HHIP

Description		hedgehog interacting protein
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane Cell Surface Membrane Ciliary Membrane
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding Hedgehog Family Protein Binding
	Biological Process	Signal Transduction Neuroblast Proliferation Animal Organ Morphogenesis Dorsal/ventral Pattern Formation Negative Regulation Of Signal Transduction Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Smoothened Signaling Pathway Skeletal System Morphogenesis Epithelial Tube Branching Involved In Lung Morphogenesis
Pathways		Ligand-receptor interactions
Drugs
Diseases
GWAS		A body shape index ( 34021172) Adolescent idiopathic scoliosis ( 30395268) Appendicular lean mass ( 33097823) Birth weight ( 27680694 31043758) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 25673413) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease ( 28166215 30804561 25101718 22080838 20173748 19300482) Chronic obstructive pulmonary disease (moderate to severe) ( 24621683) Chronic obstructive pulmonary disease (severe) ( 24621683) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Cortical surface area (MOSTest) ( 32665545) Daytime sleep phenotypes ( 27126917) Diverticular disease ( 30177863) Emphysema distribution in smoking ( 27669027) Emphysema imaging phenotypes ( 26030696) Fasting insulin ( 34059833) Femoral neck bone mineral density ( 30172743) Femoral neck size ( 31053729) Haemorrhoidal disease ( 33888516) Heel bone mineral density ( 30598549) Height ( 32902719 31562340 34270706 28552196 18391951 18391950 18391952 19343178 20397748 20881960 23563607 25282103 25429064) Hip bone size ( 31053729) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 34021172 25673412 28552196) Hip index ( 34021172) Infant length ( 25281659) Kidney volume ( 34128465) Local histogram emphysema pattern ( 25006744) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 28166213 31453325) Lung function (FEV1/FVC) variance ( 31453325) Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Malaria ( 31844061) Offspring birth weight ( 31043758) Pre bronchodilator FEV1/FVC ratio ( 26634245) Pre bronchodilator FEV1/FVC ratio in never-smokers ( 27612410) Pulmonary function ( 19300500 20010834 20010835) Pulmonary function (smoking interaction) ( 23284291) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28448500 34021172 25673412) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for body mass index ( 28430825)
Novel Interacting Genes		3 novel interacting genes: DHH IHH SHH
Interacting Genes		3 interacting genes: DHH IHH SHH
Entrez ID		64399
HPRD ID		06937
Ensembl ID		ENSG00000164161
Uniprot IDs		Q96QV1
PDB IDs		2WFT 2WFX 2WG3 2WG4 3HO3 3HO4 3HO5 7PGK 7PGL 7PGM 7PGN
Enriched GO Terms of Interacting Partners?		Cholesterol-protein Transferase Activity Patched Binding Self Proteolysis Protein Autoprocessing Positive Regulation Of Smoothened Signaling Pathway Intein-mediated Protein Splicing Smoothened Signaling Pathway Regulation Of Smoothened Signaling Pathway Cell Fate Specification Positive Regulation Of T Cell Differentiation In Thymus Negative Regulation Of T Cell Differentiation In Thymus Protein Processing Regulation Of Immature T Cell Proliferation In Thymus Somite Development Embryonic Digestive Tract Morphogenesis Smooth Muscle Tissue Development Regulation Of T Cell Differentiation In Thymus Protein Maturation Pancreas Development Positive Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of Alpha-beta T Cell Differentiation Branching Involved In Blood Vessel Morphogenesis Regulation Of Mesenchymal Cell Proliferation Neuron Fate Commitment Peptidase Activity Negative Regulation Of Alpha-beta T Cell Activation Negative Regulation Of T Cell Differentiation Embryonic Skeletal System Development Embryonic Digit Morphogenesis Positive Regulation Of Alpha-beta T Cell Differentiation Vasculature Development Embryonic Pattern Specification Negative Regulation Of Lymphocyte Differentiation Heart Looping Cell-cell Signaling Calcium Ion Binding Embryonic Heart Tube Morphogenesis Signaling Golgi Membrane Negative Regulation Of T Cell Proliferation Cell Communication Positive Regulation Of Alpha-beta T Cell Activation Camera-type Eye Development Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Embryonic Organ Morphogenesis Eye Development Epithelial Tube Morphogenesis Negative Regulation Of Eye Pigmentation
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