SIM2 and ADD3

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		SIM2	ADD3
Description		SIM bHLH transcription factor 2	adducin 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nuclear Body	Condensed Nuclear Chromosome Cytoplasm Cytosol Cytoskeleton Plasma Membrane Brush Border Cell-cell Junction Cell Cortex Postsynaptic Density Membrane
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Heterodimerization Activity Protein Dimerization Activity	Actin Binding Protein Kinase C Binding Structural Constituent Of Cytoskeleton Calmodulin Binding Actin Filament Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Embryonic Pattern Specification Cell Differentiation Lung Development Negative Regulation Of DNA-templated Transcription System Development	Cytoskeleton Organization Response To Xenobiotic Stimulus Positive Regulation Of Vasoconstriction Barbed-end Actin Filament Capping Positive Regulation Of Cytoskeleton Organization
Pathways			Miscellaneous transport and binding events RHOD GTPase cycle RHOF GTPase cycle
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Asthma and hay fever ( 24388013) Cerebellum cortex volume ( 31530798) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Night sleep phenotypes ( 27126917) Red blood cell count ( 27863252)	Biliary atresia ( 20460270) Bipolar disorder ( 28072414 31043756 33263727 34002096) Cutaneous melanoma or hair colour ( 32341527) Metabolite levels ( 23823483) Neutrophil count ( 29403010) Refractive error ( 32231278) White blood cell count ( 29403010)
Interacting Genes		11 interacting genes: ADD3 ARNT CRYAA EPS15L1 MAGED1 MAST3 PAX6 PPP5C PREX1 PRKN PTGES3	14 interacting genes: AGTR1 ATXN1 CWF19L1 GNG13 HSPB1 OPRM1 PENK PRKCA RPL4 SIM2 TRIM8 TUBGCP4 UBE2I ZNF76
Entrez ID		6493	120
HPRD ID		02935	03339
Ensembl ID		ENSG00000159263	ENSG00000148700
Uniprot IDs		Q14190	Q53FL4 Q59EK1 Q5VU08 Q9UEY8
PDB IDs
Enriched GO Terms of Interacting Partners?		Cytoplasm Response To Oxidative Stress Protein-containing Complex Embryonic Camera-type Eye Morphogenesis Embryonic Eye Morphogenesis Protein Serine/threonine Kinase Inhibitor Activity Cellular Response To Oxidative Stress Positive Regulation Of ATP Metabolic Process Protein Folding Chaperone Complex Hsp90 Protein Binding Lens Development In Camera-type Eye Protein Stabilization Hsp70 Protein Binding Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Organization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization System Process Cytosol Regulation Of Epithelial Cell Proliferation Nuclear Aryl Hydrocarbon Receptor Complex Regulation Of ATP Metabolic Process Cellular Response To Chemical Stress Regulation Of Purine Nucleotide Metabolic Process Eye Morphogenesis Sensory Organ Morphogenesis Response To Hydrogen Peroxide Regulation Of Protein Stability Camera-type Eye Development Protein-folding Chaperone Binding Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Positive Regulation Of Retrograde Transport, Endosome To Golgi Negative Regulation Of Glucokinase Activity Regulation Protein Catabolic Process At Presynapse Negative Regulation Of Intralumenal Vesicle Formation Mitochondrion To Lysosome Vesicle-mediated Transport Mitochondrion-derived Vesicle F-box Domain Binding Positive Regulation Of Protein Linear Polyubiquitination Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Hydrogen Sulfide Negative Regulation Of Spontaneous Neurotransmitter Secretion Heat Shock Protein Binding Response To Curcumin Protein Polymerization Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Habenula Development Pallium Development Response To Arachidonate	G Protein-coupled Opioid Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway G-protein Beta-subunit Binding Nuclear Body Angiotensin Type I Receptor Activity System Process Negative Regulation Of Protein Kinase C Signaling Morphine Receptor Activity Nervous System Process Sensory Perception Of Pain Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Synaptic Vesicle Lumen Nuclear Membrane Organization SUMO Conjugating Enzyme Activity RNA Lariat Debranching Enzyme Activator Activity
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