CHTF18 and RFC5

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)

		CHTF18	RFC5
Description		chromosome transmission fidelity factor 18	replication factor C subunit 5
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Membrane Ctf18 RFC-like Complex	Nucleus Nucleoplasm DNA Replication Factor C Complex Chromosome Ctf18 RFC-like Complex
	Molecular Function	Nucleotide Binding DNA Binding DNA Clamp Loader Activity Protein Binding ATP Binding ATP Hydrolysis Activity Single-stranded DNA Helicase Activity	Nucleotide Binding DNA Binding DNA Clamp Loader Activity Protein Binding ATP Binding ATP Hydrolysis Activity Single-stranded DNA Helicase Activity Enzyme Binding
	Biological Process	DNA Replication Positive Regulation Of DNA-directed DNA Polymerase Activity	DNA Replication DNA-templated DNA Replication DNA Repair Positive Regulation Of DNA-directed DNA Polymerase Activity
Pathways		Polymerase switching on the C-strand of the telomere	Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Polymerase switching on the C-strand of the telomere Activation of ATR in response to replication stress PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Regulation of TP53 Activity through Phosphorylation Polymerase switching G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51
Drugs
Diseases
GWAS		Body mass index ( 26426971) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)	Chronic rhinosinusitis ( 33393196) Metabolite levels ( 23823483) Neurociticism ( 29500382) Obesity-related traits ( 23251661) Physiological traits ( 31902109)
Interacting Genes		5 interacting genes: CRK PCNA RFC4 RFC5 STAT3	37 interacting genes: ARID5A BIRC2 CCNC CEBPA CHTF18 CIMIP2B COPS6 DAPK1 DDIT4L DYNLL1 EEF1A1 EML2 EXOSC8 KRT34 LMO3 LRIF1 MED31 N4BP3 NAB2 NR5A1 PCNA PPP1R16B PTEN RBM48 RFC2 RFC4 SUMO2 TASOR2 TRIM38 TSNAX UNC119 XAF1 XIAP YPEL3 ZMAT1 ZNF19 ZNF426
Entrez ID		63922	5985
HPRD ID		13059	02677
Ensembl ID		ENSG00000127586	ENSG00000111445
Uniprot IDs		Q8WVB6	P40937 Q59GW7
PDB IDs		8UMT 8UMU 8UMV 8UMW 8UMY 8UN0 8UNJ	6VVO 7Z6H 8UI7 8UI8 8UI9 8UII 8UMT 8UMU 8UMV 8UMW 8UMY 8UN0 8UNJ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of DNA-directed DNA Polymerase Activity Positive Regulation Of DNA Biosynthetic Process DNA Replication Factor C Complex Enzyme Binding Regulation Of DNA Biosynthetic Process Ctf18 RFC-like Complex DNA Clamp Loader Activity Regulation Of Catalytic Activity DNA Strand Elongation Involved In DNA Replication DNA Replication Single-stranded DNA Helicase Activity DNA Strand Elongation Positive Regulation Of DNA Metabolic Process Positive Regulation Of Catalytic Activity DNA-templated DNA Replication Receptor Tyrosine Kinase Binding Response To Stress Signaling Adaptor Activity Regulation Of DNA Metabolic Process DNA Repair PCNA Complex Replisome Response To Hydrogen Peroxide Response To Estradiol Response To Hormone Regulation Of Nucleobase-containing Compound Metabolic Process Helper T Cell Diapedesis Protein Phosphorylated Amino Acid Binding Response To Cholecystokinin PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Cerebellar Neuron Development Response To Reactive Oxygen Species DNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Nucleic Acid Metabolic Process Elg1 RFC-like Complex Negative Regulation Of Primary MiRNA Processing Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Skeletal Muscle Cell Proliferation DNA Damage Response Regulation Of Response To Wounding DNA Binding Positive Regulation Of Deoxyribonuclease Activity Leading Strand Elongation RNA Sequestering Activity	Positive Regulation Of DNA-directed DNA Polymerase Activity Regulation Of Macromolecule Metabolic Process Ctf18 RFC-like Complex Regulation Of Metabolic Process DNA Clamp Loader Activity Nucleus Positive Regulation Of DNA Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Single-stranded DNA Helicase Activity Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA Biosynthetic Process Nucleoplasm DNA Replication Factor C Complex Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Enzyme Binding DNA Replication DNA Strand Elongation Involved In DNA Replication Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Polyubiquitination DNA Strand Elongation Identical Protein Binding Protein-containing Complex Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process
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