PALS1 and PATJ

Number of citations of the paper that reports this interaction (PubMedID 11927608)
44

Data Source:
HPRD (in vivo)

		PALS1	PATJ
Description		protein associated with LIN7 1, MAGUK p55 family member	PATJ crumbs cell polarity complex component
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Plasma Membrane Adherens Junction Bicellular Tight Junction Endomembrane System Membrane Apical Plasma Membrane Axon Protein-containing Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Myelin Sheath Adaxonal Region Cell Projection Perikaryon Lateral Loop Schmidt-Lanterman Incisure Apical Junction Complex Apical Part Of Cell Extracellular Exosome Anchoring Junction	Cytoplasm Cytosol Plasma Membrane Bicellular Tight Junction Membrane Apical Plasma Membrane Cell Junction Centriolar Satellite Apical Junction Complex Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome Tight Junction Anchoring Junction
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Protein Domain Specific Binding Identical Protein Binding	Protein Binding
	Biological Process	Morphogenesis Of An Epithelial Sheet Plasma Membrane Organization Intracellular Protein Localization Gene Expression Establishment Or Maintenance Of Polarity Of Embryonic Epithelium Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Central Nervous System Neuron Development Cerebral Cortex Development Peripheral Nervous System Myelin Maintenance Myelin Assembly Protein Localization To Myelin Sheath Abaxonal Region Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Generation Of Neurons Protein Localization To Plasma Membrane	Establishment Of Apical/basal Cell Polarity Intracellular Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Tight Junction Assembly
Pathways		Tight junction interactions SARS-CoV-1 targets PDZ proteins in cell-cell junction SARS-CoV-2 targets PDZ proteins in cell-cell junction SARS-CoV-2 targets PDZ proteins in cell-cell junction	Tight junction interactions SARS-CoV-2 targets PDZ proteins in cell-cell junction
Drugs
Diseases
GWAS			3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30582445) Autism spectrum disorders (social interaction) ( 32624584) Daytime nap ( 33568662) Excessive daytime sleepiness ( 27992416) Sleep traits (multi-trait analysis) ( 27992416) Type 2 diabetes ( 30297969)
Interacting Genes		15 interacting genes: ARF6 CRB3 DLGAP4 FTCD GPRASP3 LIN7A MPP4 NEK9 NUMB PARD6B PATJ SNTG2 SOCS4 SRGAP2B TRAF2	35 interacting genes: ADGRB1 ASIC3 CACNG2 CEP57L1 CINP CLDN1 CNKSR2 CRB3 CRIPT DDX18 GIPC2 GLS2 GRIN2A GRIN2B GRIN2C GRIN2D HDAC7 HOMER1 KCNA4 KCNJ10 KCNJ15 KCNJ2 KIF1B MAPK12 NECAB2 NLGN2 NRXN2 PALS1 PARD3 PAX6 PHYH PRDM16 SCN4A SCN5A TJP3
Entrez ID		64398	10207
HPRD ID		09508	04434
Ensembl ID		ENSG00000072415	ENSG00000132849
Uniprot IDs		Q8N3R9	A0A2R8Y549 Q8NI35
PDB IDs		1Y76 3UIT 4UU5 4UU6 4WSI 7M4R 7NTJ 7NTK 7QCS	1VF6 2D92 2DAZ 2DB5 2DLU 2DM8 2DMZ 2EHR 4Q2N 6IRD
Enriched GO Terms of Interacting Partners?		Apical Part Of Cell Regulation Of Cell Junction Assembly Regulation Of Synapse Organization Bicellular Tight Junction Regulation Of Synapse Assembly Establishment Or Maintenance Of Cell Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Thioesterase Binding Cell Junction Organization Regulation Of Cellular Component Organization Apical Junction Complex Anchoring Junction Cell Cortex Cell-cell Junction Organization Tight Junction Cell Division Cell Junction Positive Regulation Of Cellular Component Biogenesis Erythrocyte Apoptotic Process TORC2 Complex Disassembly Glutamate Formimidoyltransferase Activity Formimidoyltetrahydrofolate Cyclodeaminase Activity Extracellular Exosome Regulation Of Dendritic Spine Development Glutamatergic Synapse Plasma Membrane TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding L-histidine Catabolic Process To Glutamate And Formate L-histidine Catabolic Process To Glutamate And Formamide Signaling Adaptor Activity Protein Localization To Cleavage Furrow Neuroblast Division In Subventricular Zone L27 Domain Binding Subapical Complex	Regulation Of Membrane Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Monoatomic Cation Channel Activity Regulation Of Synaptic Transmission, Glutamatergic NMDA Glutamate Receptor Activity Metal Ion Transport NMDA Selective Glutamate Receptor Complex Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Excitatory Chemical Synaptic Transmission Positive Regulation Of Excitatory Postsynaptic Potential Monoatomic Ion Channel Complex Inorganic Ion Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Protein Localization To Cell Junction Modulation Of Chemical Synaptic Transmission Monoatomic Ion Channel Activity Modulation Of Excitatory Postsynaptic Potential System Process Glutamate Receptor Signaling Pathway Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transport Regulation Of Neuronal Synaptic Plasticity Monoatomic Ion Transport Protein Localization To Synapse Regulation Of Nervous System Process Chemical Synaptic Transmission Trans-synaptic Signaling Postsynaptic Membrane Ionotropic Glutamate Receptor Signaling Pathway Synaptic Signaling Positive Regulation Of Synaptic Transmission Dendritic Spine Ligand-gated Monoatomic Ion Channel Activity Glutamate-gated Calcium Ion Channel Activity Plasma Membrane Transmembrane Transport Regulation Of System Process Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Glutamatergic Synapse Synapse Ligand-gated Ion Channel Signaling Pathway Synaptic Transmission, Glutamatergic Postsynaptic Density Membrane Protein Localization To Membrane Regulation Of Synaptic Plasticity Dendrite Membrane Depolarization Long-term Synaptic Potentiation
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