2 CD5 CDKN2A CSF1R CSK DCC DLC1 DNAJA3 DOK1 DOK2 DOK4 EGFR EIF1 EPHA2 EPHB2 EPHB3 ERBB2 ERBB3 ERBB4 EZH2 FES FGFR1 G3BP1 GAB1 GMCL1 GRB2 HCK HRAS HSPD1 HTT IGF1R INSR KDR KHDRBS1 KIT LCK LYN MAGI1 MAP4K4 MET MLH3 NCK1 NTRK1 OLIG1 PAG1 PDE6D PDGFRB PIK3R1 PMS2 PTK2B PTPRC PTPRJ PXN RAB5A RACK1 RAP1A RB1 SERPINA4 SHC1 SLC9A2 SMAD2 SOCS3 SPSB1 SRC STAU1 STK11 SYK SYN1 TRMT2A WWP1 WWP2 XRCC6 YES1 ZAP70 ZNF366 ZNF579
Entrez ID		6549	5921
HPRD ID		02756	00745
Ensembl ID		ENSG00000115616	ENSG00000145715
Uniprot IDs		Q9UBY0	P20936 Q59GK3
PDB IDs			1WER 1WQ1 2GQI 2GSB 2J05 2J06 2M51 4FSS 6PXB 6PXC 6WAX 6WAY 8BOS 8DGQ 9BZ4
Enriched GO Terms of Interacting Partners?		Regulation Of Actin Filament Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Regulation Of Cell-matrix Adhesion Regulation Of Actin Filament-based Process Regulation Of Dephosphorylation Regulation Of Protein-containing Complex Assembly Regulation Of Protein Localization To Nucleus Negative Regulation Of Cell-matrix Adhesion Phosphotyrosine Residue Binding Substrate Adhesion-dependent Cell Spreading Ephrin Receptor Signaling Pathway Regulation Of Cytoskeleton Organization Regulation Of Cell-substrate Adhesion Regulation Of Protein Import Into Nucleus Regulation Of Organelle Organization Negative Regulation Of Cell-substrate Adhesion Positive Regulation Of Dephosphorylation Regulation Of Intracellular Transport Regulation Of Cell-substrate Junction Organization Negative Regulation Of Cell Adhesion Spectrin Regulation Of Phosphatase Activity Positive Regulation Of Protein Localization To Nucleus Regulation Of Cell Adhesion Regulation Of Biological Quality Actin Cytoskeleton Organization Regulation Of Nucleocytoplasmic Transport Actin Filament-based Process Regulation Of Actin Filament Polymerization Plasma Membrane Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein Localization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Intracellular Protein Transport Cell Activation Involved In Immune Response Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Cell-substrate Adhesion Leukocyte Activation Involved In Immune Response Supramolecular Fiber Organization Negative Regulation Of Supramolecular Fiber Organization Negative Regulation Of Cytoskeleton Organization Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Cellular Localization Regulation Of Intracellular Signal Transduction Regulation Of Catalytic Activity Ephrin Receptor Binding	Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Protein Kinase Activity Cell Surface Receptor Signaling Pathway Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cellular Component Organization Regulation Of Signal Transduction Regulation Of MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Signal Transduction ATP Binding Protein Autophosphorylation Protein Phosphorylation Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Regulation Of Cellular Component Organization Phosphorylation Regulation Of Apoptotic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Intracellular Signal Transduction Nucleotide Binding Regulation Of Cell Population Proliferation Regulation Of Cell Adhesion SH2 Domain Binding Positive Regulation Of Cell Migration Protein Modification Process Positive Regulation Of Cell Motility Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Locomotion Developmental Process Positive Regulation Of Immune System Process Regulation Of Cell Motility Negative Regulation Of Programmed Cell Death Positive Regulation Of Cellular Component Biogenesis Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Cell Migration Receptor Complex Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Cell Population Proliferation Regulation Of Locomotion
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