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SEL1L

Description SEL1L adaptor subunit of ERAD E3 ubiquitin ligase
Image No pdb structure
GO Annotations Cellular Component
  • Hrd1p Ubiquitin Ligase Complex
  • Hrd1p Ubiquitin Ligase ERAD-L Complex
  • Endoplasmic Reticulum
  • Endoplasmic Reticulum Membrane
  • Integral Component Of Membrane
  • Derlin-1 Retrotranslocation Complex
  • Endoplasmic Reticulum Quality Control Compartment
Molecular Function
  • Ubiquitin-protein Transferase Activity
  • Protein Binding
Biological Process
  • Triglyceride Metabolic Process
  • Notch Signaling Pathway
  • Protein Secretion
  • Protein Ubiquitination
  • Ubiquitin-dependent ERAD Pathway
  • Retrograde Protein Transport, ER To Cytosol
  • ERAD Pathway
  • Protein Stabilization
  • Transmembrane Transport
  • Endoplasmic Reticulum Mannose Trimming
Pathways
  • Pre-NOTCH Processing in Golgi
  • ABC-family proteins mediated transport
  • Hedgehog ligand biogenesis
  • Hh mutants are degraded by ERAD
  • Defective CFTR causes cystic fibrosis
  • ER Quality Control Compartment (ERQC)
Drugs
Diseases
GWAS
  • Body size at age 10 ( 32376654)
  • Cadmium levels ( 26025379)
  • Intraocular pressure ( 29617998)
  • Lymphocyte counts ( 32888494)
  • Monocyte count ( 32888494)
  • Night sleep phenotypes ( 27126917)
  • Periodontal disease-related phenotype (Socransky) ( 24347629)
Interacting Genes 2 interacting genes: HYOU1 RPL6
Entrez ID 6400
HPRD ID 07532
Ensembl ID ENSG00000071537
Uniprot IDs Q3ZCU6 Q9UBV2
PDB IDs
Enriched GO Terms of Interacting Partners?
Tagcloud ?

© Madhavi K. Ganapathiraju 2012-2025