VPS16 and AKTIP

Number of citations of the paper that reports this interaction (PubMedID 18799622)
36

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		VPS16	AKTIP
Description		VPS16 core subunit of CORVET and HOPS complexes	AKT interacting protein
Image
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Autophagosome Endosome Membrane Membrane Clathrin-coated Vesicle Axon HOPS Complex Cytoplasmic Vesicle Late Endosome Membrane CORVET Complex Neuronal Cell Body Recycling Endosome Presynapse Vesicle Tethering Complex	Nucleus Cytoplasm Plasma Membrane Membrane HOPS Complex FHF Complex
	Molecular Function	Actin Binding Protein Binding Actin Filament Binding	Protein Binding Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Intracellular Protein Transport Autophagy Vacuole Organization Endosome To Lysosome Transport Protein Transport Endosomal Transport Endosomal Vesicle Fusion Regulation Of SNARE Complex Assembly Vacuole Fusion, Non-autophagic Autophagosome Maturation	Positive Regulation Of Protein Phosphorylation Postreplication Repair Apoptotic Process Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Positive Regulation Of Protein Binding Early Endosome To Late Endosome Transport Protein K63-linked Ubiquitination Protein Localization To Perinuclear Region Of Cytoplasm
Pathways		SARS-CoV-2 modulates autophagy
Drugs
Diseases
GWAS		Lymphocyte percentage of white cells ( 32888494) Metabolite levels ( 23823483)	Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Depressive symptoms (SSRI exposure interaction) ( 25649181) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Hip circumference adjusted for BMI ( 25673412 34021172) Serum alkaline phosphatase levels ( 33547301) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		18 interacting genes: AKTIP EXOC8 FBXO7 GNG13 HOOK1 HOOK2 HOOK3 MON1B RAB7A RILP STX1A STX7 UBC UVRAG VPS11 VPS18 VPS33A ZNF417	35 interacting genes: ACTN2 AKT1 ASS1 CEP126 CTBP2 DMXL2 DZIP3 EXOC7 FHIP1B GTF3C1 HOOK1 HOOK2 HOOK3 IMMT IPO7 LMNA MAP3K7 MARCHF5 MATR3 NEB PDE4DIP PDPK1 POLA2 RASGRF2 RPA1 TRIM23 TRIM41 TWNK UPF2 UTP14A VPS16 VPS18 VPS28 VPS41 ZNRF2
Entrez ID		64601	64400
HPRD ID		12259	07467
Ensembl ID		ENSG00000215305	ENSG00000166971
Uniprot IDs		Q9H269	Q9H8T0
PDB IDs		4BX9	8QAT
Enriched GO Terms of Interacting Partners?		Endosome To Lysosome Transport HOPS Complex Vesicle Organization Vacuolar Transport Lysosomal Transport Endosome Organization Early Endosome To Late Endosome Transport Vesicle-mediated Transport Establishment Of Protein Localization Protein Transport Late Endosome FHF Complex Protein Localization To Perinuclear Region Of Cytoplasm Cellular Localization Intracellular Transport Organelle Localization Membrane Docking Vacuole Organization Vesicle Fusion Organelle Membrane Fusion Intracellular Protein Localization Establishment Of Localization In Cell Organelle Fusion Vesicle Docking Lysosome Organization Membrane Fusion Organelle Localization By Membrane Tethering Dynein Light Intermediate Chain Binding CORVET Complex Organelle Organization Vesicle Docking Involved In Exocytosis Membrane Organization Endosomal Transport Lysosome Autophagy Late Endosome Membrane Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Intracellular Protein Transport Autophagosome Lysosomal Membrane Endosome Endosome Membrane Cytoplasmic Vesicle Early Endosome Syntaxin Binding Chloride Channel Inhibitor Activity SNARE Binding Cytoplasmic Microtubule Organization Protein Modification By Small Protein Conjugation	HOPS Complex Endosome To Lysosome Transport FHF Complex Intracellular Protein Localization Protein Transport Vacuolar Transport Protein Localization To Perinuclear Region Of Cytoplasm Intracellular Transport Lysosomal Transport Establishment Of Protein Localization Cellular Localization Endosome Organization Intracellular Protein Transport Establishment Of Localization In Cell Early Endosome To Late Endosome Transport Vesicle Organization Lysosome Organization Cytoplasmic Microtubule Organization Vacuole Organization Regulation Of SNARE Complex Assembly Endosomal Vesicle Fusion Protein Localization To Organelle Identical Protein Binding Cellular Response To Laminar Fluid Shear Stress Organelle Organization Response To Laminar Fluid Shear Stress Vesicle-mediated Transport Endosomal Transport Endosome Membrane Dynein Light Intermediate Chain Binding CGAS/STING Signaling Pathway Membrane Organization Cellular Response To Fluid Shear Stress Establishment Of Protein Localization To Organelle Ubiquitin Protein Ligase Activity CORVET Complex Response To Fluid Shear Stress Protein Import Into Nucleus Positive Regulation Of CGAS/STING Signaling Pathway Import Into Nucleus Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Nuclear Transport Nucleocytoplasmic Transport Protein Ubiquitination AP-3 Adaptor Complex Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Regulation Of Innate Immune Response Anoikis Microtubule Cytoskeleton Organization Late Endosome Membrane
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?