PALS1 and SRGAP2B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PALS1	SRGAP2B
Description		protein associated with LIN7 1, MAGUK p55 family member	SLIT-ROBO Rho GTPase activating protein 2B
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Plasma Membrane Adherens Junction Bicellular Tight Junction Endomembrane System Membrane Apical Plasma Membrane Axon Protein-containing Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Myelin Sheath Adaxonal Region Cell Projection Perikaryon Lateral Loop Schmidt-Lanterman Incisure Apical Junction Complex Apical Part Of Cell Extracellular Exosome Anchoring Junction	Dendritic Spine Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Protein Domain Specific Binding Identical Protein Binding	GTPase Activator Activity
	Biological Process	Morphogenesis Of An Epithelial Sheet Plasma Membrane Organization Intracellular Protein Localization Gene Expression Establishment Or Maintenance Of Polarity Of Embryonic Epithelium Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Central Nervous System Neuron Development Cerebral Cortex Development Peripheral Nervous System Myelin Maintenance Myelin Assembly Protein Localization To Myelin Sheath Abaxonal Region Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Generation Of Neurons Protein Localization To Plasma Membrane	Nervous System Development Negative Regulation Of Cell Migration Regulation Of Synapse Assembly
Pathways		Tight junction interactions SARS-CoV-1 targets PDZ proteins in cell-cell junction SARS-CoV-2 targets PDZ proteins in cell-cell junction SARS-CoV-2 targets PDZ proteins in cell-cell junction
Drugs
Diseases
GWAS
Interacting Genes		15 interacting genes: ARF6 CRB3 DLGAP4 FTCD GPRASP3 LIN7A MPP4 NEK9 NUMB PARD6B PATJ SNTG2 SOCS4 SRGAP2B TRAF2	7 interacting genes: FAM161B PALS1 SCML2 SPG21 USP20 WASHC3 ZNF655
Entrez ID		64398	647135
HPRD ID		09508
Ensembl ID		ENSG00000072415	ENSG00000196369
Uniprot IDs		Q8N3R9	A0A286YEY3 P0DMP2
PDB IDs		1Y76 3UIT 4UU5 4UU6 4WSI 7M4R 7NTJ 7NTK 7QCS
Enriched GO Terms of Interacting Partners?		Apical Part Of Cell Regulation Of Cell Junction Assembly Regulation Of Synapse Organization Bicellular Tight Junction Regulation Of Synapse Assembly Establishment Or Maintenance Of Cell Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Thioesterase Binding Cell Junction Organization Regulation Of Cellular Component Organization Apical Junction Complex Anchoring Junction Cell Cortex Cell-cell Junction Organization Tight Junction Cell Division Cell Junction Positive Regulation Of Cellular Component Biogenesis Erythrocyte Apoptotic Process TORC2 Complex Disassembly Glutamate Formimidoyltransferase Activity Formimidoyltetrahydrofolate Cyclodeaminase Activity Extracellular Exosome Regulation Of Dendritic Spine Development Glutamatergic Synapse Plasma Membrane TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding L-histidine Catabolic Process To Glutamate And Formate L-histidine Catabolic Process To Glutamate And Formamide Signaling Adaptor Activity Protein Localization To Cleavage Furrow Neuroblast Division In Subventricular Zone L27 Domain Binding Subapical Complex
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