CCL15 and CCR3

Number of citations of the paper that reports this interaction (PubMedID 9346309)
0

Data Source:
HPRD (in vivo)

		CCL15	CCR3
Description		C-C motif chemokine ligand 15	C-C motif chemokine receptor 3
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytoplasm Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Signaling Receptor Binding Cytokine Activity Chemokine Activity Heparin Binding Chemoattractant Activity CCR Chemokine Receptor Binding	G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	Intracellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Migration Positive Regulation Of Inflammatory Response Positive Chemotaxis Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway	Positive Regulation Of Endothelial Cell Proliferation Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Positive Regulation Of Angiogenesis Cell Chemotaxis Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus
Pathways			Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases
GWAS		Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Upper eyelid sagging severity ( 24869959)	Arthritis (juvenile idiopathic) ( 33106285) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Behcet's disease ( 33393726 23291587) Bone mineral density (Ward's triangle area) ( 27397699) Celiac disease ( 25920553 20190752 22057235 24999842 18311140) Celiac disease and Rheumatoid arthritis ( 26546613) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 26192919) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Monocyte chemoattractant protein-1 levels ( 23017229) Monocyte count ( 27863252 29403010) Narcolepsy with cataplexy ( 25986216) Obesity-related traits ( 23251661) Pancreatic beta-cell glucose sensitivity ( 32944759) Ulcerative colitis ( 26192919 28067908) White blood cell count (basophil) ( 27863252)
Interacting Genes		4 interacting genes: CCL2 CCR1 CCR3 SDF2	19 interacting genes: CCL11 CCL13 CCL14 CCL15 CCL2 CCL24 CCL26 CCL28 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCL8 CXCL10 CXCL11 CXCL9 FGR HCK
Entrez ID		6359	1232
HPRD ID		03232	03167
Ensembl ID		ENSG00000275718	ENSG00000183625
Uniprot IDs		Q16663	P51677 Q8TDP4 Q8TDP5
PDB IDs		2HCC 7VL9 7VLA	7X9Y
Enriched GO Terms of Interacting Partners?		Chemokine-mediated Signaling Pathway Chemokine Receptor Activity Cell Chemotaxis Monocyte Chemotaxis C-C Chemokine Binding C-C Chemokine Receptor Activity Chemotaxis Locomotion Cytokine-mediated Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cellular Response To Cytokine Stimulus Inflammatory Response Response To Cytokine Response To Peptide Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Calcium Ion Transport Mononuclear Cell Migration Helper T Cell Extravasation Chemokine (C-C Motif) Ligand 2 Signaling Pathway Leukocyte Chemotaxis Regulation Of Mononuclear Cell Migration Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Leukocyte Migration G Protein-coupled Receptor Signaling Pathway Myeloid Leukocyte Migration Chemokine (C-C Motif) Ligand 5 Binding Positive Regulation Of Chemotaxis Chemokine (C-C Motif) Ligand 7 Binding Regulation Of Endothelial Cell Proliferation Negative Regulation Of Natural Killer Cell Chemotaxis Cell Adhesion Cell Migration Calcium-mediated Signaling Positive Regulation Of Monoatomic Ion Transport Negative Regulation Of Lymphocyte Chemotaxis Regulation Of Chemotaxis Cell Motility CCR2 Chemokine Receptor Binding Regulation Of Leukocyte Migration Regulation Of Calcium Ion Transport Leukocyte Migration T Cell Extravasation Immune Response Astrocyte Cell Migration Defense Response Positive Regulation Of Apoptotic Cell Clearance Regulation Of Metal Ion Transport External Side Of Plasma Membrane Positive Regulation Of Glutamate Receptor Signaling Pathway	Chemokine Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway CCR Chemokine Receptor Binding Antimicrobial Humoral Response Cell Chemotaxis Cytokine Activity Humoral Immune Response Chemotaxis Granulocyte Chemotaxis Locomotion Defense Response To Symbiont Inflammatory Response Defense Response To Other Organism Granulocyte Migration Eosinophil Chemotaxis Cytokine-mediated Signaling Pathway Leukocyte Chemotaxis Eosinophil Migration Leukocyte Migration Myeloid Leukocyte Migration Response To Other Organism Immune Response Cell Migration Response To External Biotic Stimulus Defense Response Cell Motility Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Locomotion Immune System Process Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Extracellular Space Cell Surface Receptor Signaling Pathway Extracellular Region Response To Stress Regulation Of Lymphocyte Chemotaxis Cell-cell Signaling Signaling Cell Communication Regulation Of Leukocyte Migration Regulation Of Cell Shape Positive Regulation Of Leukocyte Migration Signal Transduction Positive Regulation Of Natural Killer Cell Chemotaxis Positive Regulation Of Calcium Ion Transport Intracellular Calcium Ion Homeostasis
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