H2BC26

Description		H2B clustered histone 26
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GO Annotations	Cellular Component	Nucleosome Nucleus Nucleoplasm Chromosome Cytosol
	Molecular Function	DNA Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity
	Biological Process
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) Replacement of protamines by nucleosomes in the male pronucleus MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS
Novel Interacting Genes		5 novel interacting genes: BRD2 CBX5 CDKN2A RPS6KA5 USP7
Interacting Genes		5 interacting genes: BRD2 CBX5 CDKN2A RPS6KA5 USP7
Entrez ID		128312
HPRD ID		13661
Ensembl ID		ENSG00000196890
Uniprot IDs		Q8N257
PDB IDs		6BIZ
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Chromatin Organization P53 Binding Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Ligase Inhibitor Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process TOR Signaling TORC1 Signaling Histone H2AS1 Kinase Activity Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator Histone H4K5ac Reader Activity Histone H4K12ac Reader Activity Chromosome Acetylation-dependent Protein Binding PML Body Histone H3S28 Kinase Activity Nucleoplasm Negative Regulation Of Proteolysis Positive Regulation Of Macrophage Apoptotic Process Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Post-translational Protein Modification Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Senescence-associated Heterochromatin Focus Protein-containing Complex Regulation Of T Cell Differentiation Apoptotic Process Involved In Mammary Gland Involution Histone H3K14ac Reader Activity Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Gene Expression, Epigenetic Symbiont-mediated Disruption Of Host Cell PML Body Histone H3S10 Kinase Activity Negative Regulation Of Protein Neddylation Ubiquitin-protein Transferase Inhibitor Activity Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Negative Regulation Of Biosynthetic Process Negative Regulation Of Immature T Cell Proliferation In Thymus Regulation Of Gene Expression Protein-macromolecule Adaptor Activity Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Mitochondrial Depolarization Oncogene-induced Cell Senescence Negative Regulation Of Immature T Cell Proliferation Positive Regulation Of Apoptotic Process Involved In Morphogenesis Protein Stabilization
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