MTARC1 and EPHB6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MTARC1	EPHB6
Description		mitochondrial amidoxime reducing component 1	EPH receptor B6
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Membrane Nitric-oxide Synthase Complex	Extracellular Region Cytosol Plasma Membrane Membrane Dendrite
	Molecular Function	Catalytic Activity Protein Binding Nitrate Reductase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Other Nitrogenous Compounds As Donors Molybdenum Ion Binding Pyridoxal Phosphate Binding Molybdopterin Cofactor Binding Metal Ion Binding Nitrite Reductase (NO-forming) Activity Nitrite Reductase Activity	Nucleotide Binding Protein Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding Signaling Receptor Activity
	Biological Process	Nitric Oxide Biosynthetic Process Nitrate Metabolic Process Detoxification Of Nitrogen Compound Cellular Detoxification Of Nitrogen Compound	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Ephrin Receptor Signaling Pathway
Pathways		Phase I - Functionalization of compounds	EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells
Drugs			Fostamatinib
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874)	Alcoholic chronic pancreatitis ( 28754779) Blood protein levels ( 30072576) Cancer ( 29299148)
Interacting Genes		7 interacting genes: C1orf115 DISP1 EPHB6 HHIPL2 IARS2 NAA11 SLC30A10	28 interacting genes: AFDN ASB12 CBL CRK CRKL DDIT4L DUSP18 DUSP19 EFNB2 EPHB1 ERBB2 GRB2 HDHD2 INCA1 MSX2 MTARC1 NIF3L1 NOTCH2NLA POU6F2 PRMT5 REL SAT1 STYX TCF4 TEKT5 TRIB3 TRIM39 VPS26C
Entrez ID		64757	2051
HPRD ID		08653	04133
Ensembl ID		ENSG00000186205	ENSG00000106123
Uniprot IDs		Q5VT66	A0A0G2JNH7 F8WCM8 O15197
PDB IDs		6FW2	7K7J
Enriched GO Terms of Interacting Partners?		Detoxification Of Zinc Ion Manganese Ion Export Across Plasma Membrane Calcium:manganese Antiporter Activity Isoleucine-tRNA Ligase Activity Isoleucyl-tRNA Aminoacylation Protein-N-terminal-alanine Acetyltransferase Activity Protein-N-terminal-glutamate Acetyltransferase Activity Patched Ligand Maturation Protein N-terminal-serine Acetyltransferase Activity Manganese Ion Transmembrane Transporter Activity Intracellular Manganese Ion Homeostasis Manganese Ion Homeostasis Protein-N-terminal Amino-acid Acetyltransferase Activity NatA Complex Zinc Ion Import Into Organelle Manganese Ion Transmembrane Transport Manganese Ion Transport Aminoacyl-tRNA Metabolism Involved In Translational Fidelity Aminoacyl-tRNA Deacylase Activity 9+0 Non-motile Cilium Regulation Of Response To Drug N-terminal Protein Amino Acid Acetylation Diaphragm Development Molecular Carrier Activity Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Cellular Response To Angiotensin Intracellular Copper Ion Homeostasis Monoatomic Cation Transmembrane Transporter Activity Regulation Of Translational Fidelity Protein Maturation Copper Ion Homeostasis Skeletal Muscle Organ Development	Ephrin Receptor Binding Regulation Of MAPK Cascade Phosphotyrosine Residue Binding Regulation Of Signal Transduction Receptor Tyrosine Kinase Binding Helper T Cell Diapedesis Cerebellar Neuron Development Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Enzyme-linked Receptor Protein Signaling Pathway Diapedesis Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Kinase Inhibitor Activity Cellular Response To Growth Factor Stimulus Ephrin Receptor Signaling Pathway Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cell Adhesion Postsynaptic Specialization Assembly Response To Growth Factor Positive Regulation Of Receptor Clustering Reelin-mediated Signaling Pathway Positive Regulation Of Small GTPase Mediated Signal Transduction Neuromuscular Junction Cerebral Cortex Development Regulation Of Receptor Clustering Positive Regulation Of Rac Protein Signal Transduction Schwann Cell Development Protein Tyrosine/serine/threonine Phosphatase Activity Establishment Of Cell Polarity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Postsynaptic Specialization Organization SH3 Domain Binding Neuron Projection Development Regulation Of Protein Serine/threonine Kinase Activity Cytoplasm Signal Transduction Protein Binding Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Cell Adhesion Regulation Of Rac Protein Signal Transduction T Cell Migration Identical Protein Binding Guanyl-nucleotide Exchange Factor Adaptor Activity Spermidine Binding
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