TLL2 and DNTT

		TLL2	DNTT
Description		tolloid like 2	DNA nucleotidylexotransferase
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Chromatin Euchromatin Nucleus Nucleoplasm Cytosol Nuclear Matrix
	Molecular Function	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Calcium Ion Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding	DNA Binding DNA-directed DNA Polymerase Activity DNA Nucleotidylexotransferase Activity Protein Binding Transferase Activity Nucleotidyltransferase Activity DNA Polymerase Activity Metal Ion Binding
	Biological Process	Proteolysis Dorsal/ventral Pattern Formation Protein Processing Cell Differentiation Collagen Fibril Organization Negative Regulation Of Skeletal Muscle Tissue Growth	DNA Metabolic Process DNA Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Modification Response To ATP DNA Biosynthetic Process
Pathways		Degradation of the extracellular matrix Collagen biosynthesis and modifying enzymes Anchoring fibril formation Crosslinking of collagen fibrils
Drugs		Methyl N-{[(1R)-1-({1-[(benzyloxy)carbonyl]-L-prolyl-6-ammonio-L-norleucyl}amino)-2-phenylethyl](hydroxy)phosphoryl}-L-alanyl-L-prolinate	2',3'-Dideoxyadenosine triphosphate
Diseases
GWAS		Attention deficit hyperactivity disorder ( 18839057) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Platelet reactivity in response to clopidogrel treatment ( 32472697) Stress sensitivity (neuroticism score x major depressive disorder status interaction) ( 30571770)
Interacting Genes		5 interacting genes: DNTT HPSE2 PAPSS2 PPP1R3C RBP4	10 interacting genes: ABTB2 DNTTIP1 DNTTIP2 MEI4 PCNA PRPF19 REL TCF4 TLL2 XRCC6
Entrez ID		7093	1791
HPRD ID		05993	08925
Ensembl ID		ENSG00000095587	ENSG00000107447
Uniprot IDs		Q9Y6L7	P04053
PDB IDs			2COE 5W4E
Enriched GO Terms of Interacting Partners?		Nucleotidyltransferase Activity DNA Nucleotidylexotransferase Activity Carbohydrate Biosynthetic Process Vitamin A Import Into Cell 3'-phosphoadenosine 5'-phosphosulfate Biosynthetic Process Sulfate Assimilation Sulfate Adenylyltransferase (ATP) Activity Adenylylsulfate Kinase Activity Heparanase Activity Retinol Transmembrane Transporter Activity Female Genitalia Morphogenesis Retinol Transport Hormone Metabolic Process Terpenoid Transport Urinary Bladder Development Embryonic Retina Morphogenesis In Camera-type Eye Glycogen Binding Retinoid Binding Retinal Binding Vagina Development DNA Polymerase Activity Carbohydrate Metabolic Process Protein Phosphatase Type 1 Complex Glycogen Biosynthetic Process Molecular Carrier Activity Genitalia Morphogenesis Heart Trabecula Formation Retinol Binding Lipid Import Into Cell Retinal Metabolic Process Negative Regulation Of Cardiac Muscle Cell Proliferation Female Genitalia Development Vitamin Transmembrane Transport Phototransduction, Visible Light 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Heparan Sulfate Proteoglycan Binding Detection Of Light Stimulus Involved In Visual Perception DNA-directed DNA Polymerase Activity Uterus Development Protein Phosphatase 1 Binding Polysaccharide Biosynthetic Process Detection Of Visible Light Maintenance Of Gastrointestinal Epithelium Negative Regulation Of Cardiac Muscle Tissue Growth DNA Modification Regulation Of Glycogen Biosynthetic Process Response To Muscle Activity Response To ATP Regulation Of Hormone Levels Negative Regulation Of Organ Growth	Damaged DNA Binding DNA End Binding DNA Metabolic Process Telomere Maintenance Chromosome Organization Double-strand Break Repair Via Nonhomologous End Joining Ku70:Ku80 Complex Chromosome PCNA Complex PCNA-p21 Complex Replisome DNA Polymerase Processivity Factor Activity Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Beta-catenin-TCF7L2 Complex Negative Regulation Of Skeletal Muscle Tissue Growth
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