CHTF18

Description		chromosome transmission fidelity factor 18
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Membrane Ctf18 RFC-like Complex
	Molecular Function	Nucleotide Binding DNA Binding DNA Clamp Loader Activity Protein Binding ATP Binding ATP Hydrolysis Activity Single-stranded DNA Helicase Activity
	Biological Process	DNA Replication Positive Regulation Of DNA-directed DNA Polymerase Activity
Pathways		Polymerase switching on the C-strand of the telomere
Drugs
Diseases
GWAS		Body mass index ( 26426971) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Novel Interacting Genes		5 novel interacting genes: CRK PCNA RFC4 RFC5 STAT3
Interacting Genes		5 interacting genes: CRK PCNA RFC4 RFC5 STAT3
Entrez ID		63922
HPRD ID		13059
Ensembl ID		ENSG00000127586
Uniprot IDs		Q8WVB6
PDB IDs		8UMT 8UMU 8UMV 8UMW 8UMY 8UN0 8UNJ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of DNA-directed DNA Polymerase Activity Positive Regulation Of DNA Biosynthetic Process DNA Replication Factor C Complex Enzyme Binding Regulation Of DNA Biosynthetic Process Ctf18 RFC-like Complex DNA Clamp Loader Activity Regulation Of Catalytic Activity DNA Strand Elongation Involved In DNA Replication DNA Replication Single-stranded DNA Helicase Activity DNA Strand Elongation Positive Regulation Of DNA Metabolic Process Positive Regulation Of Catalytic Activity DNA-templated DNA Replication Receptor Tyrosine Kinase Binding Response To Stress Signaling Adaptor Activity Regulation Of DNA Metabolic Process DNA Repair PCNA Complex Replisome Response To Hydrogen Peroxide Response To Estradiol Response To Hormone Regulation Of Nucleobase-containing Compound Metabolic Process Helper T Cell Diapedesis Protein Phosphorylated Amino Acid Binding Response To Cholecystokinin PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Cerebellar Neuron Development Response To Reactive Oxygen Species DNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Nucleic Acid Metabolic Process Elg1 RFC-like Complex Negative Regulation Of Primary MiRNA Processing Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Skeletal Muscle Cell Proliferation DNA Damage Response Regulation Of Response To Wounding DNA Binding Positive Regulation Of Deoxyribonuclease Activity Leading Strand Elongation RNA Sequestering Activity
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