BMP1 and CLIP2

		BMP1	CLIP2
Description		bone morphogenetic protein 1	CAP-Gly domain containing linker protein 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Vesicle	Nucleus Cytoplasm Cytoskeleton Microtubule Microtubule Associated Complex Cell Cortex Microtubule Cytoskeleton Microtubule Plus-end
	Molecular Function	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Cytokine Activity Calcium Ion Binding Protein Binding Growth Factor Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding	Microtubule Binding Microtubule Plus-end Binding
	Biological Process	Skeletal System Development Cartilage Condensation Ossification Proteolysis Signal Transduction Dorsal/ventral Pattern Formation Protein Processing Cell Differentiation Collagen Fibril Organization Cartilage Development Positive Regulation Of Cartilage Development	Cytoplasmic Microtubule Organization
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Collagen biosynthesis and modifying enzymes Anchoring fibril formation Crosslinking of collagen fibrils
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Hypertriglyceridemia ( 23505323) Myocardial infarction ( 33532862) Waist-to-hip ratio adjusted for BMI ( 28552196)	Age at suicide ( 31476763) Autism spectrum disorders (social interaction) ( 32624584) SAPHO syndrome ( 33816493)
Interacting Genes		18 interacting genes: ADRA1A CHRD CLIP2 COL1A1 COL5A1 COL5A2 COL7A1 CST7 DST GEM HSPG2 LAMA3 LAMB3 LAMC2 PTPRZ1 TP53 TWSG1 YLPM1	5 interacting genes: BMP1 CLASP2 DYNLL1 ITSN1 MAX
Entrez ID		649	7461
HPRD ID		00209	09140
Ensembl ID		ENSG00000168487	ENSG00000106665
Uniprot IDs		P13497	A0A140VJG6 A7E2F7 Q9UDT6
PDB IDs		3EDG 3EDH 6BSL 6BSM 6BTN 6BTO 6BTP 6BTQ	2CP2 2CP3
Enriched GO Terms of Interacting Partners?		Basement Membrane Extracellular Matrix Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Fibrillar Collagen Trimer Extracellular Region Tissue Development Collagen Trimer Collagen Type V Trimer Negative Regulation Of Endodermal Cell Differentiation Laminin-5 Complex Endodermal Cell Differentiation Collagen Type XI Trimer Epidermis Development Hemidesmosome Assembly Integrin Binding Skin Development Hemidesmosome Collagen Fibril Organization Regulation Of Developmental Process Platelet-derived Growth Factor Binding Collagen Biosynthetic Process Cell Adhesion Protease Binding Response To Xenobiotic Stimulus Microtubule Plus-end Binding Endoplasmic Reticulum Lumen Developmental Process Microtubule Plus-end Negative Regulation Of Developmental Process Animal Organ Development Anatomical Structure Morphogenesis System Development Extracellular Space Negative Regulation Of Cell Differentiation Heparin Binding Regulation Of Cell Differentiation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell-substrate Junction Assembly Cell Cortex Structural Molecule Activity Cell-substrate Junction Organization Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Regulation Of Cell Population Proliferation Cellular Response To Vitamin E Skeletal System Development Integrin Biosynthetic Process Collagen Type VII Trimer Regulation Of Myelination	Positive Regulation Of Secretion Positive Regulation Of Secretion By Cell Myc-Max Complex Mad-Max Complex Positive Regulation Of Peptide Hormone Secretion Clathrin-dependent Synaptic Vesicle Endocytosis Positive Regulation Of Peptide Secretion Regulation Of Secretion Regulation Of Secretion By Cell Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Positive Regulation Of Basement Membrane Assembly Involved In Embryonic Body Morphogenesis Cortical Microtubule Plus-end Positive Regulation Of Hormone Secretion Deoxyribonuclease Inhibitor Activity Mitotic Spindle Regulation Of DNA Strand Resection Involved In Replication Fork Processing Nitric-oxide Synthase Inhibitor Activity Kinetochore Cortical Microtubule Cytoskeleton Positive Regulation Of Transport Positive Regulation Of Caveolin-mediated Endocytosis Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Regulation Of Peptide Hormone Secretion Basal Cortex Extracellular Structure Organization Extracellular Matrix Organization Regulation Of Hormone Secretion Regulation Of Caveolin-mediated Endocytosis Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Nitric-oxide Synthase Regulator Activity Presynaptic Cytoskeleton Organization Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Basement Membrane Organization Postsynaptic Endocytic Zone Postsynaptic Actin Cytoskeleton Positive Regulation Of Growth Hormone Secretion Positive Regulation Of Extracellular Matrix Disassembly Dystroglycan Binding Positive Regulation Of Extracellular Matrix Assembly Negative Regulation Of DNA-templated DNA Replication Cell Projection Regulation Of Growth Hormone Secretion Intraciliary Retrograde Transport Microtubule Positive Regulation Of Developmental Process Regulation Of Modification Of Postsynaptic Structure Negative Regulation Of Nitric Oxide Biosynthetic Process DNA Strand Resection Involved In Replication Fork Processing Regulation Of Gastrulation Exit From Mitosis
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