VPS16 and RILP

Number of citations of the paper that reports this interaction (PubMedID 25445562)
46

Data Source:
BioGRID (pull down)

		VPS16	RILP
Description		VPS16 core subunit of CORVET and HOPS complexes	Rab interacting lysosomal protein
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GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Autophagosome Endosome Membrane Membrane Clathrin-coated Vesicle Axon HOPS Complex Cytoplasmic Vesicle Late Endosome Membrane CORVET Complex Neuronal Cell Body Recycling Endosome Presynapse Vesicle Tethering Complex	Cytoplasm Lysosome Lysosomal Membrane Endosome Late Endosome Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Late Endosome Membrane Protein-containing Complex Ciliary Basal Body
	Molecular Function	Actin Binding Protein Binding Actin Filament Binding	Protein Binding Small GTPase Binding Protein Dimerization Activity Dynein Light Intermediate Chain Binding
	Biological Process	Intracellular Protein Transport Autophagy Vacuole Organization Endosome To Lysosome Transport Protein Transport Endosomal Transport Endosomal Vesicle Fusion Regulation Of SNARE Complex Assembly Vacuole Fusion, Non-autophagic Autophagosome Maturation	Endosome To Lysosome Transport Protein Transport Endosome Transport Via Multivesicular Body Sorting Pathway Negative Regulation Of Protein Catabolic Process Early Endosome To Late Endosome Transport Positive Regulation Of Protein Catabolic Process Cilium Assembly Intralumenal Vesicle Formation
Pathways		SARS-CoV-2 modulates autophagy	MHC class II antigen presentation
Drugs
Diseases
GWAS		Lymphocyte percentage of white cells ( 32888494) Metabolite levels ( 23823483)
Interacting Genes		18 interacting genes: AKTIP EXOC8 FBXO7 GNG13 HOOK1 HOOK2 HOOK3 MON1B RAB7A RILP STX1A STX7 UBC UVRAG VPS11 VPS18 VPS33A ZNF417	12 interacting genes: KPNA2 LDB2 RAB34 RAB7A RCHY1 SNF8 VPS11 VPS16 VPS18 VPS36 VPS39 VPS41
Entrez ID		64601	83547
HPRD ID		12259	09706
Ensembl ID		ENSG00000215305	ENSG00000167705
Uniprot IDs		Q9H269	Q96NA2
PDB IDs		4BX9	1YHN
Enriched GO Terms of Interacting Partners?		Endosome To Lysosome Transport HOPS Complex Vesicle Organization Vacuolar Transport Lysosomal Transport Endosome Organization Early Endosome To Late Endosome Transport Vesicle-mediated Transport Establishment Of Protein Localization Protein Transport Late Endosome FHF Complex Protein Localization To Perinuclear Region Of Cytoplasm Cellular Localization Intracellular Transport Organelle Localization Membrane Docking Vacuole Organization Vesicle Fusion Organelle Membrane Fusion Intracellular Protein Localization Establishment Of Localization In Cell Organelle Fusion Vesicle Docking Lysosome Organization Membrane Fusion Organelle Localization By Membrane Tethering Dynein Light Intermediate Chain Binding CORVET Complex Organelle Organization Vesicle Docking Involved In Exocytosis Membrane Organization Endosomal Transport Lysosome Autophagy Late Endosome Membrane Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Intracellular Protein Transport Autophagosome Lysosomal Membrane Endosome Endosome Membrane Cytoplasmic Vesicle Early Endosome Syntaxin Binding Chloride Channel Inhibitor Activity SNARE Binding Cytoplasmic Microtubule Organization Protein Modification By Small Protein Conjugation	Vesicle Organization Late Endosome Membrane Vacuolar Transport Organelle Membrane Fusion Vesicle Fusion Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion HOPS Complex Endosome To Lysosome Transport Organelle Fusion Autophagy Late Endosome Membrane Fusion Intracellular Protein Transport Membrane Organization Protein Transport Lysosomal Transport Endosome Membrane Establishment Of Protein Localization Cellular Localization Vesicle-mediated Transport Endosome Intracellular Transport Intracellular Protein Localization Lysosome CORVET Complex AP-3 Adaptor Complex Establishment Of Localization In Cell Establishment Of Protein Localization To Vacuole Lysosomal Membrane Clathrin-coated Vesicle Organelle Organization Endosome Organization Protein Localization To Vacuole Catabolic Process Lysosomal HOPS Complex Endosomal Transport ESCRT II Complex Vesicle-mediated Transport To The Plasma Membrane Establishment Of Protein Localization To Organelle Vesicle Tethering Complex Macroautophagy Vacuole Organization Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein Catabolic Process Cytoplasmic Vesicle Endocytic Recycling Autophagosome Phagosome Maturation Membrane Docking
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