GOLPH3 and GALNT2

Number of citations of the paper that reports this interaction (PubMedID 34473204)
68

Data Source:
BioGRID (pull down)

		GOLPH3	GALNT2
Description		golgi phosphoprotein 3	polypeptide N-acetylgalactosaminyltransferase 2
Image
GO Annotations	Cellular Component	Golgi Membrane Mitochondrion Mitochondrial Intermembrane Space Endosome Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Membrane Golgi Cisterna Golgi Cisterna Membrane	Golgi Membrane Extracellular Region Endoplasmic Reticulum Membrane Golgi Apparatus Golgi Stack Membrane Golgi Cisterna Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Lipid Binding Enzyme Binding Phosphatidylinositol-4-phosphate Binding Cargo Adaptor Activity	Polypeptide N-acetylgalactosaminyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Manganese Ion Binding Carbohydrate Binding Metal Ion Binding
	Biological Process	Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Golgi Organization Glycoprotein Biosynthetic Process Protein Secretion Gene Expression Regulation Of Mitochondrion Organization Protein Transport Cell Migration Lamellipodium Assembly Positive Regulation Of TOR Signaling Golgi To Plasma Membrane Protein Transport Negative Regulation Of Apoptotic Process Protein Retention In Golgi Apparatus Golgi Vesicle Budding Positive Regulation Of Protein Secretion Leukocyte Tethering Or Rolling Cell Adhesion Molecule Production Cellular Response To Rapamycin Golgi Ribbon Formation Asymmetric Golgi Ribbon Formation Protein Targeting To Golgi Apparatus	Positive Regulation Of Immunoglobulin Production Protein Glycosylation Protein O-linked Glycosylation Protein O-linked Glycosylation Via N-acetyl-galactosamine Protein Maturation
Pathways			COPI-independent Golgi-to-ER retrograde traffic O-linked glycosylation of mucins
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Carotid intima media thickness ( 26343869) Circulating myeloperoxidase levels (serum) ( 23620142) Coronary artery disease ( 29212778) Dementia and core Alzheimer's disease neuropathologic changes ( 25188341) Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer ( 28429243) Fibrinogen levels ( 28107422) HDL cholesterol ( 30275531 18193043 18193044 19060906 25961943 24097068 20864672 20686565) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Hematology traits ( 23303382) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High density lipoprotein cholesterol levels ( 33339817 29403010) Intake of sweets ( 31005972) Mean corpuscular hemoglobin concentration ( 32888494) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 31589552 22399527) Metabolite levels ( 22916037) Platelet count ( 27863252 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Postburn scar pliability ( 30595539) Red cell distribution width ( 28957414 27863252 32888494) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Triglyceride levels ( 32902719 33339817 32203549 32154731 30698716 29403010 28334899) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 30275531 25961943 24097068 20686565 18193044 18193043)
Interacting Genes		23 interacting genes: ARL6IP1 B4GALT4 C1GALT1 CANT1 DIPK2A EBAG9 EXT1 FAM20B FAM3C GALNT2 GALNT6 GALNT7 GCNT1 GLG1 GLT8D1 GOLIM4 GOLM2 MAN1B1 MGAT2 PGAP4 POMGNT1 TPST1 TPST2	10 interacting genes: BCL2L13 CDC42 COQ9 GOLPH3 GOLPH3L KASH5 LCOR LMNA MRM3 MUC1
Entrez ID		64083	2590
HPRD ID		11007	03782
Ensembl ID		ENSG00000113384	ENSG00000143641
Uniprot IDs		Q9H4A6	A0A1L7NY50 B7Z6K2 Q10471
PDB IDs		3KN1	2FFU 2FFV 4D0T 4D0Z 4D11 5AJN 5AJO 5AJP 5FV9 5NDF 6E7I 6EGS 6NQT
Enriched GO Terms of Interacting Partners?		Golgi Apparatus Golgi Membrane Glycoprotein Metabolic Process Glycosyltransferase Activity Glycoprotein Biosynthetic Process Protein Glycosylation Macromolecule Glycosylation Carbohydrate Derivative Metabolic Process Glycosylation Carbohydrate Derivative Biosynthetic Process Protein O-linked Glycosylation Protein O-linked Glycosylation Via N-acetyl-galactosamine Transferase Activity Macromolecule Biosynthetic Process Protein Modification Process Protein Metabolic Process Membrane Polypeptide N-acetylgalactosaminyltransferase Activity Proteoglycan Biosynthetic Process Protein-tyrosine Sulfotransferase Activity Carbohydrate Binding Proteoglycan Metabolic Process Macromolecule Metabolic Process Manganese Ion Binding Golgi Cisterna Membrane Carbohydrate Metabolic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Sulfation Acetylglucosaminyltransferase Activity UDP-glycosyltransferase Activity Leukocyte Tethering Or Rolling Golgi Lumen Leukocyte Adhesion To Vascular Endothelial Cell Viral Protein Processing Basement Membrane Organization Bone Morphogenesis Lymphocyte Adhesion To Endothelial Cell Of High Endothelial Venule Perichondral Bone Morphogenesis Sweat Gland Development Smoothened Signaling Pathway Involved In Lung Development Golgi Stack Alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase Activity Peptidyl-tyrosine Sulfation Trans-Golgi Network Protein Homodimerization Activity N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase Activity Mesenchymal Cell Differentiation Involved In Bone Development Stomach Development Heparan Sulfate N-acetylglucosaminyltransferase Activity Leukocyte Cell-cell Adhesion	Golgi Vesicle Budding Cargo Adaptor Activity Protein Targeting To Golgi Apparatus Golgi Cisterna Golgi Organization Nuclear Migration Phosphatidylinositol-4-phosphate Binding Nucleus Localization Vesicle Budding From Membrane Golgi To Plasma Membrane Protein Transport Membrane Organization Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Isoprenoid Binding Golgi Cisterna Membrane GBD Domain Binding Storage Vacuole DNA Double-strand Break Attachment To Nuclear Envelope Chromosome Localization Establishment Of Protein Localization To Organelle Structural Constituent Of Nuclear Lamina RRNA (guanosine-2'-O-)-methyltransferase Activity Lipid Binding Asymmetric Golgi Ribbon Formation Meiotic Spindle Pole Organelle Organization Aerobic Respiration Endothelin Receptor Signaling Pathway Involved In Heart Process Cellular Respiration RRNA 2'-O-methylation Post-Golgi Vesicle-mediated Transport Cell Adhesion Molecule Production Cellular Response To Rapamycin Regulation Of Mitochondrion Organization Organelle Localization Apolipoprotein A-I Receptor Binding Neuropilin Signaling Pathway Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Protein Retention In Golgi Apparatus Vesicle-mediated Transport To The Plasma Membrane Lamin Filament Localization Within Membrane Nuclear Pore Localization
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