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SHC1 and TPR
Number of citations of the paper that reports this interaction (PubMedID
11896612
)
0
Data Source:
HPRD
(in vitro)
SHC1
TPR
Description
SHC adaptor protein 1
translocated promoter region, nuclear basket protein
Image
GO Annotations
Cellular Component
Cytoplasm
Mitochondrion
Mitochondrial Matrix
Cytosol
Plasma Membrane
Focal Adhesion
Anchoring Junction
Shc-EGFR Complex
Chromosome, Centromeric Region
Kinetochore
Nucleus
Nuclear Envelope
Nuclear Pore
Nucleoplasm
Chromosome
Cytoplasm
Spindle
Cytoskeleton
Cytoplasmic Dynein Complex
Membrane
Nuclear Membrane
Nuclear Periphery
Nuclear Inclusion Body
Nuclear Pore Nuclear Basket
Mitotic Spindle
Molecular Function
Phosphotyrosine Residue Binding
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Epidermal Growth Factor Receptor Binding
Insulin Receptor Binding
Insulin-like Growth Factor Receptor Binding
Neurotrophin TRKA Receptor Binding
Protein Binding
Phospholipid Binding
Receptor Tyrosine Kinase Binding
Ephrin Receptor Binding
Epidermal Growth Factor Binding
Chromatin Binding
RNA Binding
MRNA Binding
Protein Binding
Tubulin Binding
Structural Constituent Of Nuclear Pore
Heat Shock Protein Binding
Protein Homodimerization Activity
Protein-membrane Adaptor Activity
Mitogen-activated Protein Kinase Binding
Dynein Complex Binding
Biological Process
Angiogenesis
Epidermal Growth Factor Receptor Signaling Pathway
Heart Development
Positive Regulation Of Cell Population Proliferation
Insulin Receptor Signaling Pathway
Negative Regulation Of Angiogenesis
Actin Cytoskeleton Organization
Intracellular Signal Transduction
Regulation Of Cell Population Proliferation
Defense Response To Bacterium
Negative Regulation Of Apoptotic Process
Positive Regulation Of MAPK Cascade
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Insulin-like Growth Factor Receptor Signaling Pathway
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Cell Proliferation In Bone Marrow
Regulation Of Superoxide Metabolic Process
Cell-cell Adhesion
Negative Regulation Of Transcription By RNA Polymerase II
RNA Import Into Nucleus
RNA Export From Nucleus
MRNA Export From Nucleus
Protein Import Into Nucleus
Protein Export From Nucleus
Intracellular Protein Transport
Nucleocytoplasmic Transport
Nuclear Pore Organization
Mitotic Spindle Assembly Checkpoint Signaling
Regulation Of MRNA Export From Nucleus
Regulation Of Mitotic Sister Chromatid Separation
Protein Transport
Positive Regulation Of Heterochromatin Formation
Regulation Of Protein Stability
MRNA Export From Nucleus In Response To Heat Stress
Regulation Of Protein Localization
Cellular Response To Heat
Cellular Response To Interferon-alpha
Regulation Of Protein Import Into Nucleus
Positive Regulation Of Protein Import Into Nucleus
Nuclear Matrix Organization
Negative Regulation Of Translational Initiation
Positive Regulation Of Nucleocytoplasmic Transport
Regulation Of Protein Export From Nucleus
Positive Regulation Of Protein Export From Nucleus
Negative Regulation Of RNA Export From Nucleus
MRNA Transport
Nuclear Export
Nuclear Pore Complex Assembly
Cell Division
Response To Epidermal Growth Factor
Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Positive Regulation Of Intracellular Protein Transport
Regulation Of Mitotic Spindle Assembly
Pathways
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
SHC1 events in ERBB2 signaling
SHC1 events in ERBB2 signaling
SHC1 events in ERBB4 signaling
Signalling to RAS
Signalling to RAS
SHC1 events in EGFR signaling
Tie2 Signaling
Integrin signaling
XBP1(S) activates chaperone genes
Interleukin-3, Interleukin-5 and GM-CSF signaling
Constitutive Signaling by EGFRvIII
RAF/MAP kinase cascade
Signal attenuation
Insulin receptor signalling cascade
Insulin receptor signalling cascade
RET signaling
Interleukin-15 signaling
Interleukin-15 signaling
Interleukin-2 signaling
Erythropoietin activates RAS
Erythropoietin activates RAS
Interleukin receptor SHC signaling
Constitutive Signaling by Overexpressed ERBB2
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Signaling by CSF3 (G-CSF)
Signaling by CSF3 (G-CSF)
Signaling by CSF1 (M-CSF) in myeloid cells
ISG15 antiviral mechanism
Transport of the SLBP independent Mature mRNA
Transport of the SLBP Dependant Mature mRNA
Transport of Mature mRNA Derived from an Intronless Transcript
Transport of Mature mRNA derived from an Intron-Containing Transcript
Rev-mediated nuclear export of HIV RNA
Transport of Ribonucleoproteins into the Host Nucleus
NS1 Mediated Effects on Host Pathways
Viral Messenger RNA Synthesis
NEP/NS2 Interacts with the Cellular Export Machinery
Regulation of Glucokinase by Glucokinase Regulatory Protein
Nuclear import of Rev protein
Vpr-mediated nuclear import of PICs
IPs transport between nucleus and cytosol
IP3 and IP4 transport between cytosol and nucleus
IP6 and IP7 transport between cytosol and nucleus
snRNP Assembly
SUMOylation of DNA damage response and repair proteins
SUMOylation of ubiquitinylation proteins
Nuclear Pore Complex (NPC) Disassembly
Regulation of HSF1-mediated heat shock response
SUMOylation of SUMOylation proteins
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA replication proteins
Transcriptional regulation by small RNAs
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
tRNA processing in the nucleus
HCMV Early Events
HCMV Late Events
SARS-CoV-2 activates/modulates innate and adaptive immune responses
Signaling by ALK fusions and activated point mutants
Drugs
Diseases
Thyroid cancer
GWAS
Bipolar disorder (
31043756
)
Body fat distribution (leg fat ratio) (
30664634
)
Body fat distribution (trunk fat ratio) (
30664634
)
Eosinophil count (
29403010
)
Hemoglobin levels (
32327693
)
Inflammatory bowel disease (
27569725
)
Prostate cancer (
23535732
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Interacting Genes
147 interacting genes:
ALK
AP2A1
AP2A2
APP
AR
AXL
BCL3
BCR
BUB1
C11orf58
CALCOCO2
CALD1
CBL
CBLB
CBLC
CD22
CD247
CD3E
CD81
CDH5
CEACAM1
CFTR
CRK
CRKL
CSF1R
CSF2RB
CSF3R
CSK
DAG1
DDR1
DDR2
DNAH7
DOK1
DUSP23
EGFR
EPHA2
EPOR
EPS8
ERBB2
ERBB3
ERBB4
ESR1
FAM118B
FBXW7
FCGR2A
FCGR3A
FGFR1
FGFR2
FLT1
FLT3
FLT4
FYN
GAB1
GAB2
GEMIN7
GH1
GHR
GRAP
GRAP2
GRB2
GRB7
HMOX2
IGF1R
IL2
IL2RB
IL2RG
IL4R
IL6ST
ILK
INPP5D
INPPL1
INSR
IRS1
IRS2
ITGB3
ITGB4
JAK2
KDR
KIT
KRT18
LCK
LCP2
LRP1
LTK
LYN
MAP4K1
MAPK1
MAPK14
MAPK6
MAPK8
MAPKAPK2
MET
MME
MPL
MRPL44
MST1R
NGFR
NPM1
NTRK1
NTRK2
NTRK3
NUDT21
OSGEP
PAG1
PAK1
PDGFRB
PIK3C2B
PIK3R1
PIK3R2
PLCG1
PLCG2
PLPP3
PLSCR1
PPP2R5A
PRKCA
PRKCD
PRKRA
PTK2
PTK2B
PTPN11
PTPN12
PTPN2
PTPN6
RAPGEF1
RASA1
RB1
RET
SH2B2
SHCBP1
SMAD4
SOS1
SOS2
SP1
SRC
STAT5A
STAT5B
SUV39H2
SYK
TEC
TEK
TH
TPR
TRIM15
UBASH3B
VAV1
VAV3
ZAP70
20 interacting genes:
APC
CDK1
ERCC6
HTT
IFI16
MAD1L1
MAP3K4
MAPK1
MDM2
MECOM
NUP153
NUP98
PRKACA
SHC1
SUMO2
TNFSF4
USP7
WEE2-AS1
YWHAQ
ZC3HC1
Entrez ID
6464
7175
HPRD ID
02780
08927
Ensembl ID
ENSG00000160691
ENSG00000047410
Uniprot IDs
P29353
P12270
PDB IDs
1MIL
1N3H
1OY2
1QG1
1SHC
1TCE
2L1C
4JMH
4XWX
5CZI
6DM4
5TO5
5TO6
5TO7
5TVB
Enriched GO Terms of Interacting Partners
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Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Protein Tyrosine Kinase Activity
Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of MAPK Cascade
Transmembrane Receptor Protein Tyrosine Kinase Activity
Regulation Of Signal Transduction
Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Protein Kinase Activity
Receptor Complex
Regulation Of Cell Population Proliferation
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Signaling
Regulation Of Cell Communication
Kinase Activity
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Multicellular Organismal Process
Plasma Membrane
Positive Regulation Of MAPK Cascade
Protein Phosphorylation
Positive Regulation Of Multicellular Organismal Process
Regulation Of Immune System Process
Phosphorylation
Phosphotyrosine Residue Binding
Intracellular Signal Transduction
Regulation Of Developmental Process
Protein Autophosphorylation
Immune System Process
Regulation Of Immune Response
Regulation Of Programmed Cell Death
Regulation Of Cell Adhesion
Intracellular Signaling Cassette
Response To Growth Factor
Cell Activation
Cytokine-mediated Signaling Pathway
Positive Regulation Of Immune System Process
Cell Migration
Regulation Of Apoptotic Process
Positive Regulation Of Cell Migration
Regulation Of Cell Activation
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Developmental Process
Positive Regulation Of Cell Motility
Nuclear Pore Nuclear Basket
Intracellular Signal Transduction
Positive Regulation Of Metabolic Process
Regulation Of Chromosome Organization
Regulation Of Intracellular Transport
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Chromosome Organization
Nucleoplasm
Regulation Of Nucleocytoplasmic Transport
Cellular Response To Nutrient Levels
Regulation Of DNA Metabolic Process
Positive Regulation Of DNA Metabolic Process
Regulation Of Primary Metabolic Process
DNA Damage Response
Regulation Of Cellular Localization
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Metabolic Process
Positive Regulation Of Mitotic Sister Chromatid Segregation
Positive Regulation Of Nucleocytoplasmic Transport
Regulation Of Protein Catabolic Process
Positive Regulation Of Biosynthetic Process
RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
Nuclear Pore Complex Assembly
Protein Localization To Organelle
Negative Regulation Of Metabolic Process
Transcription-coupled Nucleotide-excision Repair
P53 Binding
Regulation Of Proteasomal Protein Catabolic Process
Nuclear Inclusion Body
Regulation Of Gene Expression
Regulation Of Macromolecule Metabolic Process
Regulation Of RNA Metabolic Process
Nuclear Envelope
Insulin Receptor Signaling Pathway
Nucleus
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Metaphase Plate Congression
Response To UV-C
Nuclear Pore Organization
Negative Regulation Of Cell Cycle Phase Transition
Regulation Of Cell Cycle Phase Transition
Protein Metabolic Process
Regulation Of Cell Cycle
MAPK Cascade
Nucleus Organization
Positive Regulation Of Intracellular Protein Transport
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