HPSE2 and TLL2

		HPSE2	TLL2
Description		heparanase 2 (inactive)	tolloid like 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Extracellular Matrix	Extracellular Region Extracellular Space
	Molecular Function	Hydrolase Activity, Acting On Glycosyl Bonds Heparanase Activity Heparan Sulfate Proteoglycan Binding	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Calcium Ion Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Extracellular Matrix Organization	Proteolysis Dorsal/ventral Pattern Formation Protein Processing Cell Differentiation Collagen Fibril Organization Negative Regulation Of Skeletal Muscle Tissue Growth
Pathways		HS-GAG degradation	Degradation of the extracellular matrix Collagen biosynthesis and modifying enzymes Anchoring fibril formation Crosslinking of collagen fibrils
Drugs			Methyl N-{[(1R)-1-({1-[(benzyloxy)carbonyl]-L-prolyl-6-ammonio-L-norleucyl}amino)-2-phenylethyl](hydroxy)phosphoryl}-L-alanyl-L-prolinate
Diseases		Urofacial syndrome
GWAS		Aspartate aminotransferase levels ( 33547301) Asthma (childhood onset) ( 23829686) Migraine ( 27322543) Obesity-related traits ( 23251661) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy) ( 24554482)	Attention deficit hyperactivity disorder ( 18839057) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Platelet reactivity in response to clopidogrel treatment ( 32472697) Stress sensitivity (neuroticism score x major depressive disorder status interaction) ( 30571770)
Interacting Genes		1 interacting genes: TLL2	5 interacting genes: DNTT HPSE2 PAPSS2 PPP1R3C RBP4
Entrez ID		60495	7093
HPRD ID		13669	05993
Ensembl ID		ENSG00000172987	ENSG00000095587
Uniprot IDs		Q2M1H9 Q8WWQ2	Q9Y6L7
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Skeletal Muscle Tissue Growth Regulation Of Skeletal Muscle Tissue Growth Negative Regulation Of Developmental Growth Dorsal/ventral Pattern Formation Collagen Fibril Organization Metalloendopeptidase Activity Serine-type Endopeptidase Activity Metallopeptidase Activity Extracellular Structure Organization Negative Regulation Of Growth Protein Processing Extracellular Matrix Organization Regionalization	Nucleotidyltransferase Activity DNA Nucleotidylexotransferase Activity Carbohydrate Biosynthetic Process Vitamin A Import Into Cell 3'-phosphoadenosine 5'-phosphosulfate Biosynthetic Process Sulfate Assimilation Sulfate Adenylyltransferase (ATP) Activity Adenylylsulfate Kinase Activity Heparanase Activity Retinol Transmembrane Transporter Activity Female Genitalia Morphogenesis Retinol Transport Hormone Metabolic Process Terpenoid Transport Urinary Bladder Development Embryonic Retina Morphogenesis In Camera-type Eye Glycogen Binding Retinoid Binding Retinal Binding Vagina Development DNA Polymerase Activity Carbohydrate Metabolic Process Protein Phosphatase Type 1 Complex Glycogen Biosynthetic Process Molecular Carrier Activity Genitalia Morphogenesis Heart Trabecula Formation Retinol Binding Lipid Import Into Cell Retinal Metabolic Process Negative Regulation Of Cardiac Muscle Cell Proliferation Female Genitalia Development Vitamin Transmembrane Transport Phototransduction, Visible Light 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Heparan Sulfate Proteoglycan Binding Detection Of Light Stimulus Involved In Visual Perception DNA-directed DNA Polymerase Activity Uterus Development Protein Phosphatase 1 Binding Polysaccharide Biosynthetic Process Detection Of Visible Light Maintenance Of Gastrointestinal Epithelium Negative Regulation Of Cardiac Muscle Tissue Growth DNA Modification Regulation Of Glycogen Biosynthetic Process Response To Muscle Activity Response To ATP Regulation Of Hormone Levels Negative Regulation Of Organ Growth
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