CENPK and PEX14

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CENPK	PEX14
Description		centromere protein K	peroxisomal biogenesis factor 14
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Inner Kinetochore Nucleus Nucleoplasm Chromosome Cytosol	Fibrillar Center Nucleus Peroxisome Peroxisomal Membrane Cytosol Membrane Protein-containing Complex Peroxisomal Importomer Complex
	Molecular Function	Protein Binding	Transcription Corepressor Activity Signaling Receptor Binding Protein Binding Microtubule Binding Protein Transmembrane Transporter Activity Protein-macromolecule Adaptor Activity Identical Protein Binding Beta-tubulin Binding
	Biological Process	Mitotic Sister Chromatid Segregation Chromosome Segregation Kinetochore Assembly	Protein Monoubiquitination Peroxisome Organization Protein Transport Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Docking Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Receptor Recycling Negative Regulation Of Protein Binding Microtubule Anchoring Cellular Response To Reactive Oxygen Species Peroxisome Transport Along Microtubule Protein Unfolding Negative Regulation Of DNA-binding Transcription Factor Activity Protein Import Into Peroxisome Matrix, Substrate Release Negative Regulation Of DNA-templated Transcription Protein-containing Complex Assembly
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	E3 ubiquitin ligases ubiquitinate target proteins Peroxisomal protein import Peroxisomal protein import Class I peroxisomal membrane protein import
Drugs
Diseases			Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Diverticular disease ( 30177863) Subcortical volume (MOSTest) ( 32665545)	Asthma ( 34103634 32296059 27182965) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 29059683 27117709 23535729 23535733) Breast cancer (estrogen-receptor negative) ( 27117709) Breast size ( 27182965) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Facial morphology ( 31763980) Femur bone mineral density x serum urate levels interaction ( 34046847) Hand grip strength ( 29313844) Heel bone mineral density ( 30598549) LDL cholesterol ( 30275531) Male-pattern baldness ( 28196072) Metabolite levels ( 23823483) Optic nerve measurement (rim area) ( 20395239) Prostate cancer ( 25217961) Refractive error ( 32231278) Self-reported allergy ( 23817569) Total cholesterol levels ( 30275531)
Interacting Genes		10 interacting genes: AP1G2 HSPB1 MRFAP1L1 PCBD2 PEX14 RTN4IP1 SOX6 TRIM55 TRIM63 WASHC3	24 interacting genes: ACACB AFTPH CAMTA1 CBFA2T2 CENPK COPS4 FSD1 GET3 HDAC1 KDM5D MARF1 MED8 MTNR1A NEDD9 NFE2 NFKBIL1 OGT PEX19 PEX26 PEX5 PEX7 SMARCC2 TONSL ZHX1
Entrez ID		64105	5195
HPRD ID		13323	03477
Ensembl ID		ENSG00000123219	ENSG00000142655
Uniprot IDs		D6RHD3 D6RJF0 Q9BS16	O75381
PDB IDs		7PB4 7PKN 7QOO 7R5S 7R5V 7XHN 7XHO 7YWX 7YYH	2W84 2W85 4BXU 9GAG
Enriched GO Terms of Interacting Partners?		Contractile Muscle Fiber	Establishment Of Protein Localization To Peroxisome Peroxisomal Membrane Transport Peroxisome Organization Protein Import Into Peroxisome Membrane Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix Peroxisome Peroxisomal Membrane Peroxisome Membrane Targeting Sequence Binding Nucleoplasm Intracellular Protein Transmembrane Transport Protein Carrier Chaperone Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Unfolding Nucleus Fatty Acid Oxidation Establishment Of Protein Localization To Membrane Protein Transmembrane Transport Protein Localization To Organelle Lipid Oxidation Nucleosome Disassembly Sin3-type Complex Protein-DNA Complex Disassembly Protein-containing Complex Negative Regulation Of Stem Cell Population Maintenance Receptor Recycling Circadian Rhythm Chromatin Organization Lipid Modification Regulation Of Androgen Receptor Signaling Pathway Protein-containing Complex Disassembly Lactic Acid Secretion Intracellular Aspartate Homeostasis Nucleosomal DNA Binding Establishment Of Protein Localization To Organelle Peroxisome Matrix Targeting Signal-2 Binding Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Receptor Metabolic Process Positive Regulation Of Stem Cell Population Maintenance Peroxisomal Matrix Malonyl-CoA Biosynthetic Process Protein-containing Complex Organization Acetyl-CoA Carboxylase Activity Krueppel-associated Box Domain Binding Positive Regulation Of Immunological Synapse Formation Fatty Acid Beta-oxidation Peroxisome Matrix Targeting Signal-1 Binding
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