SIM2 and MAST3

		SIM2	MAST3
Description		SIM bHLH transcription factor 2	microtubule associated serine/threonine kinase 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nuclear Body	Cytoplasm Microtubule Cytoskeleton
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Heterodimerization Activity Protein Dimerization Activity	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Embryonic Pattern Specification Cell Differentiation Lung Development Negative Regulation Of DNA-templated Transcription System Development	Cytoskeleton Organization Intracellular Signal Transduction
Pathways
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Asthma and hay fever ( 24388013) Cerebellum cortex volume ( 31530798) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Night sleep phenotypes ( 27126917) Red blood cell count ( 27863252)	A body shape index ( 34021172) Adult body size ( 32376654) Alanine aminotransferase levels ( 33547301) Body fat mass ( 28552196) Eosinophil percentage of white cells ( 32888494) Glycine levels ( 30837465) Liver enzyme levels (alanine transaminase) ( 33972514) Mental health study participation (completed survey) ( 31263887) Number of sexual partners ( 30643258) Percent liver fat ( 34128465) Red cell distribution width ( 32888494) Urate levels ( 31578528) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Walking pace ( 33128006)
Interacting Genes		11 interacting genes: ADD3 ARNT CRYAA EPS15L1 MAGED1 MAST3 PAX6 PPP5C PREX1 PRKN PTGES3	6 interacting genes: CNTNAP4 FOXP2 GDF15 MYCBP2 PTEN SIM2
Entrez ID		6493	23031
HPRD ID		02935	19403
Ensembl ID		ENSG00000159263	ENSG00000099308
Uniprot IDs		Q14190	A0A8I5KST9 A0A8V8TLL8 A0A8V8TMW0 O60307
PDB IDs			1V9V 3KHF
Enriched GO Terms of Interacting Partners?		Cytoplasm Response To Oxidative Stress Protein-containing Complex Embryonic Camera-type Eye Morphogenesis Embryonic Eye Morphogenesis Protein Serine/threonine Kinase Inhibitor Activity Cellular Response To Oxidative Stress Positive Regulation Of ATP Metabolic Process Protein Folding Chaperone Complex Hsp90 Protein Binding Lens Development In Camera-type Eye Protein Stabilization Hsp70 Protein Binding Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Organization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization System Process Cytosol Regulation Of Epithelial Cell Proliferation Nuclear Aryl Hydrocarbon Receptor Complex Regulation Of ATP Metabolic Process Cellular Response To Chemical Stress Regulation Of Purine Nucleotide Metabolic Process Eye Morphogenesis Sensory Organ Morphogenesis Response To Hydrogen Peroxide Regulation Of Protein Stability Camera-type Eye Development Protein-folding Chaperone Binding Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Positive Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Glucokinase Activity Regulation Protein Catabolic Process At Presynapse Negative Regulation Of Intralumenal Vesicle Formation Mitochondrion To Lysosome Vesicle-mediated Transport Mitochondrion-derived Vesicle F-box Domain Binding Positive Regulation Of Protein Linear Polyubiquitination Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Hydrogen Sulfide Negative Regulation Of Spontaneous Neurotransmitter Secretion Heat Shock Protein Binding Response To Curcumin Protein Polymerization Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Habenula Development Pallium Development Response To Arachidonate	Central Nervous System Neuron Axonogenesis Regulation Of Growth Negative Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Developmental Growth Regulation Of Developmental Growth Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Lung Development Response To Metformin Putamen Development Caudate Nucleus Development Central Nervous System Myelin Maintenance Circadian Rhythm Rhythmic Synaptic Transmission Regulation Of Grooming Behavior Locomotor Rhythm Regulation Of Cell Junction Assembly Cell Projection Morphogenesis Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Cellular Response To Electrical Stimulus Learning Or Memory Negative Regulation Of Growth Regulation Of Locomotion Ubiquitin Ligase Activator Activity Spindle Assembly Involved In Female Meiosis Neuron Projection Morphogenesis Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Synaptic Vesicle Clustering Postsynaptic Specialization Assembly Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Neuron-neuron Synaptic Transmission Phosphatidylinositol Phosphate Phosphatase Activity Negative Regulation Of Cell Size Presynaptic Membrane Organization Schmidt-Lanterman Incisure Anaphase-promoting Complex Binding Postsynaptic Density Assembly Rhythmic Process Forebrain Morphogenesis Negative Regulation Of Excitatory Postsynaptic Potential Axonogenesis Presynaptic Membrane Assembly Nervous System Process GDF15-GFRAL Signaling Pathway Regulation Of Growth Hormone Receptor Signaling Pathway Negative Regulation Of Appetite Negative Regulation Of Growth Hormone Receptor Signaling Pathway
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