MOAP1 and CAMK2D

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		MOAP1	CAMK2D
Description		modulator of apoptosis 1	calcium/calmodulin dependent protein kinase II delta
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Calcium- And Calmodulin-dependent Protein Kinase Complex Postsynaptic Density Membrane Sarcoplasmic Reticulum Endocytic Vesicle Membrane Sarcoplasmic Reticulum Membrane Sarcolemma Neuron Projection
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Sodium Channel Inhibitor Activity Titin Binding Identical Protein Binding Protein Homodimerization Activity Transmembrane Transporter Binding Protein Serine Kinase Activity
	Biological Process	Autophagy Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Protein Insertion Into Mitochondrial Membrane Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Autophagosome Assembly	Regulation Of Cell Growth Regulation Of The Force Of Heart Contraction Regulation Of Membrane Depolarization Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Regulation Of Heart Contraction Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Neuronal Synaptic Plasticity Relaxation Of Cardiac Muscle Long-term Synaptic Potentiation Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cellular Localization Cellular Response To Calcium Ion Cardiac Muscle Cell Contraction Regulation Of Heart Rate By Cardiac Conduction Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Relaxation Of Cardiac Muscle Negative Regulation Of Sodium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Regulation Of Protein Localization To Plasma Membrane
Pathways			CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs			2-[4-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl]iminocyclohexa-2,5-dien-1-yl]acetonitrile (3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE Fostamatinib
Diseases
GWAS		Body mass index ( 26426971) Endometriosis ( 23472165) Migraine ( 27182965)	Atrial fibrillation ( 30061737 29892015) Chronic lymphocytic leukemia ( 24292274 28165464) Chronotype ( 30696823) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Femur bone mineral density x serum urate levels interaction ( 34046847) Hip circumference adjusted for BMI ( 28552196) Non-small cell lung cancer (survival) ( 25145502) P wave duration ( 28794112) Parkinson's disease ( 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) PR interval ( 30046033 32439900) Small vessel stroke (CCS and TOAST classification) ( 32047268) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149) TPE interval (resting) ( 32386560) White matter integrity (bipolar disorder risk interaction) ( 23218918)
Interacting Genes		28 interacting genes: BAX BCL2 BCL2L1 CACNA1A CAMK2D CCDC85B DPPA2 FXR1 FZR1 HUNK LATS1 LCOR MAGEH1 MBIP MEOX2 PNMA5 PPP2R3C RASSF1 RUSC1 SQSTM1 THOC1 TNFRSF10A TNFRSF1A TRIM68 UBQLN2 UBQLN4 UBR5 ZMYND12	30 interacting genes: ACTN2 ARL2BP BANP CAMK2B CD5 CREM EPHA10 ERCC8 FAM171B FKBP1B FNDC3B GRIN2B HNMT IFNGR2 MOAP1 MRPL11 RNF4 RPS18 RPS4X SMARCB1 SPATA24 SRPK1 STAT1 TNPO2 TNPO3 TTC5 UBC UBE2I VIM WASF3
Entrez ID		64112	817
HPRD ID		17580	09653
Ensembl ID		ENSG00000165943	ENSG00000145349
Uniprot IDs		Q96BY2	A0A8V8TN60 A0A8V8TN65 A0A8V8TN88 A0A8V8TNA1 A0A8V8TNA7 A0A8V8TPJ8 A0A8V8TPY4 A0A994J516 A0A994J5B0 D6R938 E9PBG7 E9PF82 Q13557
PDB IDs		7LGC	2VN9 2W2C 2WEL 3GP2 5VLO 6AYW 7ZRP 7ZRQ 8USO
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death BH3 Domain Binding Nucleus Bcl-2 Family Protein Complex Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Extrinsic Apoptotic Signaling Pathway Identical Protein Binding Apoptotic Process Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Mitochondrial Membrane Potential Programmed Cell Death Involved In Cell Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Nitrogen Utilization Release Of Cytochrome C From Mitochondria Retinal Cell Programmed Cell Death Dendritic Cell Apoptotic Process Programmed Cell Death Cell Death B Cell Homeostasis Regulation Of Metabolic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand DNA Damage Response Channel Activity Positive Regulation Of Apoptotic Process Involved In Morphogenesis Cytoplasm Intracellular Membraneless Organelle Epithelial Cell Apoptotic Process Intracellular Signal Transduction Ovarian Follicle Development Leukocyte Apoptotic Process Positive Regulation Of Apoptotic Process Involved In Development Positive Regulation Of Developmental Pigmentation Molecular Condensate Scaffold Activity Regulation Of Membrane Depolarization Protein Polyubiquitination Response To Gamma Radiation Negative Regulation Of Dendritic Cell Apoptotic Process Regulation Of Macromolecule Metabolic Process Regulation Of Mitochondrial Membrane Permeability Cellular Response To Stress Lymphocyte Homeostasis Regulation Of Cellular Localization Apoptotic Mitochondrial Changes Apoptotic Signaling Pathway B Cell Apoptotic Process Intrinsic Apoptotic Signaling Pathway Calcium Ion Transport Into Cytosol Regulation Of Membrane Permeability Regulation Of Developmental Pigmentation	Cytoplasm Nuclear Matrix
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