AZI2 and RB1CC1

Number of citations of the paper that reports this interaction (PubMedID 30853402)
35

Data Source:
BioGRID (pull down)

		AZI2	RB1CC1
Description		5-azacytidine induced 2	RB1 inducible coiled-coil 1
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GO Annotations	Cellular Component	Cytoplasm Serine/threonine Protein Kinase Complex	Phagophore Assembly Site Autophagosome Membrane Nucleus Cytoplasm Lysosome Vacuole Endoplasmic Reticulum Membrane Cytosol Organelle Membrane Nuclear Membrane Phagophore Assembly Site Membrane Atg1/ULK1 Kinase Complex
	Molecular Function	Protein Binding	Protein Binding Protein Kinase Binding Protein-membrane Adaptor Activity Molecular Adaptor Activity
	Biological Process	Mitotic Cell Cycle T Cell Activation Negative Regulation Of Canonical NF-kappaB Signal Transduction Dendritic Cell Proliferation Defense Response To Virus Type I Interferon-mediated Signaling Pathway Dendritic Cell Differentiation	Autophagosome Assembly Autophagy Of Mitochondrion Pexophagy Liver Development Autophagy Apoptotic Process Heart Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Autophagy Ribophagy Piecemeal Microautophagy Of The Nucleus Negative Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Cell Size Positive Regulation Of JNK Cascade Defense Response To Virus Reticulophagy Glycophagy Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Macroautophagy
Drugs
Diseases
GWAS		Cognitive decline (age-related) ( 28078323)	Body size at age 10 ( 32376654) Immunoglobulin light chain (AL) amyloidosis (liver involvement) ( 28679651) Mitochondrial DNA copy number (white blood cells) ( 30704525) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		16 interacting genes: APBA3 FAM107A GABARAP GABARAPL1 GABARAPL2 IKBKE MIB1 MTPAP N4BP1 RB1CC1 RNF31 TAX1BP1 TBK1 TICAM1 TRAF3 TXLNA	35 interacting genes: ATG12 AZI2 BAP1 BLID CALCOCO2 COP1 EPSTI1 ERRFI1 EXOC1 GABARAP GABARAPL1 GABARAPL2 GLCE GREB1 HBP1 IL13RA2 IL24 ITIH5 LYPD3 MADD MECOM MRC2 NSD3 PSMC3IP PTK2 PTK2B RNF20 SYN1 THRSP UBC UMPS VAPA VHL VPS45 WIF1
Entrez ID		64343	9821
HPRD ID		10577	06019
Ensembl ID		ENSG00000163512	ENSG00000023287
Uniprot IDs		Q9H6S1	Q8TDY2
PDB IDs		5EP6 5Z7G 5Z7L 7EA2 7EA7	6DCE 6GMA 7CZG 7CZM 7D0E 7EA2 7EAA 8SOI 8SQZ 8SRM 8W6B 8YFK 8YFL 8YFM 8YFN 9C82 9D34
Enriched GO Terms of Interacting Partners?		Autophagosome Cell Surface Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cellular Response To Nitrogen Starvation Ubiquitin Protein Ligase Binding Regulation Of Canonical NF-kappaB Signal Transduction Cell Surface Pattern Recognition Receptor Signaling Pathway Autophagy Autophagosome Membrane Macroautophagy Phosphatidylethanolamine Binding GABA Receptor Binding Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Cytoplasm Autophagy Of Mitochondrion Serine/threonine Protein Kinase Complex Activation Of Innate Immune Response Positive Regulation Of Type I Interferon Production Activation Of Immune Response Autophagosome Assembly Regulation Of Innate Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Defense Response Autophagosome Organization Response To Other Organism Cellular Response To Nutrient Levels Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Defense Response Defense Response To Virus Regulation Of Type I Interferon Production Positive Regulation Of Innate Immune Response Beta-tubulin Binding Response To External Biotic Stimulus Defense Response Regulation Of Immune Response Immune System Process Response To Stress Immune Response-activating Signaling Pathway Autophagosome Maturation Pattern Recognition Receptor Signaling Pathway Type I Interferon-mediated Signaling Pathway Innate Immune Response Vacuole Organization Positive Regulation Of Autophagy Positive Regulation Of Immune Response Innate Immune Response-activating Signaling Pathway Cell Surface Receptor Signaling Pathway Mitophagy Regulation Of Interferon-beta Production Response To Virus	Autophagosome Membrane Autophagosome Cellular Response To Nitrogen Starvation Autophagosome Maturation Phosphatidylethanolamine Binding GABA Receptor Binding Autophagy Of Mitochondrion Macroautophagy Autophagosome Assembly Autophagosome Organization Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Beta-tubulin Binding Signal Complex Assembly Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein-containing Complex Disassembly Mitophagy Glycophagy Epidermal Growth Factor Receptor Signaling Pathway Apoptotic Process Ubiquitin Protein Ligase Binding Autophagy Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Tag Activity Vacuole Organization Regulation Of Autophagosome Maturation Programmed Cell Death Cell Death ERBB Signaling Pathway Protein Localization To Endoplasmic Reticulum Positive Regulation Of Proteolysis Glycogen Catabolic Process Regulation Of Proteolysis Histone H3 Methyltransferase Activity Catabolic Process Polysaccharide Catabolic Process Regulation Of Macrophage Chemotaxis Cellular Response To Fluid Shear Stress Neurotransmitter Receptor Regulator Activity Orotidine-5'-phosphate Decarboxylase Activity Orotate Phosphoribosyltransferase Activity Nucleate Erythrocyte Differentiation Thrombocyte Differentiation Golgi Membrane Phospholipid Binding Heparosan-N-sulfate-glucuronate 5-epimerase Activity Meiotic Joint Molecule Formation DNA Recombinase Auxiliary Factor Complex Recombinase Activator Activity Meiotic Strand Invasion Involved In Reciprocal Meiotic Recombination Histone H3K4 Dimethyltransferase Activity
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