COP1 and RB1CC1

Number of citations of the paper that reports this interaction (PubMedID 23289756)
36

Data Source:
BioGRID (protein complementation assay)

		COP1	RB1CC1
Description		COP1 E3 ubiquitin ligase	RB1 inducible coiled-coil 1
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GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Cul4A-RING E3 Ubiquitin Ligase Complex	Phagophore Assembly Site Autophagosome Membrane Nucleus Cytoplasm Lysosome Vacuole Endoplasmic Reticulum Membrane Cytosol Organelle Membrane Nuclear Membrane Phagophore Assembly Site Membrane Atg1/ULK1 Kinase Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Protein Kinase Binding Protein-membrane Adaptor Activity Molecular Adaptor Activity
	Biological Process	Response To Ionizing Radiation Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Autophagosome Assembly Autophagy Of Mitochondrion Pexophagy Liver Development Autophagy Apoptotic Process Heart Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Autophagy Ribophagy Piecemeal Microautophagy Of The Nucleus Negative Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Cell Size Positive Regulation Of JNK Cascade Defense Response To Virus Reticulophagy Glycophagy Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Autodegradation of the E3 ubiquitin ligase COP1 Neddylation	Macroautophagy
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823)	Body size at age 10 ( 32376654) Immunoglobulin light chain (AL) amyloidosis (liver involvement) ( 28679651) Mitochondrial DNA copy number (white blood cells) ( 30704525) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		17 interacting genes: CDKN1B CUL4B DET1 ETS1 ETS2 GATA2 JUN JUND MLF1 PTPN1 RB1CC1 SFN SIPA1 TP53 UBE2D1 UBE2D2 YWHAZ	35 interacting genes: ATG12 AZI2 BAP1 BLID CALCOCO2 COP1 EPSTI1 ERRFI1 EXOC1 GABARAP GABARAPL1 GABARAPL2 GLCE GREB1 HBP1 IL13RA2 IL24 ITIH5 LYPD3 MADD MECOM MRC2 NSD3 PSMC3IP PTK2 PTK2B RNF20 SYN1 THRSP UBC UMPS VAPA VHL VPS45 WIF1
Entrez ID		64326	9821
HPRD ID		07455	06019
Ensembl ID		ENSG00000143207	ENSG00000023287
Uniprot IDs		Q8NHY2 X5D7N8 X5DNY7	Q8TDY2
PDB IDs		5HQG 5IGQ	6DCE 6GMA 7CZG 7CZM 7D0E 7EA2 7EAA 8SOI 8SQZ 8SRM 8W6B 8YFK 8YFL 8YFM 8YFN 9C82 9D34
Enriched GO Terms of Interacting Partners?		Cul4A-RING E3 Ubiquitin Ligase Complex Negative Regulation Of Cell Population Proliferation Ubiquitin Protein Ligase Binding Regulation Of Cell Cycle Positive Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of MiRNA Transcription RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleus Regulation Of MiRNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Stress Response To Antibiotic Regulation Of Primary Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Phosphoserine Residue Binding Transcription Factor AP-1 Complex Negative Regulation Of Catalytic Activity Negative Regulation Of Phosphate Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Process Regulation Of Cell Cycle G1/S Phase Transition DNA-binding Transcription Factor Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Repressor Complex Regulation Of Programmed Cell Death Negative Regulation Of Macromolecule Metabolic Process Regulation Of Intracellular Signal Transduction Cellular Response To Antibiotic Negative Regulation Of Protein Kinase Activity DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Kinase Activity Protein Kinase Binding General Transcription Initiation Factor Binding Protein-containing Complex Negative Regulation Of Neuroblast Proliferation Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Transcription Regulator Complex	Autophagosome Membrane Autophagosome Cellular Response To Nitrogen Starvation Autophagosome Maturation Phosphatidylethanolamine Binding GABA Receptor Binding Autophagy Of Mitochondrion Macroautophagy Autophagosome Assembly Autophagosome Organization Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Beta-tubulin Binding Signal Complex Assembly Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein-containing Complex Disassembly Mitophagy Glycophagy Epidermal Growth Factor Receptor Signaling Pathway Apoptotic Process Ubiquitin Protein Ligase Binding Autophagy Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Tag Activity Vacuole Organization Regulation Of Autophagosome Maturation Programmed Cell Death Cell Death ERBB Signaling Pathway Protein Localization To Endoplasmic Reticulum Positive Regulation Of Proteolysis Glycogen Catabolic Process Regulation Of Proteolysis Histone H3 Methyltransferase Activity Catabolic Process Polysaccharide Catabolic Process Regulation Of Macrophage Chemotaxis Cellular Response To Fluid Shear Stress Neurotransmitter Receptor Regulator Activity Orotidine-5'-phosphate Decarboxylase Activity Orotate Phosphoribosyltransferase Activity Nucleate Erythrocyte Differentiation Thrombocyte Differentiation Golgi Membrane Phospholipid Binding Heparosan-N-sulfate-glucuronate 5-epimerase Activity Meiotic Joint Molecule Formation DNA Recombinase Auxiliary Factor Complex Recombinase Activator Activity Meiotic Strand Invasion Involved In Reciprocal Meiotic Recombination Histone H3K4 Dimethyltransferase Activity
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