SEL1L and HYOU1

Number of citations of the paper that reports this interaction (PubMedID 27030672)
44

Data Source:
BioGRID (pull down)

		SEL1L	HYOU1
Description		SEL1L adaptor subunit of SYVN1 ubiquitin ligase	hypoxia up-regulated 1
Image			No pdb structure
GO Annotations	Cellular Component	Hrd1p Ubiquitin Ligase Complex Hrd1p Ubiquitin Ligase ERAD-L Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Derlin-1 Retrotranslocation Complex	Extracellular Region Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Lumen Smooth Endoplasmic Reticulum Focal Adhesion Membrane Endoplasmic Reticulum Chaperone Complex Extracellular Exosome Endocytic Vesicle Lumen
	Molecular Function	Protein Binding	Nucleotide Binding Adenyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Unfolded Protein Binding Protein-folding Chaperone Binding ATP-dependent Protein Folding Chaperone
	Biological Process	Triglyceride Metabolic Process Notch Signaling Pathway Protein Secretion Protein Transport Retrograde Protein Transport, ER To Cytosol Response To Endoplasmic Reticulum Stress ERAD Pathway Protein Stabilization	Response To Ischemia Protein Folding Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Response To Stress Response To Endoplasmic Reticulum Stress Negative Regulation Of Apoptotic Process Cellular Response To Hypoxia Regulation Of Cellular Response To Stress Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Pre-NOTCH Processing in Golgi ABC-family proteins mediated transport Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Defective CFTR causes cystic fibrosis ER Quality Control Compartment (ERQC) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	Scavenging by Class F Receptors Scavenging by Class F Receptors XBP1(S) activates chaperone genes
Drugs
Diseases
GWAS		Body size at age 10 ( 32376654) Cadmium levels ( 26025379) Intraocular pressure ( 29617998) Lymphocyte count ( 32888494) Night sleep phenotypes ( 27126917) Periodontal disease-related phenotype (Socransky) ( 24347629)	Post bronchodilator FEV1/FVC ratio ( 26634245) Post-bronchodilator lung function in asthma (FVC) ( 32989782)
Interacting Genes		2 interacting genes: HYOU1 RPL6	15 interacting genes: CADM1 CDC42 CEBPA DPYSL3 IL1R1 IL1RL1 INPPL1 LINC01554 NXPE4 PPP2R1B RBM7 SEL1L TAGLN TMEM245 TP53BP2
Entrez ID		6400	10525
HPRD ID		07532	03448
Ensembl ID		ENSG00000071537	ENSG00000149428
Uniprot IDs		Q3ZCU6 Q9UBV2	A0A384P5T6 A0A494C039 A0A8Q3SHG4 B3KXH0 B7Z602 B7Z766 Q6IN67 Q9Y4L1
PDB IDs		8KES 8KET 8KEV
Enriched GO Terms of Interacting Partners?		Focal Adhesion Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Large Ribosomal Subunit Adenyl-nucleotide Exchange Factor Activity Negative Regulation Of Cellular Response To Hypoxia Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Chaperone Complex Endocytic Vesicle Lumen Smooth Endoplasmic Reticulum Regulation Of Cellular Response To Hypoxia Rough Endoplasmic Reticulum Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway ATP-dependent Protein Folding Chaperone Negative Regulation Of Response To Endoplasmic Reticulum Stress Cytosolic Large Ribosomal Subunit Response To Ischemia Endoplasmic Reticulum	Macrophage Differentiation Interleukin-1 Receptor Activity NAD+ Nucleosidase Activity, Cyclic ADP-ribose Generating SH3 Domain Binding Positive Regulation Of Filopodium Assembly Myeloid Leukocyte Differentiation Positive Regulation Of Macrophage Activation
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