CAMK2D and ERCC8

Number of citations of the paper that reports this interaction (PubMedID 26871637)
43

Data Source:
BioGRID (two hybrid)

		CAMK2D	ERCC8
Description		calcium/calmodulin dependent protein kinase II delta	ERCC excision repair 8, CSA ubiquitin ligase complex subunit
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Calcium- And Calmodulin-dependent Protein Kinase Complex Postsynaptic Density Membrane Sarcoplasmic Reticulum Endocytic Vesicle Membrane Sarcoplasmic Reticulum Membrane Sarcolemma Neuron Projection	Nucleotide-excision Repair Complex Nucleus Nucleoplasm Chromosome Nuclear Matrix Cul4A-RING E3 Ubiquitin Ligase Complex Protein-containing Complex Perikaryon Cul4-RING E3 Ubiquitin Ligase Complex Site Of DNA Damage
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Sodium Channel Inhibitor Activity Titin Binding Identical Protein Binding Protein Homodimerization Activity Transmembrane Transporter Binding Protein Serine Kinase Activity	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Regulation Of Cell Growth Regulation Of The Force Of Heart Contraction Regulation Of Membrane Depolarization Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Regulation Of Heart Contraction Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Neuronal Synaptic Plasticity Relaxation Of Cardiac Muscle Long-term Synaptic Potentiation Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cellular Localization Cellular Response To Calcium Ion Cardiac Muscle Cell Contraction Regulation Of Heart Rate By Cardiac Conduction Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Relaxation Of Cardiac Muscle Negative Regulation Of Sodium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Regulation Of Protein Localization To Plasma Membrane	Single Strand Break Repair Protein Polyubiquitination DNA Repair Transcription-coupled Nucleotide-excision Repair DNA Damage Response Response To Oxidative Stress Response To UV Response To X-ray Response To Auditory Stimulus Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Repair Protein Autoubiquitination Regulation Of Transcription-coupled Nucleotide-excision Repair Double-strand Break Repair Via Classical Nonhomologous End Joining
Pathways		CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants Signaling by RAF1 mutants	Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation
Drugs		2-[4-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl]iminocyclohexa-2,5-dien-1-yl]acetonitrile (3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE Fostamatinib
Diseases			Cockayne syndrome Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Atrial fibrillation ( 30061737 29892015) Chronic lymphocytic leukemia ( 24292274 28165464) Chronotype ( 30696823) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Femur bone mineral density x serum urate levels interaction ( 34046847) Hip circumference adjusted for BMI ( 28552196) Non-small cell lung cancer (survival) ( 25145502) P wave duration ( 28794112) Parkinson's disease ( 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) PR interval ( 30046033 32439900) Small vessel stroke (CCS and TOAST classification) ( 32047268) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149) TPE interval (resting) ( 32386560) White matter integrity (bipolar disorder risk interaction) ( 23218918)	Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		30 interacting genes: ACTN2 ARL2BP BANP CAMK2B CD5 CREM EPHA10 ERCC8 FAM171B FKBP1B FNDC3B GRIN2B HNMT IFNGR2 MOAP1 MRPL11 RNF4 RPS18 RPS4X SMARCB1 SPATA24 SRPK1 STAT1 TNPO2 TNPO3 TTC5 UBC UBE2I VIM WASF3	13 interacting genes: ADAMTS6 CAMK2D CBR1 CSNK2B DDB1 ERCC6 GTF2H2 POLR2A RBX1 TOP1 UQCRQ UVSSA XAB2
Entrez ID		817	1161
HPRD ID		09653	07523
Ensembl ID		ENSG00000145349	ENSG00000049167
Uniprot IDs		A0A8V8TN60 A0A8V8TN65 A0A8V8TN88 A0A8V8TNA1 A0A8V8TNA7 A0A8V8TPJ8 A0A8V8TPY4 A0A994J516 A0A994J5B0 D6R938 E9PBG7 E9PF82 Q13557	A0A0S2Z3L1 B3KPW7 B4DGZ9 Q13216
PDB IDs		2VN9 2W2C 2WEL 3GP2 5VLO 6AYW 7ZRP 7ZRQ 8USO	4A11 6FCV 7OO3 7OOB 7OOP 7OPC 7OPD 8B3D 8B3F 8B3G 8B3I 8QH5 9BZ0 9ER2 9FD2
Enriched GO Terms of Interacting Partners?		Cytoplasm Nuclear Matrix	Nucleotide-excision Repair Transcription-coupled Nucleotide-excision Repair Response To UV DNA Metabolic Process Response To Radiation DNA-templated Transcription DNA Repair Response To Light Stimulus Site Of DNA Damage Base-excision Repair, AP Site Formation Via Deaminated Base Removal Cul4B-RING E3 Ubiquitin Ligase Complex DNA-templated Transcription Elongation DNA Damage Response Nucleobase-containing Compound Biosynthetic Process Nucleic Acid Metabolic Process Macromolecule Metabolic Process Cul4A-RING E3 Ubiquitin Ligase Complex Prp19 Complex Transcription By RNA Polymerase II Nucleoplasm Base-excision Repair, AP Site Formation Protein Modification Process Chromatin-protein Adaptor Activity Nucleobase-containing Compound Metabolic Process Cullin Family Protein Binding Cul4-RING E3 Ubiquitin Ligase Complex RNA Metabolic Process Macromolecule Biosynthetic Process Protein Metabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Transcription Elongation By RNA Polymerase II Cellular Response To Stress Prostaglandin E2 9-reductase Activity 15-hydroxyprostaglandin Dehydrogenase (NADP+) Activity Type I Interferon-mediated Signaling Pathway Response To Gamma Radiation Pons Development Subthalamus Development Protein Ubiquitination Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Interferon-mediated Signaling Pathway 15-hydroxyprostaglandin-D Dehydrogenase (NADP+) Activity S-nitrosoglutathione Reductase (NADPH) Activity Protein Modification By Small Protein Conjugation Chromosome Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Dense Fibrillar Component Generation Of Catalytic Spliceosome For First Transesterification Step RNA Polymerase Inhibitor Activity
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