GOLPH3 and B4GALT4

Number of citations of the paper that reports this interaction (PubMedID 34473204)
68

Data Source:
BioGRID (pull down)

		GOLPH3	B4GALT4
Description		golgi phosphoprotein 3	beta-1,4-galactosyltransferase 4
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Mitochondrion Mitochondrial Intermembrane Space Endosome Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Membrane Golgi Cisterna Golgi Cisterna Membrane	Golgi Membrane Extracellular Region Golgi Apparatus Membrane
	Molecular Function	Protein Binding Lipid Binding Enzyme Binding Phosphatidylinositol-4-phosphate Binding Cargo Adaptor Activity	N-acetyllactosamine Synthase Activity Protein Binding Galactosyltransferase Activity Transferase Activity Glycosyltransferase Activity UDP-galactosyltransferase Activity Metal Ion Binding
	Biological Process	Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Golgi Organization Glycoprotein Biosynthetic Process Protein Secretion Gene Expression Regulation Of Mitochondrion Organization Protein Transport Cell Migration Lamellipodium Assembly Positive Regulation Of TOR Signaling Golgi To Plasma Membrane Protein Transport Negative Regulation Of Apoptotic Process Protein Retention In Golgi Apparatus Golgi Vesicle Budding Positive Regulation Of Protein Secretion Leukocyte Tethering Or Rolling Cell Adhesion Molecule Production Cellular Response To Rapamycin Golgi Ribbon Formation Asymmetric Golgi Ribbon Formation Protein Targeting To Golgi Apparatus	Lactosylceramide Biosynthetic Process Carbohydrate Metabolic Process Protein Glycosylation Lipid Metabolic Process Membrane Lipid Metabolic Process Keratan Sulfate Proteoglycan Biosynthetic Process Glycosylation
Pathways			Keratan sulfate biosynthesis N-Glycan antennae elongation
Drugs			N-Acetylglucosamine
Diseases
GWAS		Metabolite levels ( 23823483)	Clozapine-induced cytotoxicity ( 25656473) First year height change in growth hormone-treated short stature ( 32652002) Gemcitabine-induced early high-grade neutropenia in pancreatic cancer ( 30889042) Survival in pancreatic cancer ( 28470677)
Interacting Genes		23 interacting genes: ARL6IP1 B4GALT4 C1GALT1 CANT1 DIPK2A EBAG9 EXT1 FAM20B FAM3C GALNT2 GALNT6 GALNT7 GCNT1 GLG1 GLT8D1 GOLIM4 GOLM2 MAN1B1 MGAT2 PGAP4 POMGNT1 TPST1 TPST2	4 interacting genes: GOLPH3 GOLPH3L POLE4 TIGIT
Entrez ID		64083	8702
HPRD ID		11007	04930
Ensembl ID		ENSG00000113384	ENSG00000121578
Uniprot IDs		Q9H4A6	B2RAZ5 B3KM35 E7ETS9 O60513
PDB IDs		3KN1
Enriched GO Terms of Interacting Partners?		Golgi Apparatus Golgi Membrane Glycoprotein Metabolic Process Glycosyltransferase Activity Glycoprotein Biosynthetic Process Protein Glycosylation Macromolecule Glycosylation Carbohydrate Derivative Metabolic Process Glycosylation Carbohydrate Derivative Biosynthetic Process Protein O-linked Glycosylation Protein O-linked Glycosylation Via N-acetyl-galactosamine Transferase Activity Macromolecule Biosynthetic Process Protein Modification Process Protein Metabolic Process Membrane Polypeptide N-acetylgalactosaminyltransferase Activity Proteoglycan Biosynthetic Process Protein-tyrosine Sulfotransferase Activity Carbohydrate Binding Proteoglycan Metabolic Process Macromolecule Metabolic Process Manganese Ion Binding Golgi Cisterna Membrane Carbohydrate Metabolic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Sulfation Acetylglucosaminyltransferase Activity UDP-glycosyltransferase Activity Leukocyte Tethering Or Rolling Golgi Lumen Leukocyte Adhesion To Vascular Endothelial Cell Viral Protein Processing Basement Membrane Organization Bone Morphogenesis Lymphocyte Adhesion To Endothelial Cell Of High Endothelial Venule Perichondral Bone Morphogenesis Sweat Gland Development Smoothened Signaling Pathway Involved In Lung Development Golgi Stack Alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase Activity Peptidyl-tyrosine Sulfation Trans-Golgi Network Protein Homodimerization Activity N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase Activity Mesenchymal Cell Differentiation Involved In Bone Development Stomach Development Heparan Sulfate N-acetylglucosaminyltransferase Activity Leukocyte Cell-cell Adhesion	Golgi Vesicle Budding Cargo Adaptor Activity Protein Targeting To Golgi Apparatus Golgi Cisterna Phosphatidylinositol-4-phosphate Binding Golgi To Plasma Membrane Protein Transport Vesicle Budding From Membrane Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Golgi Cisterna Membrane Post-Golgi Vesicle-mediated Transport Golgi Organization Vesicle-mediated Transport To The Plasma Membrane Positive Regulation Of Protein Secretion Asymmetric Golgi Ribbon Formation Protein Localization To Plasma Membrane Trans-Golgi Network Cell Adhesion Molecule Production Cellular Response To Rapamycin Protein Targeting Establishment Of Protein Localization To Membrane Protein Retention In Golgi Apparatus Protein Localization To Cell Periphery Epsilon DNA Polymerase Complex Positive Regulation Of Protein Transport Regulation Of Protein Secretion Response To Rapamycin Golgi Vesicle Transport Positive Regulation Of Secretion By Cell Vesicle Organization Positive Regulation Of Secretion Positive Regulation Of Establishment Of Protein Localization Protein Localization To Membrane Lipid Binding Establishment Of Protein Localization To Organelle Golgi Ribbon Formation Cellular Response To Ether ATAC Complex Regulation Of Protein Transport Positive Regulation Of Protein Localization Negative Regulation Of Interleukin-12 Production Leukocyte Tethering Or Rolling DNA-directed DNA Polymerase Activity Response To Ether Localization Within Membrane Regulation Of Establishment Of Protein Localization Leukocyte Adhesion To Vascular Endothelial Cell Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Secretion By Cell
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