HHIP and SHH

Number of citations of the paper that reports this interaction (PubMedID 10050855)
0

Data Source:
HPRD (in vivo)

		HHIP	SHH
Description		hedgehog interacting protein	sonic hedgehog signaling molecule
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane Cell Surface Membrane Ciliary Membrane	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Cell Surface Membrane Extracellular Matrix Membrane Raft
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding Hedgehog Family Protein Binding	Endopeptidase Activity Patched Binding Calcium Ion Binding Protein Binding Glycosaminoglycan Binding Peptidase Activity Zinc Ion Binding Morphogen Activity Transferase Activity Hydrolase Activity Laminin-1 Binding Metal Ion Binding Cholesterol-protein Transferase Activity
	Biological Process	Signal Transduction Neuroblast Proliferation Animal Organ Morphogenesis Dorsal/ventral Pattern Formation Negative Regulation Of Signal Transduction Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Smoothened Signaling Pathway Skeletal System Morphogenesis Epithelial Tube Branching Involved In Lung Morphogenesis	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Branching Involved In Blood Vessel Morphogenesis Vasculogenesis Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Cell Fate Specification Neural Crest Cell Migration Kidney Development Hair Follicle Development Vasculature Development Heart Looping Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Osteoblast Development Lymphoid Progenitor Cell Differentiation Determination Of Left/right Asymmetry In Lateral Mesoderm Regulation Of DNA-templated Transcription Proteolysis Protein Import Into Nucleus Endocytosis Smoothened Signaling Pathway Cell-cell Signaling Determination Of Left/right Symmetry Pattern Specification Process Ectoderm Development Neuroblast Proliferation Axon Guidance Central Nervous System Development Ventral Midline Development Hindgut Morphogenesis Heart Development Skeletal Muscle Tissue Development Blood Coagulation Androgen Metabolic Process Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Embryonic Pattern Specification Tissue Development Polarity Specification Of Anterior/posterior Axis Anterior/posterior Pattern Specification Dorsal/ventral Pattern Formation Mesenchymal Cell Proliferation Gene Expression Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Oligodendrocyte Development Striated Muscle Tissue Development Skeletal Muscle Cell Proliferation Positive Regulation Of Skeletal Muscle Cell Proliferation Myotube Differentiation Cell Migration Intein-mediated Protein Splicing Protein Autoprocessing Spinal Cord Dorsal/ventral Patterning Spinal Cord Motor Neuron Differentiation Thalamus Development Forebrain Regionalization Dorsal/ventral Neural Tube Patterning Cell Proliferation In External Granule Layer Cerebellar Granule Cell Precursor Proliferation Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation Telencephalon Regionalization Regulation Of Proteolysis Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Neuron Differentiation Respiratory Tube Development Lung Development Embryonic Limb Morphogenesis Negative Regulation Of Cell Migration Male Genitalia Development Prostate Gland Development Thyroid Gland Development Forebrain Development Midbrain Development Hindbrain Development Pancreas Development Hair Follicle Morphogenesis Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process T Cell Differentiation In Thymus Negative Regulation Of T Cell Differentiation In Thymus Positive Regulation Of T Cell Differentiation In Thymus Positive Regulation Of Immature T Cell Proliferation In Thymus Negative Regulation Of Transcription Elongation By RNA Polymerase II Protein Localization To Nucleus Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Tube Development Trunk Neural Crest Cell Migration T Cell Proliferation Regulation Of Cell Population Proliferation Negative Regulation Of T Cell Proliferation Negative Regulation Of Protein Catabolic Process Positive Regulation Of Protein Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Odontogenesis Regulation Of Odontogenesis Embryonic Digit Morphogenesis Camera-type Eye Development Negative Regulation Of Apoptotic Process CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Skin Development Positive Thymic T Cell Selection Negative Thymic T Cell Selection Intermediate Filament Organization Cell Fate Commitment Myoblast Differentiation Negative Regulation Of Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Alpha-beta T Cell Differentiation Cell Development Animal Organ Development Thymus Development Digestive Tract Morphogenesis Embryonic Digestive Tract Morphogenesis Embryonic Organ Development Developmental Growth Embryonic Morphogenesis Embryonic Foregut Morphogenesis Positive Regulation Of Skeletal Muscle Tissue Development Animal Organ Formation Anatomical Structure Formation Involved In Morphogenesis Neuron Fate Commitment Embryonic Skeletal System Development Astrocyte Differentiation Oligodendrocyte Differentiation Positive Regulation Of Astrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Smooth Muscle Tissue Development Branching Morphogenesis Of An Epithelial Tube Inner Ear Development Formation Of Anatomical Boundary Stem Cell Development Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Regulation Of Developmental Process Striated Muscle Cell Differentiation Positive Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Cell Division Bergmann Glial Cell Differentiation Roof Of Mouth Development Canonical Wnt Signaling Pathway Limb Development Limb Bud Formation Regulation Of Glial Cell Proliferation Lung Morphogenesis Lung Epithelium Development Trachea Development Trachea Morphogenesis Epithelial Tube Branching Involved In Lung Morphogenesis Branching Involved In Prostate Gland Morphogenesis Branching Involved In Salivary Gland Morphogenesis Bud Outgrowth Involved In Lung Branching Right Lung Development Left Lung Development Lung Lobe Morphogenesis Lung-associated Mesenchyme Development Primary Prostatic Bud Elongation Prostate Epithelial Cord Elongation Salivary Gland Cavitation Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Epithelial-mesenchymal Cell Signaling Regulation Of Prostatic Bud Formation Epithelial-mesenchymal Signaling Involved In Prostate Gland Development Epithelial Cell Proliferation Involved In Prostate Gland Development Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Regulation Of Mesenchymal Cell Proliferation Involved In Prostate Gland Development Mesenchymal Smoothened Signaling Pathway Involved In Prostate Gland Development Artery Development Mesenchymal Cell Proliferation Involved In Lung Development Somite Development Positive Regulation Of Sclerotome Development Cellular Response To Lithium Ion Dopaminergic Neuron Differentiation Stem Cell Proliferation Regulation Of Stem Cell Proliferation Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Metanephric Collecting Duct Development Negative Regulation Of Canonical Wnt Signaling Pathway Establishment Of Epithelial Cell Polarity Negative Regulation Of Cholesterol Efflux Mesenchymal Cell Apoptotic Process Apoptotic Signaling Pathway Self Proteolysis Skeletal Muscle Fiber Differentiation Regulation Of Nodal Signaling Pathway Regulation Of Protein Localization To Nucleus Negative Regulation Of Dopaminergic Neuron Differentiation Tracheoesophageal Septum Formation Negative Regulation Of Ureter Smooth Muscle Cell Differentiation Positive Regulation Of Ureter Smooth Muscle Cell Differentiation Negative Regulation Of Kidney Smooth Muscle Cell Differentiation Positive Regulation Of Kidney Smooth Muscle Cell Differentiation Positive Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Negative Regulation Of Mesenchymal Cell Apoptotic Process
Pathways		Ligand-receptor interactions	Class B/2 (Secretin family receptors) Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Release of Hh-Np from the secreting cell Release of Hh-Np from the secreting cell Ligand-receptor interactions Ligand-receptor interactions Hedgehog 'on' state Activation of SMO HHAT G278V doesn't palmitoylate Hh-Np Formation of lateral plate mesoderm Formation of axial mesoderm Developmental Lineage of Multipotent Pancreatic Progenitor Cells
Drugs
Diseases			Solitary median maxillary central incisor syndrome Anophthalmia and microphthalmia (A/M) Holoprosencephaly (HPE) Basal cell carcinoma
GWAS		A body shape index ( 34021172) Adolescent idiopathic scoliosis ( 30395268) Appendicular lean mass ( 33097823) Birth weight ( 27680694 31043758) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 25673413) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease ( 28166215 30804561 25101718 22080838 20173748 19300482) Chronic obstructive pulmonary disease (moderate to severe) ( 24621683) Chronic obstructive pulmonary disease (severe) ( 24621683) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Cortical surface area (MOSTest) ( 32665545) Daytime sleep phenotypes ( 27126917) Diverticular disease ( 30177863) Emphysema distribution in smoking ( 27669027) Emphysema imaging phenotypes ( 26030696) Fasting insulin ( 34059833) Femoral neck bone mineral density ( 30172743) Femoral neck size ( 31053729) Haemorrhoidal disease ( 33888516) Heel bone mineral density ( 30598549) Height ( 32902719 31562340 34270706 28552196 18391951 18391950 18391952 19343178 20397748 20881960 23563607 25282103 25429064) Hip bone size ( 31053729) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 34021172 25673412 28552196) Hip index ( 34021172) Infant length ( 25281659) Kidney volume ( 34128465) Local histogram emphysema pattern ( 25006744) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 28166213 31453325) Lung function (FEV1/FVC) variance ( 31453325) Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Malaria ( 31844061) Offspring birth weight ( 31043758) Pre bronchodilator FEV1/FVC ratio ( 26634245) Pre bronchodilator FEV1/FVC ratio in never-smokers ( 27612410) Pulmonary function ( 19300500 20010834 20010835) Pulmonary function (smoking interaction) ( 23284291) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28448500 34021172 25673412) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for body mass index ( 28430825)	Corneal astigmatism ( 23322567) Creatinine levels ( 29403010) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 30604766 31015462 31152163 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Macular thickness ( 30535121) Platelet aggregation ( 20526338 29185836)
Interacting Genes		3 interacting genes: DHH IHH SHH	5 interacting genes: ADCYAP1 GAS1 HHIP PTCH1 PTCH2
Entrez ID		64399	6469
HPRD ID		06937	02838
Ensembl ID		ENSG00000164161	ENSG00000164690
Uniprot IDs		Q96QV1	Q15465
PDB IDs		2WFT 2WFX 2WG3 2WG4 3HO3 3HO4 3HO5 7PGK 7PGL 7PGM 7PGN	3HO5 3M1N 3MXW 6DMY 6E1H 6N7G 6N7H 6N7K 6OEV 6PJV 6RMG 6RVD 7E2I 7MHZ 7RHQ 7URF
Enriched GO Terms of Interacting Partners?		Cholesterol-protein Transferase Activity Patched Binding Self Proteolysis Protein Autoprocessing Positive Regulation Of Smoothened Signaling Pathway Intein-mediated Protein Splicing Smoothened Signaling Pathway Regulation Of Smoothened Signaling Pathway Cell Fate Specification Positive Regulation Of T Cell Differentiation In Thymus Negative Regulation Of T Cell Differentiation In Thymus Protein Processing Regulation Of Immature T Cell Proliferation In Thymus Somite Development Embryonic Digestive Tract Morphogenesis Smooth Muscle Tissue Development Regulation Of T Cell Differentiation In Thymus Protein Maturation Pancreas Development Positive Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of Alpha-beta T Cell Differentiation Branching Involved In Blood Vessel Morphogenesis Regulation Of Mesenchymal Cell Proliferation Neuron Fate Commitment Peptidase Activity Negative Regulation Of Alpha-beta T Cell Activation Negative Regulation Of T Cell Differentiation Embryonic Skeletal System Development Embryonic Digit Morphogenesis Positive Regulation Of Alpha-beta T Cell Differentiation Vasculature Development Embryonic Pattern Specification Negative Regulation Of Lymphocyte Differentiation Heart Looping Cell-cell Signaling Calcium Ion Binding Embryonic Heart Tube Morphogenesis Signaling Golgi Membrane Negative Regulation Of T Cell Proliferation Cell Communication Positive Regulation Of Alpha-beta T Cell Activation Camera-type Eye Development Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Embryonic Organ Morphogenesis Eye Development Epithelial Tube Morphogenesis Negative Regulation Of Eye Pigmentation	Hedgehog Family Protein Binding Regulation Of Smoothened Signaling Pathway Negative Regulation Of Smoothened Signaling Pathway Hedgehog Receptor Activity Epidermal Cell Fate Specification Smoothened Binding Positive Regulation Of Epidermal Cell Differentiation Positive Regulation Of Epidermis Development Cell Fate Determination Ciliary Membrane Positive Regulation Of Epithelial Cell Differentiation Regulation Of Epidermal Cell Differentiation Dorsal/ventral Pattern Formation Regulation Of Epidermis Development Regulation Of Signal Transduction Cell Fate Specification Pituitary Adenylate Cyclase Activating Polypeptide Activity Neural Plate Axis Specification Regulation Of Cell Communication Regulation Of Signaling Type 2 Vasoactive Intestinal Polypeptide Receptor Binding Type 1 Vasoactive Intestinal Polypeptide Receptor Binding Response To Chlorate Branching Morphogenesis Of An Epithelial Tube Epidermis Development Morphogenesis Of A Branching Epithelium Regulation Of Epithelial Cell Differentiation Morphogenesis Of A Branching Structure Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Growth Hormone Secretion Regulation Of Cell Cycle Developmental Process Patched Binding Neural Tube Formation Cell Proliferation Involved In Metanephros Development Mammary Gland Duct Morphogenesis Metanephric Collecting Duct Development Neural Tube Patterning Dendritic Growth Cone Regionalization Tube Morphogenesis Cell Proliferation Involved In Kidney Development Peptide Hormone Receptor Binding Regulation Of ER To Golgi Vesicle-mediated Transport Regulation Of Growth Hormone Secretion Activation Of Adenylate Cyclase Activity Negative Regulation Of Multicellular Organism Growth Morphogenesis Of An Epithelium Collecting Duct Development Dorsal/ventral Neural Tube Patterning
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